Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET03YLI)
Name
Breast cancer MCF7 cells (MCF7)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Human breast carcinoma MCF7 cells; MCF 7; MCF.7; MCF-7; Michigan Cancer Foundation-7; ssMCF-7; ssMCF7; MCF7/WT; MCF7-CTRL; IBMF-7
Family Cell line (CELL)  >>  Breast cell line (BREcel)
Organism
Homo sapiens (Human)
Cellosaurus ID CVCL_0031 (click to find more cell line data of this DBT)
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Calcium ascorbate anhydrous Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antioxidant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL196 ) [1]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0031
          DIG Name: Ethyl vanillin Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Flavoring agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 15.69 ug.mL-1 (estimated based on the structural similarity with CHEMBL13883 ) [2]
                   Structural Similarity Tanimoto coefficient = 0.975806452
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0031
          DIG Name: Sodium stearyl fumarate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
lubricant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 60 ug.mL-1 (estimated based on the structural similarity with CHEMBL3126829 ) [3]
                   Structural Similarity Tanimoto coefficient = 0.75
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0031
          DIG Name: Tocopheryl acetate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antioxidant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 500000 nM (tested by experiment) [4]
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0031
          DIG Name: Benzododecinium bromide Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 1000 nM (estimated based on the structural similarity with CHEMBL2414246 ) [5]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0031
          DIG Name: Trehalose Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Complexing agent; Diluent; Flavoring agent; Humectant; Lyophilization aid; Viscosity-controlling agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity EC50 = 97560 nM (estimated based on the structural similarity with CHEMBL4539030 ) [6]
                   Structural Similarity Tanimoto coefficient = 0.94
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0031
          DIG Name: Triethanolamine lauryl sulfate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Complexing agent; Emulsifying agent; Surfactant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 43340 nM (estimated based on the structural similarity with CHEMBL3408657 ) [7]
                   Structural Similarity Tanimoto coefficient = 0.754716981
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0031
References
1 Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives. Eur J Med Chem. 2019 Dec 15; 184:111739.
2 Influenza A (H(1)N(1)) Antiviral and Cytotoxic Agents from Ferula assa-foetida. J Nat Prod. 2009 Sep; 72(9):1568-72.
3 Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents. Eur J Med Chem. 2014 Apr 9; 76:291-300.
4 Design and synthesis of analogs of vitamin E: antiproliferative activity against human breast adenocarcinoma cells. Bioorg Med Chem Lett. 1998 Sep 22; 8(18):2433-8.
5 Synthesis, self-aggregation and biological properties of alkylphosphocholine and alkylphosphohomocholine derivatives of cetyltrimethylammonium bromide, cetylpyridinium bromide, benzalkonium bromide (C16) and benzethonium chloride. Eur J Med Chem. 2013 Aug; 66:46-55.
6 Novel natural compounds from endophytic fungi with anticancer activity. Eur J Med Chem. 2018 Aug 5; 156:316-343.
7 Synthesis of structural analogues of hexadecylphosphocholine and their antineoplastic, antimicrobial and amoebicidal activity. Eur J Med Chem. 2015 Mar 26; 93:263-73.

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