Details of the Biological Target of DIG (DBT)
| General Information of DBT (ID: ET0KW9V) | |||||
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| Name |
GluA1-GluA2 complex (GRIA1-GRIA2)
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| Synonyms |
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AMPA-selective glutamate receptor 1 complexed with AMPA-selective glutamate receptor 2; GluA1 complexed with GluA2; GluR-1 complexed with GluR-2; GluR-A complexed with GluR-B; GluR-K1 complexed with GluR-K2; Glutamate receptor 1 complexed with Glutamate receptor 2; Glutamate receptor ionotropic, AMPA 1 complexed with Glutamate receptor ionotropic, AMPA 2
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| Family | Transmembrane channel/porin (TC/P) >> Glutamate-gated ion channel (GIC) | ||||
| Organism |
Homo sapiens (Human)
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| UniProt ID | GRIA1_HUMAN | (click to find more protein-related data of this DBT) | |||
| GRIA2_HUMAN | (click to find more protein-related data of this DBT) | ||||
| Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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| DIG Name: Glutamic acid hydrochloride | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Acidulant
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | EC50 = 6160 nM (estimated based on the structural similarity with CHEMBL575060 ) | [1] | ||||
| Structural Similarity | Tanimoto coefficient = 0.979166667 | |||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | GRIA1_HUMAN ; GRIA2_HUMAN | |||||
| References | |||||
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| 1 | Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem. 2010 Feb 15; 18(4):1381-7. | ||||
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