Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E01RHD)
DIG Name
Polyoxyl 20 cetyl ether
Synonyms    Click to Show/Hide the Synonyms of This DIG
9004-95-9; Cetomacrogol 1000; Brij-58; Polyoxyethylene (20) cetyl ether; 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol; NCGC00167551-01; Polyethylene glycol (20) hexadecyl ether; Brij(R) C20; CETOMACROGOL; Cetocire; Ceteth; Polyethylene glycol monocetyl ether; Romopal O; Collone AC; Lubrol W; Nikkol BC; Ethosperse CL20; Lipocol C2; Cirrasol ALN-WF; Ceteth 1; Ceteth 2; Ceteth-4; Ceteth-5; Ceteth-6; Ceteth-12; Ceteth-14; Ceteth-15; Ceteth-16; Ceteth-20; Ceteth-24; Ceteth-25; Ceteth-30; Ceteth-45; Emulgen 210; Berol 28; Emalex 105; Emalex 110; Emalex 115; Emalex 120; Nikkol BC 15TX; Nikkol BC 20TX; Nikkol BC 30; Nikkol BC 40; Ts 35 (polymer); Blaunon CH 340; Alfonic 16-8; Cetomacrogolum 1000; Emulgen 2200; Nonion P 208; Nonion P 210; Cetyl alcohol ethoxylate; Nissan nonion P 208; Nissan nonion P 210; Nissan nonion P 213; Nissan nonion P 220; UNII-IV5HOR6SHT; Ethoxylated cetyl alcohol; C 30 (polyoxyalkylene); Atlas G 3802; Atlas G 3816; UNII-LF9X1PN3XJ; BRIJ W1; Cetyl alcohol, ethoxylated; BC 8SY; OTsS 14; OTsS 20; UNII-5KLY4IOG20; UNII-5QU14HKY1U; UNII-G8K9HXI96S; UNII-I835H2IHHX; UNII-KF87ZXP48B; UNII-QWP6WMW083; UNII-XZ19O8Z6FM; Poly(oxyethylene)cetyl ether; Ethoxylated hexadecyl alcohol; UNII-0EV3Z43Y2I; UNII-2BB3L0ZO76; UNII-4TIK16VW41; UNII-9E0067TYQH; UNII-MK1889A3JS; UNII-N23GP0Q09W; UNII-WP14KA7G07; BRIJ 38; BRIJ 52; BRIJ 58; Polyoxyethylated cetyl alcohol; Cetyl poly(oxyethylene) ether; Polyethylene oxide cetyl ether; Ts 14; Ts 20; Ts 30; Ts 35; Ts 40; Ts 55; Ts 62; Ts A 16; UNII-33D0C5D77R; UNII-495CTZ441V; UNII-6X446K7Q0Y; UNII-94826GMB5B; UNII-GY15017H2B; UNII-W821XK704Z; Ethoxylated(20) cetyl alcohol; Poly(oxyethylene)palmityl ether; Polyethylene glycol cetyl ether; BC 2; BC 20 TX; BC 30 TX; BC 7; Cetomacrogolum 1000 [Latin]; NTS 40; Oxyethylenated hexadecyl alcohol; Poly(oxyethylene)hexadecyl ether; Poly(oxyethylene)monocetyl ether; UNII-4ST6952Q67; UNII-7Z6Q50934N; G 3802POE; G 3804POE; Hexadecylpoly(ethyleneoxy) ethanol; Polyethylene glycol palmityl ether; Polyethylene oxide hexadecyl ether; BC 10; BC 20; CA 16; Ceteth-1; OS 30; OS 55; Polyethylene glycol hexadecyl ether; UNII-683I13476K; BRIJ 56 purified; Brij52; Brij58; PEG-1 Cetyl ether; PEG-3 Cetyl ether; PEG-4 Cetyl ether; PEG-5 Cetyl ether; PEG-6 Cetyl ether; Polyethylene glycols monohexadecyl ether; Brij C10; PEG-12 Cetyl ether; PEG-14 Cetyl ether; PEG-15 Cetyl ether; PEG-16 Cetyl ether; PEG-20 Cetyl ether; PEG-24 Cetyl ether; PEG-25 Cetyl ether; PEG-30 Cetyl ether; PEG-45 Cetyl ether; IV5HOR6SHT; alpha-Hydroxy-omega-cetylpoly(ethylene oxide); Cetomacrogol 1000 BPC; LF9X1PN3XJ; G 3802; G 3816; G 3820; 5KLY4IOG20; 5QU14HKY1U; DSSTox_CID_26708; DSSTox_RID_81841; G8K9HXI96S; I835H2IHHX; KF87ZXP48B; QWP6WMW083; XZ19O8Z6FM; DSSTox_GSID_46708; Polyoxyl 20 cetostearyl ether; 0EV3Z43Y2I; 2BB3L0ZO76; 4TIK16VW41; 9E0067TYQH; MK1889A3JS; N23GP0Q09W; SCHEMBL1769850; WP14KA7G07; alpha-Hexadecyl-omega-hydroxy-poly(oxy-1,2-ethanediyl); CHEMBL2355804; DTXSID7046708; UNII-D6K7I18258; Polyoxyethylene (4) cetyl ether; Polyoxyethylene (6) cetyl ether; Cetomacrogol 1000 [INN:BAN]; Polyoxyethylene (10) cetyl ether; Polyoxyethylene (12) cetyl ether; Polyoxyethylene (14) cetyl ether; Polyoxyethylene (15) cetyl ether; Polyoxyethylene (16) cetyl ether; Polyoxyethylene (24) cetyl ether; Polyoxyethylene (25) cetyl ether; Polyoxyethylene (30) cetyl ether; Polyoxyethylene (45) cetyl ether; Polyoxyethylene monohexadecyl ether; 33D0C5D77R; 495CTZ441V; 6X446K7Q0Y; 94826GMB5B; GY15017H2B; W821XK704Z; Tox21_112546; MFCD00080892; POE (20) ISOHEXADECYL ETHER; Polyethylene glycol (5) cetyl ether; Polyethylene glycol 200 cetyl ether; Polyethylene glycol 300 cetyl ether; Polyethylene glycol 600 cetyl ether; Brij(R) 58, average Mn ~1124; AKOS030228645; Polyethylene glycol (14) cetyl ether; Polyethylene glycol (15) cetyl ether; Polyethylene glycol (16) cetyl ether; Polyethylene glycol (24) cetyl ether; Polyethylene glycol (25) cetyl ether; Polyethylene glycol (30) cetyl ether; Polyethylene glycol (45) cetyl ether; Polyethylene glycol 1000 cetyl ether; 4ST6952Q67; 7Z6Q50934N; D6K7I18258; Polyethylene glycol 1000 monocetyl ether; 683I13476K; FT-0623194; 1-Hexadecanol, monoether with polyethylene glycol; Glycols, polyethylene, monohexadecyl ether (8CI); Poly(oxy-1,2-ethanediyl), alpha-hexadecyl-omega-hydroxy-; 198563-32-5; 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60-icosaoxahexaheptacontan-1-ol
DIG Function
Emulsifying agent; Ointment base; Solubilizing agent; Surfactant
PubChem CID
2724259
Formula
C56H114O21
Canonical SMILES
CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChI
1S/C56H114O21/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17-58-19-21-60-23-25-62-27-29-64-31-33-66-35-37-68-39-41-70-43-45-72-47-49-74-51-53-76-55-56-77-54-52-75-50-48-73-46-44-71-42-40-69-38-36-67-34-32-65-30-28-63-26-24-61-22-20-59-18-16-57/h57H,2-56H2,1H3
InChIKey
NLMKTBGFQGKQEV-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2724259"></iframe>
3D MOL is not available 2D MOL
Physicochemical Properties Molecular Weight 1123.5 Topological Polar Surface Area 205
XlogP 4.5 Complexity 999
Heavy Atom Count 77 Rotatable Bond Count 74
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 21
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Oxidoreductase (ORase)
            DBT Name: Cytochrome P450 2E1 (CYP2E1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 247.1 uM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2E1_HUMAN
            DBT Name: Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 391.4 uM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2C9_HUMAN
            DBT Name: Debrisoquine 4-hydroxylase (CYP2D6) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 242.8 uM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2D6_HUMAN
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: Cholesterol 25-hydroxylase (CYP1A2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 211.5 uM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP1A2_HUMAN
References
1 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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