Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0F1GV)
DIG Name	Polyethylene glycol 2000
DIG Function	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Acetaminophen	API Info	Anaesthesia [ICD-11: 8E22]		[1]
Oxcarbazepine	API Info	Epilepsy [ICD-11: 8A60]		[2]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Diphenhydramine	API Info	Meniere disease [ICD-11: AB31]		[3]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Diclofenac	API Info	Knee osteoarthritis [ICD-11: FA01]		[4]
Phenylephrine	API Info	Juvenile rheumatoid arthritis [ICD-11: FA24]		[5]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Ibuprofen	API Info	Dysmenorrhea [ICD-11: GA34]		[6]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio < 90 % (tested by experiment)		[7]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Primary active transporter (PAT)
DBT Name: Multidrug resistance protein 2 (ABCC2)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio = 72 % (tested by experiment)		[8]
Tested Species	Homo sapiens (Human)
UniProt ID	MRP2_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio > 73 % (tested by experiment)		[9]
Tested Species	Homo sapiens (Human)
UniProt ID	MRP2_HUMAN
DBT Name: Multidrug resistance protein 1 (ABCB1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio = 40 % (tested by experiment)		[10]
Tested Species	Homo sapiens (Human)
UniProt ID	MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN

References
1	FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved oxcarbazepine from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved diclofenac from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved phenylephrine from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
7	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
8	Inhibition of human efflux transporter ABCC2 (MRP2) by self-emulsifying drug delivery system: influences of concentration and combination of excipients. J Pharm Pharm Sci. 2014;17(4):447-60.
9	Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.
10	Modulation of intestinal P-glycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies. Int J Pharm. 2006 Apr 26;313(1-2):49-56.

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