General Information of DFM (ID: F21387)
Name	Topiramate 50 mg capsule
Company	Upsher-Smith Laboratories
Active Pharmaceutical Ingredient (API)	Topiramate		API Info click to show the detail info of this API
	Focal seizure		ICD-11: 8A68	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0N6BJ	DIG Info	Diethyl phthalate	Plasticizing agent ...
	E0M0IE	DIG Info	Ferric hydroxide oxide yellow	Colorant
	E02FBG	DIG Info	Ferrosoferric oxide	Colorant
	E05BSD	DIG Info	Titanium dioxide	Coating agent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Hydrolase (HDase)
DBT Name: Phosphodiesterase 4D (PDE4D)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Diethyl phthalate
Biological Activity	IC50 = 8.5 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	PDE4D_HUMAN
Cell line (CELL)
DBT Name: Lung cancer A-549 cells (A-549)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Diethyl phthalate
Biological Activity	IC50 = 38000 nM (estimated based on the structural similarity with CHEMBL4071043 )					[2]
Structural Similarity	Tanimoto coefficient = 0.970588235
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0023

References
1	The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
2	Novel bioactive molecules from Lentzea violacea strain AS 08 using one strain-many compounds (OSMAC) approach. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2579-2582.

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