Details of the Drug Formulation (DFM)
| General Information of DFM (ID: F23955) | |||||
|---|---|---|---|---|---|
| Name |
Daclatasvir Dihydrochloride eq 60mg base tablet
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| Company |
Bristol-Myers Squibb
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| Active Pharmaceutical Ingredient (API) | Daclatasvir |
API Info
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| Viral hepatitis | ICD-11: 1E51 | Approved | |||
| Drug Inactive Ingredient (DIGs) | |||||
| DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
| E0SJ4H | DIG Info | Beta-D-lactose | Diluent ... | ||
| E03SQI | DIG Info | Carmellose sodium | Disintegrant | ||
| E0V2QO | DIG Info | Cellulose microcrystalline | Adsorbent ... | ||
| E01UTP | DIG Info | Magnesium stearate | lubricant | ||
| E01UTV | DIG Info | Silicon dioxide | Anticaking agent ... | ||
| Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
|---|---|---|---|---|---|---|
| Oxidoreductase (ORase) | ||||||
| DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Magnesium stearate | |||||
| Biological Activity | Protein expression downregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Carmellose sodium | |||||
| Biological Activity | Protein expression upregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Carmellose sodium | |||||
| Biological Activity | Protein expression upregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| Experiment (4) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Silicon dioxide | |||||
| Biological Activity | Protein expression downregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12. | ||||
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