Details of the Drug Formulation (DFM)

General Information of DFM (ID: F24182)
Name
Cisatracurium 20mg/10ml injectable
Company
Cadila Healthcare Limited
Active Pharmaceutical Ingredient (API) Cisatracurium API Info click to show the detail info of this API
Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E04HFM DIG Info Benzenesulfonic acid Acidulant
E0NY1O DIG Info Benzyl alcohol Antimicrobial preservative ...
E0H2SC DIG Info Water Solvent
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Oxidoreductase (ORase)
            DBT Name: Indoleamine 2,3-dioxygenase 1 (IDO1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzyl alcohol
                    Biological Activity IC50 = 1400 nM (estimated based on the structural similarity with CHEMBL3763371 ) [1]
                    Structural Similarity Tanimoto coefficient = 0.848101266
                    Tested Species Homo sapiens (Human)
                    UniProt ID I23O1_HUMAN
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: Carbonic anhydrase (CA) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzenesulfonic acid
                    Biological Activity IC50 = 2000 nM (estimated based on the structural similarity with CHEMBL27601 ) [2]
                    Structural Similarity Tanimoto coefficient = 0.890625
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH1_HUMAN ; CAH2_HUMAN ; CAH3_HUMAN ; CAH4_HUMAN ; CAH5A_HUMAN ; CAH5B_HUMAN ; CAH7_HUMAN ; CAH8_HUMAN ; CAH9_HUMAN ; CAH10_HUMAN ; CAH11_HUMAN ; CAH12_HUMAN ; CAH13_HUMAN ; CAH14_HUMAN
References
1 O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. Eur J Med Chem. 2016 Jan 27; 108:564-576.
2 Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase. J Med Chem. 1993 Jul 23; 36(15):2134-41.

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