Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET05OCC)
Name
Aldehyde dehydrogenase 5A1 (ALDH5A1)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Aldehyde dehydrogenase family 5 member A1; NAD(+)-dependent succinic semialdehyde dehydrogenase; SSADH; Succinate-semialdehyde dehydrogenase, mitochondrial; Succinic dehydrogenase; Succinate-semialdehyde dehydrogenase
Family Oxidoreductase (ORase)  >>  Aldehyde/oxo donor oxidoreductase (EC 1.2)
Organism
Homo sapiens (Human)
Gene Name ALDH5A1 Gene ID
7915
UniProt ID SSDH_HUMAN (click to find more protein-related data of this DBT)
TTD ID T13259 (click to find more therapeutic target data of this DBT)
INTEDE ID DME0214 (click to find more drug-metabolizing enzyme data of this DBT)
   Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR
TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER
SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH
TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL
AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV
KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAF
AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFF
EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWR
VAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
Function
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Ethyl vanillin Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Flavoring agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 15600 nM (estimated based on the structural similarity with CHEMBL13883 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.975806452
                   Tested Species Homo sapiens (Human)
                   UniProt ID SSDH_HUMAN
          DIG Name: Vanillin Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Flavoring agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 15600 nM (tested by experiment) [1]
                   Tested Species Homo sapiens (Human)
                   UniProt ID SSDH_HUMAN
References
1 Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb; 16(3):592-5.

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