Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0RS6F)
DIG Name	Sodium stearyl fumarate
Synonyms	Click to Show/Hide the Synonyms of This DIG Sodium stearyl fumarate; Pruv; SODIUM OCTADECYL FUMARATE; 4070-80-8; UNII-7CV7WJK4UI; 7CV7WJK4UI; Sodium stearyl fumarate [NF]; sodium;(E)-4-octadecoxy-4-oxobut-2-enoate; Sodium stearyl fumarate (NF); Sodium monostearyl fumarate; Sodium monooctadecyl fumarate; EINECS 223-781-1; Sodium monooctadecyl 2-butenedioate, (E)-; stearyl fumarate sodium; SCHEMBL25393; SCHEMBL25396; CHEMBL2107515; 2-Butenedioic acid (E)-, monoactadecyl ester, sodium salt; DTXSID901021880; AKOS015899539; Fumaric Acid Stearyl Ester Sodium Salt; Fumaric Acid Octadecyl Ester Sodium Salt; S0879; D05876; Fumaric acid, monooctadecyl ester, sodium salt; Q27268090
DIG Function	lubricant
PubChem CID	23665634
Formula	C22H39NaO4
Canonical SMILES	CCCCCCCCCCCCCCCCCCOC(=O)/C=C/C(=O)[O-].[Na+]
InChI	1S/C22H40O4.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-26-22(25)19-18-21(23)24;/h18-19H,2-17,20H2,1H3,(H,23,24);/q;+1/p-1/b19-18+;
InChIKey	STFSJTPVIIDAQX-LTRPLHCISA-M
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=23665634"></iframe>
Structure	3D MOL is not available		2D MOL
Physicochemical Properties	Molecular Weight	390.5	Topological Polar Surface Area	66.4
	XlogP	N.A.	Complexity	369
	Heavy Atom Count	27	Rotatable Bond Count	20
	Hydrogen Bond Donor Count	0	Hydrogen Bond Acceptor Count	4

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Minocycline	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[1]
Valacyclovir	API Info	Herpes zoster [ICD-11: 1E91]		[2]
Oseltamivir	API Info	Influenza virus infection [ICD-11: 1E30]		[3]
Famciclovir	API Info	Genital herpes [ICD-11: 1A94]		[4]
Linezolid	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[5]
Raltegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[6]
Entecavir	API Info	Viral hepatitis [ICD-11: 1E51]		[7]
Nevirapine	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[8]
Ritonavir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[9]
Dolutegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[10]
Moxifloxacin	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[11]
Telaprevir	API Info	Viral hepatitis [ICD-11: 1E51]		[12]
Bedaquiline	API Info	Pulmonary tuberculosis [ICD-11: 1B10]		[13]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Nicotinic acid	API Info	Lung cancer [ICD-11: 2C25]		[14]
Prednisolone	API Info	Multiple myeloma [ICD-11: 2A83]		[15]
Imatinib	API Info	Leiomyosarcoma [ICD-11: 2B58]		[16]
Abemaciclib	API Info	Breast cancer [ICD-11: 2C60]		[17]
Cyclophosphamide	API Info	Multiple myeloma [ICD-11: 2A83]		[18]
Pomalidomide	API Info	Breast cancer [ICD-11: 2C60]		[19]
Olaparib	API Info	Ovarian cancer [ICD-11: 2C73]		[20]
Venetoclax	API Info	Chronic lymphocytic leukaemia [ICD-11: 2A82]		[21]
Osimertinib	API Info	Lung cancer [ICD-11: 2C25]		[22]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Fenofibrate	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[23]
Atorvastatin	API Info	Hyperlipidaemia [ICD-11: 5C8Z]		[24]
Potassium chloride	API Info	Hypokalemia [ICD-11: 5C77]		[25]
Pravastatin	API Info	Dyslipidaemia [ICD-11: 5C81]		[26]
Glipizide	API Info	Diabetes mellitus [ICD-11: 5A10]		[27]
Rosuvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[28]
Calcium acetate	API Info	Hyperphosphatemia [ICD-11: 5C64]		[29]
Fenofibric acid	API Info	Dyslipidaemia [ICD-11: 5C81]		[30]
Nateglinide	API Info	Diabetes mellitus [ICD-11: 5A10]		[31]
Ezetimibe	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[32]
Sitagliptin	API Info	Diabetes mellitus [ICD-11: 5A10]		[33]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Risperidone	API Info	Schizophrenia [ICD-11: 6A20]		[34]
Bupropion	API Info	Nicotine dependence [ICD-11: 6C4A]		[35]
Lamotrigine	API Info	Bipolar disorder [ICD-11: 6A60]		[36]
Venlafaxine	API Info	Major depressive disorder [ICD-11: 6A70]		[37]
Olanzapine	API Info	Schizophrenia [ICD-11: 6A20]		[38]
Methylphenidate	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[39]
Mirtazapine	API Info	Major depressive disorder [ICD-11: 6A70]		[40]
Fluvoxamine	API Info	Obsessive-compulsive disorder [ICD-11: 6B20]		[41]
Clozapine	API Info	Schizophrenia [ICD-11: 6A20]		[42]
Buprenorphine	API Info	Opiate dependence [ICD-11: 6C43]		[43]
Paliperidone	API Info	Bipolar disorder [ICD-11: 6A60]		[44]
Lorazepam	API Info	Anxiety disorder [ICD-11: 6B00]		[45]
ICD Disease Classification 07		Sleep-wake disorder	Click to Show/Hide
Zolpidem	API Info	Insomnia [ICD-11: 7A00]		[46]
Modafinil	API Info	Narcolepsy [ICD-11: 7A20]		[47]
Armodafinil	API Info	Obstructive sleep apnoea [ICD-11: 7A41]		[48]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Pramipexole	API Info	Parkinsonism [ICD-11: 8A00]		[49]
Tramadol	API Info	Anaesthesia [ICD-11: 8E22]		[50]
Clonazepam	API Info	Epilepsy [ICD-11: 8A60]		[51]
Oxymorphone	API Info	Anaesthesia [ICD-11: 8E22]		[52]
Galantamine	API Info	Alzheimer disease [ICD-11: 8A20]		[53]
Oxcarbazepine	API Info	Epilepsy [ICD-11: 8A60]		[54]
Memantine	API Info	Alzheimer disease [ICD-11: 8A20]		[55]
Rizatriptan	API Info	Migraine [ICD-11: 8A80]		[56]
Donepezil	API Info	Alzheimer disease [ICD-11: 8A20]		[57]
Zolmitriptan	API Info	Migraine [ICD-11: 8A80]		[58]
Almotriptan	API Info	Migraine [ICD-11: 8A80]		[59]
Tetrabenazine	API Info	Huntington disease [ICD-11: 8A01]		[60]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Aspirin	API Info	Myocardial infarction [ICD-11: BA41]		[61]
Metoprolol	API Info	Essential hypertension [ICD-11: BA00]		[62]
Ramipril	API Info	Essential hypertension [ICD-11: BA00]		[63]
Felodipine	API Info	Essential hypertension [ICD-11: BA00]		[64]
Telmisartan	API Info	Essential hypertension [ICD-11: BA00]		[65]
Trandolapril	API Info	Essential hypertension [ICD-11: BA00]		[66]
Irbesartan	API Info	Essential hypertension [ICD-11: BA00]		[67]
Fosinopril	API Info	Essential hypertension [ICD-11: BA00]		[68]
Flecainide	API Info	Ventricular tachyarrhythmia [ICD-11: BC71]		[69]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Montelukast	API Info	Asthma [ICD-11: CA23]		[70]
Clarithromycin	API Info	Pneumocystis pneumonia [ICD-11: CA40]		[71]
Loratadine	API Info	Allergic rhinitis [ICD-11: CA08]		[72]
Desloratadine	API Info	Allergic rhinitis [ICD-11: CA08]		[73]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Omeprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[74]
Pantoprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[75]
Meclizine	API Info	Functional nausea/vomiting [ICD-11: DD90]		[76]
Lansoprazole	API Info	Duodenal ulcer [ICD-11: DA63]		[77]
Esomeprazole	API Info	Duodenal ulcer [ICD-11: DA63]		[78]
Ondansetron	API Info	Gastritis [ICD-11: DA42]		[79]
Rabeprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[80]
Aprepitant	API Info	Functional nausea/vomiting [ICD-11: DD90]		[81]
ICD Disease Classification 14		Skin disease	Click to Show/Hide
Demeclocycline	API Info	Acne vulgaris [ICD-11: ED80]		[82]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Indomethacin	API Info	Rheumatoid arthritis [ICD-11: FA20]		[83]
Celecoxib	API Info	Rheumatoid arthritis [ICD-11: FA20]		[84]
Diclofenac	API Info	Knee osteoarthritis [ICD-11: FA01]		[85]
Meloxicam	API Info	Rheumatoid arthritis [ICD-11: FA20]		[86]
Risedronic acid	API Info	Paget's disease [ICD-11: FB85]		[87]
Metaxalone	API Info	Myalgia [ICD-11: FB56]		[88]
Diflunisal	API Info	Osteoporosis [ICD-11: FB83]		[89]
Ibandronic acid	API Info	Osteoporosis [ICD-11: FB83]		[90]
Raloxifene	API Info	Osteoporosis [ICD-11: FB83]		[91]
Sulfasalazine	API Info	Rheumatoid arthritis [ICD-11: FA20]		[92]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Tolterodine	API Info	Overactive bladder [ICD-11: GC50]		[93]
Sevelamer	API Info	Chronic kidney disease [ICD-11: GB61]		[94]
ICD Disease Classification 17		Sexual health-related condition	Click to Show/Hide
Sildenafil	API Info	Erectile dysfunction [ICD-11: HA01]		[95]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Cell line (CELL)
DBT Name: Leukemia K562 cells (K562)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 20.2 ug.mL-1 (estimated based on the structural similarity with CHEMBL3126829 )		[96]
Structural Similarity	Tanimoto coefficient = 0.75
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0004
DBT Name: Breast cancer MCF7 cells (MCF7)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 60 ug.mL-1 (estimated based on the structural similarity with CHEMBL3126829 )		[96]
Structural Similarity	Tanimoto coefficient = 0.75
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0031

References
1	FDA label for approved minocycline from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved valacyclovir from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved oseltamivir from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved famciclovir from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved linezolid from the official website of the U.S. Food and Drug Administration.
6	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
7	FDA label for approved entecavir from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved nevirapine from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved ritonavir from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved dolutegravir from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved moxifloxacin from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved telaprevir from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved bedaquiline from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved nicotinic acid from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved prednisolone from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved imatinib from the official website of the U.S. Food and Drug Administration.
17	2017 FDA drug approvals. Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
18	FDA label for approved cyclophosphamide from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved pomalidomide from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved olaparib from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved venetoclax from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved osimertinib from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved fenofibrate from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved atorvastatin from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved potassium chloride from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved pravastatin from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved glipizide from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved rosuvastatin from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved calcium acetate from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved fenofibric acid from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved nateglinide from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved ezetimibe from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved sitagliptin from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved risperidone from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved bupropion from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved lamotrigine from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved venlafaxine from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved olanzapine from the official website of the U.S. Food and Drug Administration.
39	FDA label for approved methylphenidate from the official website of the U.S. Food and Drug Administration.
40	FDA label for approved mirtazapine from the official website of the U.S. Food and Drug Administration.
41	FDA label for approved fluvoxamine from the official website of the U.S. Food and Drug Administration.
42	FDA label for approved clozapine from the official website of the U.S. Food and Drug Administration.
43	FDA label for approved buprenorphine from the official website of the U.S. Food and Drug Administration.
44	FDA label for approved paliperidone from the official website of the U.S. Food and Drug Administration.
45	FDA label for approved lorazepam from the official website of the U.S. Food and Drug Administration.
46	FDA label for approved zolpidem from the official website of the U.S. Food and Drug Administration.
47	FDA label for approved modafinil from the official website of the U.S. Food and Drug Administration.
48	FDA label for approved armodafinil from the official website of the U.S. Food and Drug Administration.
49	FDA label for approved pramipexole from the official website of the U.S. Food and Drug Administration.
50	FDA label for approved tramadol from the official website of the U.S. Food and Drug Administration.
51	FDA label for approved clonazepam from the official website of the U.S. Food and Drug Administration.
52	FDA label for approved oxymorphone from the official website of the U.S. Food and Drug Administration.
53	FDA label for approved galantamine from the official website of the U.S. Food and Drug Administration.
54	FDA label for approved oxcarbazepine from the official website of the U.S. Food and Drug Administration.
55	FDA label for approved memantine from the official website of the U.S. Food and Drug Administration.
56	FDA label for approved rizatriptan from the official website of the U.S. Food and Drug Administration.
57	FDA label for approved donepezil from the official website of the U.S. Food and Drug Administration.
58	FDA label for approved zolmitriptan from the official website of the U.S. Food and Drug Administration.
59	FDA label for approved almotriptan from the official website of the U.S. Food and Drug Administration.
60	FDA label for approved tetrabenazine from the official website of the U.S. Food and Drug Administration.
61	FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
62	FDA label for approved metoprolol from the official website of the U.S. Food and Drug Administration.
63	FDA label for approved ramipril from the official website of the U.S. Food and Drug Administration.
64	FDA label for approved felodipine from the official website of the U.S. Food and Drug Administration.
65	FDA label for approved telmisartan from the official website of the U.S. Food and Drug Administration.
66	FDA label for approved trandolapril from the official website of the U.S. Food and Drug Administration.
67	FDA label for approved irbesartan from the official website of the U.S. Food and Drug Administration.
68	FDA label for approved fosinopril from the official website of the U.S. Food and Drug Administration.
69	FDA label for approved flecainide from the official website of the U.S. Food and Drug Administration.
70	FDA label for approved montelukast from the official website of the U.S. Food and Drug Administration.
71	FDA label for approved clarithromycin from the official website of the U.S. Food and Drug Administration.
72	FDA label for approved loratadine from the official website of the U.S. Food and Drug Administration.
73	FDA label for approved desloratadine from the official website of the U.S. Food and Drug Administration.
74	FDA label for approved omeprazole from the official website of the U.S. Food and Drug Administration.
75	FDA label for approved pantoprazole from the official website of the U.S. Food and Drug Administration.
76	FDA label for approved meclizine from the official website of the U.S. Food and Drug Administration.
77	FDA label for approved lansoprazole from the official website of the U.S. Food and Drug Administration.
78	FDA label for approved esomeprazole from the official website of the U.S. Food and Drug Administration.
79	FDA label for approved ondansetron from the official website of the U.S. Food and Drug Administration.
80	FDA label for approved rabeprazole from the official website of the U.S. Food and Drug Administration.
81	FDA label for approved aprepitant from the official website of the U.S. Food and Drug Administration.
82	FDA label for approved demeclocycline from the official website of the U.S. Food and Drug Administration.
83	FDA label for approved indomethacin from the official website of the U.S. Food and Drug Administration.
84	FDA label for approved celecoxib from the official website of the U.S. Food and Drug Administration.
85	FDA label for approved diclofenac from the official website of the U.S. Food and Drug Administration.
86	FDA label for approved meloxicam from the official website of the U.S. Food and Drug Administration.
87	FDA label for approved risedronic acid from the official website of the U.S. Food and Drug Administration.
88	FDA label for approved metaxalone from the official website of the U.S. Food and Drug Administration.
89	FDA label for approved diflunisal from the official website of the U.S. Food and Drug Administration.
90	FDA label for approved ibandronic acid from the official website of the U.S. Food and Drug Administration.
91	FDA label for approved raloxifene from the official website of the U.S. Food and Drug Administration.
92	FDA label for approved sulfasalazine from the official website of the U.S. Food and Drug Administration.
93	FDA label for approved tolterodine from the official website of the U.S. Food and Drug Administration.
94	FDA label for approved sevelamer from the official website of the U.S. Food and Drug Administration.
95	FDA label for approved sildenafil from the official website of the U.S. Food and Drug Administration.
96	Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents. Eur J Med Chem. 2014 Apr 9; 76:291-300.

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