General Information of DFM (ID: F23146)
Name	Edaravone 30 mg/100 ml Injection
Company	Mitsubishi Tanabe Pharma America
Active Pharmaceutical Ingredient (API)	Edaravone		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0U6KS	DIG Info	Cysteine hydrochloride	Antioxidant
	E0SM9B	DIG Info	Phosphoric acid	Acidulant ...
	E0T4TW	DIG Info	Sodium chloride	Diluent ...
	E0L2PN	DIG Info	Sodium hydroxide	Alkalizing agent
	E09DYC	DIG Info	Sodium sulhydrate	Antimicrobial preservative

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium sulhydrate
Biological Activity	Inhibition ratio < 90 % (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Transferase (TFase)
DBT Name: ABHD5-Perilipin complex (ABHD5-PLIN1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Cysteine hydrochloride
Biological Activity	IC50 = 7335 nM (estimated based on the structural similarity with CHEMBL1426508 )					[2]
Structural Similarity	Tanimoto coefficient = 0.826086957
Tested Species	Homo sapiens (Human)
UniProt ID	ABHD5_HUMAN ; PLIN1_HUMAN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Carbonic anhydrase IV (CA4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Phosphoric acid
Biological Activity	Ki = 9800 nM (estimated based on the structural similarity with CHEMBL1060 )					[3]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
UniProt ID	CAH4_HUMAN

References
1	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
2	PubChem BioAssay data set.
3	Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet. Bioorg Med Chem Lett. 2004 Dec 6; 14(23):5763-7.

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