Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0Y3WE)
Name
Cathepsin L (CTSL)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Major excreted protein; Cathepsin L1; MEP; CTSL1
Family Hydrolase (HDase)  >>  Peptidase (EC 3.4)
Organism
Homo sapiens (Human)
Gene Name CTSL Gene ID
1514
UniProt ID CATL1_HUMAN (click to find more protein-related data of this DBT)
TTD ID T41141 (click to find more therapeutic target data of this DBT)
   Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Function
Important for the overall degradation of proteins in lysosomes.
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Ethyl acetate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Flavoring agent; Solvent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 10000 nM (tested by experiment) [1]
                   Tested Species Homo sapiens (Human)
                   UniProt ID CATL1_HUMAN
References
1 Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L. Bioorg Med Chem. 2015 Nov 1; 23(21):6974-92.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.