Details of the Drug Formulation (DFM)
| General Information of DFM (ID: F07138) | |||||
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| Name |
Duloxetine 60 mg capsule
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| Company |
Unit Dose Services
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| Active Pharmaceutical Ingredient (API) | Duloxetine |
API Info
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| Major depressive disorder | ICD-11: 6A70 | Approved | |||
| Drug Inactive Ingredient (DIGs) | |||||
| DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
| E0A1CS | DIG Info | Ammonia | Alkalizing agent | ||
| E02FBG | DIG Info | Ferrosoferric oxide | Colorant | ||
| E0ND5Z | DIG Info | Potassium hydroxide | Alkalizing agent | ||
| E0M1JK | DIG Info | Propylene glycol | Antimicrobial preservative ... | ||
| E0Q3PU | DIG Info | Saccharose | Binding agent ... | ||
| E0QY1F | DIG Info | Talc | Anticaking agent ... | ||
| E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
| E0K0OU | DIG Info | Triethyl citrate | Plasticizing agent ... | ||
| Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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| Oxidoreductase (ORase) | ||||||
| DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Propylene glycol | |||||
| Biological Activity | Inhibition ratio < 20 % (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88. | ||||
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