General Information of DFM (ID: F17616)
Name
Prasugrel 5 mg tablet
Company
Aurobindo Pharma
Active Pharmaceutical Ingredient (API) Prasugrel API Info click to show the detail info of this API
Myocardial infarction ICD-11: BA41 Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0M0IE DIG Info Ferric hydroxide oxide yellow Colorant
E0EI2M DIG Info Glyceryl dibehenate Binding agent ...
E00DHW DIG Info Lactose monohydrate Binding agent ...
E0Q6DQ DIG Info Mannitol Diluent ...
E0I8GZ DIG Info Sucrose stearate Dispersing agent ...
E05BSD DIG Info Titanium dioxide Coating agent ...
E0T2AJ DIG Info Triacetin Humectant ...
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Oxidoreductase (ORase)
            DBT Name: Cytochrome P450 2E1 (CYP2E1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Sucrose stearate
                    Biological Activity EC50 = 173.9 uM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2E1_HUMAN
      Transmembrane channel/porin (TC/P)
            DBT Name: Glycine receptor alpha-1 (GLRA1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Mannitol
                    Biological Activity EC50 = 12589.25 nM (estimated based on the structural similarity with CHEMBL604608 ) [2]
                    Structural Similarity Tanimoto coefficient = 0.804878049
                    Tested Species Homo sapiens (Human)
                    UniProt ID GLRA1_HUMAN
      Cell line (CELL)
            DBT Name: Lung cancer A-549 cells (A-549) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Sucrose stearate
                    Biological Activity IC50 = 0.63 ug.mL-1 (estimated based on the structural similarity with CHEMBL552345 ) [3]
                    Structural Similarity Tanimoto coefficient = 0.940298507
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0023
References
1 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
2 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
3 Total synthesis and anticancer activity of highly potent novel glycolipid derivatives. Eur J Med Chem. 2009 Aug; 44(8):3120-9.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.