Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET04RMS)
Name
Thrombopoietin receptor (MPL)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; C-mpl; CD110; CD110 antigen; TPO-R; TPOR
Family Other protein families (OPF)  >>  Cytokine receptor (CKR)
Organism
Homo sapiens (Human)
Gene Name MPL Gene ID
4352
UniProt ID TPOR_HUMAN (click to find more protein-related data of this DBT)
TTD ID T16156 (click to find more therapeutic target data of this DBT)
   Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
Function
May represent a regulatory molecule specific for TPO-R-dependent immune responses. Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production.
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Allura red AC dye Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Colorant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity EC50 = 300 nM (estimated based on the structural similarity with CHEMBL123373 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.925714286
                   Tested Species Homo sapiens (Human)
                   UniProt ID TPOR_HUMAN
          DIG Name: Silotermo carmine G Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Colorant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity EC50 = 10000 nM (estimated based on the structural similarity with CHEMBL331220 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.886010363
                   Tested Species Homo sapiens (Human)
                   UniProt ID TPOR_HUMAN
          DIG Name: Sunset yellow FCF Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Colorant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity EC50 = 3000 nM (estimated based on the structural similarity with CHEMBL122867 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.93081761
                   Tested Species Homo sapiens (Human)
                   UniProt ID TPOR_HUMAN
References
1 Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis. J Med Chem. 2001 Oct 25; 44(22):3730-45.

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