General Information of DFM (ID: F23313)
Name	Trabectedin 1mg/vial powder
Company	Janssen Prods
Active Pharmaceutical Ingredient (API)	Trabectedin		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0SM9B	DIG Info	Phosphoric acid	Acidulant ...
	E0ND5Z	DIG Info	Potassium hydroxide	Alkalizing agent
	E0V4HH	DIG Info	Potassium phosphate monobasic	Buffering agent
	E0Q3PU	DIG Info	Saccharose	Binding agent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Hydrolase (HDase)
DBT Name: Intestinal alkaline phosphatase (IAP)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Potassium phosphate monobasic
Biological Activity	IC50 = 2410 nM (tested by experiment)					[1]
Tested Species	Bos taurus (Bovine)
UniProt ID	PPBI_BOVIN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Carbonic anhydrase IV (CA4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Phosphoric acid
Biological Activity	Ki = 9800 nM (estimated based on the structural similarity with CHEMBL1060 )					[2]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
UniProt ID	CAH4_HUMAN

References
1	Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines. Eur J Med Chem. 2014 May 6; 78:167-77.
2	Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet. Bioorg Med Chem Lett. 2004 Dec 6; 14(23):5763-7.

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