Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0JQ5V)
Name
Colon cancer HCT-116 cells (HCT-116)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Human colon carcinoma HCT-116 cells; HCT-116; HCT.116; HCT_116; HCT116; CoCL2
Family Cell line (CELL)  >>  Colon cell line (COLcel)
Organism
Homo sapiens (Human)
Cellosaurus ID CVCL_0291 (click to find more cell line data of this DBT)
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Calcium ascorbate anhydrous Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antioxidant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL196 ) [1]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0291
          DIG Name: Sodium lauryl sulfate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 100000 nM (tested by experiment) [2]
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0291
References
1 Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives. Eur J Med Chem. 2019 Dec 15; 184:111739.
2 Synthesis of amphiphilic, chalcogen-based redox modulators with in vitro cytotoxic activity against cancer cells, macrophages and microbes. Med Chem Comm. (2014) 5:25-31.

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