General Information of DFM (ID: F19903)
Name	Sevelamer 800 mg tablet
Company	Amneal Pharmaceuticals
Active Pharmaceutical Ingredient (API)	Sevelamer		API Info click to show the detail info of this API
	Chronic kidney disease		ICD-11: GB61	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0A1CS	DIG Info	Ammonia	Alkalizing agent
	E02FBG	DIG Info	Ferrosoferric oxide	Colorant
	E0M1JK	DIG Info	Propylene glycol	Antimicrobial preservative ...
	E01UTV	DIG Info	Silicon dioxide	Anticaking agent ...
	E0U3AI	DIG Info	Zinc stearate	lubricant

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Propylene glycol
Biological Activity	Inhibition ratio < 20 % (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Silicon dioxide
Biological Activity	Protein expression downregulation (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN

References
1	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
2	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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