General Information of DFM (ID: F23260)
Name	Podofilox 0.5% solution
Company	Actavis Pharma
Active Pharmaceutical Ingredient (API)	Podofilox		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0SF4Y	DIG Info	Ethanol	Antimicrobial preservative ...
	E0D6JV	DIG Info	Lactic acid	Acidulant
	E0TB6W	DIG Info	Sodium alpha-hydroxypropionate	Antimicrobial preservative ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Cell line (CELL)
DBT Name: Fetal lung MRC5 cells (MRC5)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Lactic acid
Biological Activity	IC50 = 23930 nM (estimated based on the structural similarity with CHEMBL330546 )					[1]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0440

References
1	Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification. Eur J Med Chem. 2017 Sep 29; 138:644-660.

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