Details of the Drug Formulation (DFM)
| General Information of DFM (ID: F16473) | |||||
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| Name |
Palonosetron 0.5 mg capsule
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| Company |
Eisai
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| Active Pharmaceutical Ingredient (API) | Palonosetron |
API Info
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| Functional nausea/vomiting | ICD-11: DD90 | Approved | |||
| Drug Inactive Ingredient (DIGs) | |||||
| DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
| E0QV6C | DIG Info | Butylhydroxyanisole | Antimicrobial preservative ... | ||
| E06WYP | DIG Info | Glycerin | Antimicrobial preservative ... | ||
| E0H2SC | DIG Info | Water | Solvent | ||
| Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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| G-protein coupled receptor (GPCR) | ||||||
| DBT Name: Muscarinic receptor M1 (ACM1) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Butylhydroxyanisole | |||||
| Biological Activity | IC50 = 19 uM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | ACM1_HUMAN | |||||
| DBT Name: Alpha-1A adrenoceptor (ADA1A) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Butylhydroxyanisole | |||||
| Biological Activity | IC50 = 19 uM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | ADA1A_HUMAN | |||||
| Oxidoreductase (ORase) | ||||||
| DBT Name: Prostaglandin G/H synthase 2 (COX-2) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Butylhydroxyanisole | |||||
| Biological Activity | IC50 = 2.6 uM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | PGH2_HUMAN | |||||
| Nuclear receptor (NR) | ||||||
| DBT Name: Progesterone receptor (PGR) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
click to show the detail info of this DBT
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Butylhydroxyanisole | |||||
| Biological Activity | IC50 = 29 uM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | PRGR_HUMAN | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413. | ||||
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