Details of the Biological Target of DIG (DBT)
| General Information of DBT (ID: ET0O5HV) | |||||
|---|---|---|---|---|---|
| Name |
DNA topoisomerase II (TOP2)
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| Family | Lyase/isomerase/ligase (L/I/G) >> Macromolecular isomerase (EC 5.6) | ||||
| Organism |
Homo sapiens (Human)
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| UniProt ID | TOP2A_HUMAN | (click to find more protein-related data of this DBT) | |||
| TOP2B_HUMAN | (click to find more protein-related data of this DBT) | ||||
| TTD ID | T96144 | (click to find more therapeutic target data of this DBT) | |||
| Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
|---|---|---|---|---|---|---|
| DIG Name: Cholesterol | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Emollient; Emulsifying agent
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 > 500000 nM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | TOP2A_HUMAN ; TOP2B_HUMAN | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Molecular design of cholesterols as inhibitors of DNA polymerase alpha. J Med Chem. 2004 Sep 23; 47(20):4971-4. | ||||
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