Details of the Drug Formulation (DFM)
General Information of DFM (ID: F23746) | |||||
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Name |
Fluocinolone Acetonide 0.01% oil
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Company |
Seton Pharmaceuticals
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Active Pharmaceutical Ingredient (API) | Fluocinolone acetonide | API Info click to show the detail info of this API | |||
Approved | |||||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E00PSA | DIG Info | Glyceryl monooleate | Bioadhesive material ... | ||
E0N2PK | DIG Info | Isopropyl alcohol | Antimicrobial preservative ... | ||
E07RWU | DIG Info | Isopropyl myristate | Emollient ... | ||
E05WMG | DIG Info | Oleth-2 | Emulsifying agent ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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G-protein coupled receptor (GPCR) | ||||||
DBT Name: Cannabinoid CB1 receptor (CNR1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Oleth-2 | |||||
Biological Activity | EC50 = 39810.72 nM (estimated based on the structural similarity with CHEMBL200113 ) | [1] | ||||
Structural Similarity | Tanimoto coefficient = 0.793103448 | |||||
Tested Species | Rattus norvegicus (Rat) | |||||
UniProt ID | CNR1_RAT | |||||
Transferase (TFase) | ||||||
DBT Name: Diacylglycerol kinase alpha (DGKA) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Glyceryl monooleate | |||||
Biological Activity | Ki = 91000 nM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | DGKA_HUMAN | |||||
Primary active transporter (PAT) | ||||||
DBT Name: Multidrug resistance protein 2 (ABCC2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Glyceryl monooleate | |||||
Biological Activity | Inhibition ratio = 62 % (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MRP2_HUMAN | |||||
DBT Name: Multidrug resistance protein 1 (ABCB1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Glyceryl monooleate | |||||
Biological Activity | Protein expression downregulation = 39.1 % (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Glyceryl monooleate | |||||
Biological Activity | Inhibition ratio = 39 % (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Glyceryl monooleate | |||||
Biological Activity | Inhibition ratio = 63 % (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
Cell line (CELL) | ||||||
DBT Name: Lymphoma P388/ADR cells (P388/ADR) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Isopropyl alcohol | |||||
Biological Activity | IC50 = 0.22 uM (estimated based on the structural similarity with CHEMBL545 ) | [5] | ||||
Structural Similarity | Tanimoto coefficient = 0.789473684 | |||||
Tested Species | Mus musculus (Mouse) | |||||
Cellosaurus ID | CVCL_IZ75 | |||||
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