Details of the Drug Formulation (DFM)

General Information of DFM (ID: F16153)
Name
Oxcarbazepine 600 mg tablet
Company
Glenmark Pharmaceutials; RemedyRepack
Active Pharmaceutical Ingredient (API) Oxcarbazepine API Info click to show the detail info of this API
Epilepsy ICD-11: 8A60 Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0M0IE DIG Info Ferric hydroxide oxide yellow Colorant
E01UTP DIG Info Magnesium stearate lubricant
E0DS2Q DIG Info Meglumine Buffering agent
E01UTV DIG Info Silicon dioxide Anticaking agent ...
E05BSD DIG Info Titanium dioxide Coating agent ...
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Oxidoreductase (ORase)
            DBT Name: Albendazole monooxygenase (CYP3A4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Magnesium stearate
                    Biological Activity Protein expression downregulation (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Silicon dioxide
                    Biological Activity Protein expression downregulation (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
      Transferase (TFase)
            DBT Name: Alglucerase (GBA) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Meglumine
                    Biological Activity IC50 = 447000 nM (estimated based on the structural similarity with CHEMBL1933095 ) [2]
                    Structural Similarity Tanimoto coefficient = 0.846153846
                    Tested Species Bos taurus (Bovine)
                    UniProt ID GLCM_BOVIN
References
1 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
2 Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes. Bioorg Med Chem. 2012 Jan 15; 20(2):641-9.

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