Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0M2LZ)
DIG Name
Aspartic acid
Synonyms    Click to Show/Hide the Synonyms of This DIG
L-aspartic acid; aspartic acid; 56-84-8; H-Asp-OH; L-aspartate; Asparagic acid; L-Aminosuccinic acid; (2S)-2-aminobutanedioic acid; aspartate; (S)-2-Aminosuccinic acid; Aspatofort; L-Asparagic acid; Asparaginic acid; L-Asparaginic acid; (S)-Aspartic acid; (2S)-Aspartic acid; (S)-Aminobutanedioic acid; L-Aspartinsaeure; L-Asparaginsaeure; L-Asparaginsyra; Aspartic acid, L-; Acidum asparticum; L-(+)-Aspartic acid; L-Asp; L-2-Aminobutanedioic acid; Aspartate, L-; Asparaginsaeure [German]; Aminosuccinic acid; Butanedioic acid, amino-, (S)-; Aspartic acid (VAN); Asparagic acid (VAN); Asparaginic acid (VAN); Acide aspartique [INN-French]; Acido aspartico [INN-Spanish]; (L)-ASPARTIC ACID; (+)-Aspartic acid; (S)-(+)-Aminosuccinic acid; FEMA No. 3565; CCRIS 6181; Acidum asparticum [INN-Latin]; 25608-40-6; HSDB 1430; L( )-Aminobernsteinsaeure; AI3-04461; NSC 3973; 2-aminosuccinic acid; MFCD00002616; BRN 1723530; Beta-L-Aspartic Acid; L-Aspartic acid-13C4; asp; (S)-(+)-Aspartic acid; (S)-2-aminobutanedioic acid; CHEMBL274323; CHEBI:17053; UNII-Z4FZM6CA61; 39162-75-9; (S)-Aspartate; (+)-Aspartate; 1-Amino-1,2-carboxyethane; (S)-Aminobutanedioate; (2S)-2-azanylbutanedioic acid; L(+)-Aspartic acid, 98+%; Asparaginsaeure; Polysuccinimide; Acido aspartico; Z4FZM6CA61; L-Asparticacid; Acide aspartique; Calcium dihydrogen di-L-aspartate; Polyaspartic acid; 6899-03-2; L-Aspartic acid homopolymer; Calcium diaspartate; Aspartic Acid [USAN:INN]; L-Aspartic acid, homopolymer; (S)-Aminosuccinic Acid; Poly-DL-succinimide; 55443-54-4; 4-04-00-02998 (Beilstein Handbook Reference); EINECS 200-291-6; L(+)-Aminobernsteinsaeure; Aminosuccinate; Asparagate; Asparatate; NSC-3973; l-aspartic-acid; L-Asparagate; L-Aminosuccinate; Aspartic acid [USAN:USP:INN]; (L)-Aspartate; aspartic acid group; alpha-Aminosuccinate; (2S)-Aspartate; Poly-L-asparticacid; EINECS 254-327-0; L-(+)-Aspartate; [3H]-L-aspartate; L-[14C]aspartate; L-Aspartic acid, 2; [3H]L-aspartic acid; (R)-2-aminosuccinate; (S)-2-aminosuccinate; Tocris-0214; [3h]-l-asp; (S)-amino-Butanedioate; alpha-Aminosuccinic acid; (S)-(+)-Aspartate; [3H]-L-aspartic acid; L-Aspartic acid (9CI); 2-Amino-3-methylsuccinate; Biomol-NT_000168; bmse000031; bmse000875; Aspartic acid (USP/INN); EC 200-291-6; L-Aspartic acid (JP17); SCHEMBL3231; (S)-amino-Butanedioic acid; L-Aspartic acid, >=98%; L-Aspartic acid, 99.0%; Lopac0_000133; Aspartic acid, L- (8CI); DL-Aspartic acid, homopolymer; L-Aspartic acid (H-Asp-OH); BPBio1_001128; GTPL3309; GTPL4534; DTXSID7022621; FEMA NO. 3656; aspartic acid (L-aspartic acid); BDBM18125; L-Aspartic acid, >=98%, FG; HMS3260K08; ZINC895032; .alpha.-Aminosuccinic acid, (L)-; HY-N0666; STR04614; Tox21_500133; ANW-32591; PDSP1_000819; PDSP2_000806; AKOS006239578; AKOS015853957; AM81585; CCG-204228; DB00128; LP00133; MCULE-6700641640; SDCCGSBI-0050121.P002; L-Aspartic acid (H-Asp-OH) USP grade; NCGC00024499-01; NCGC00024499-02; NCGC00024499-03; NCGC00024499-04; NCGC00024499-05; NCGC00024499-06; NCGC00024499-10; NCGC00260818-01; 27881-03-4; BP-13291; L-Aspartic acid, Vetec(TM) reagent grade; DB-029944; A0546; CS-0009701; EU-0100133; L-Aspartic acid, BioXtra, >=99% (HPLC); S5632; V1940; L-Aspartic acid, BioUltra, >=99.5% (T); A 9256; C-4546; C00049; D00013; M03000; L-Aspartic acid, SAJ special grade, >=99.0%; A817928; A824434; L-Aspartic acid, reagent grade, >=98% (HPLC); Q178450; SR-01000597734; SR-01000597734-3; F8889-8684; Z1270403519; A4B5FB11-A4B6-4D75-9860-2ACF670700B9; UNII-0O72R8RF8A component CKLJMWTZIZZHCS-REOHCLBHSA-N; UNII-28XF4669EP component CKLJMWTZIZZHCS-REOHCLBHSA-N; UNII-30KYC7MIAI component CKLJMWTZIZZHCS-REOHCLBHSA-N; Aspartic acid, European Pharmacopoeia (EP) Reference Standard; L-Aspartic acid, certified reference material, TraceCERT(R); Aspartic acid, United States Pharmacopeia (USP) Reference Standard; L-Aspartic acid, BioReagent, suitable for cell culture, suitable for insect cell culture; L-Aspartic acid, Pharmaceutical Secondary Standard; Certified Reference Material; L-Aspartic acid, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%; L-Aspartic acid, PharmaGrade, Ajinomoto, EP, JP, USP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell culture
DIG Function
Vaccine adjuvant
PubChem CID
5960
Formula
C4H7NO4
Canonical SMILES
C([C@@H](C(=O)O)N)C(=O)O
InChI
1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
InChIKey
CKLJMWTZIZZHCS-REOHCLBHSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5960"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 133.1 Topological Polar Surface Area 101
XlogP -2.8 Complexity 133
Heavy Atom Count 9 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: Cytochrome P450 2J2 (CYP2J2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 19498.45 nM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID EAA3_HUMAN
      Potential-driven transporter (PDT)
            DBT Name: Glutamate/aspartate transporter 1 (GLAST1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 9300 nM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID EAA1_HUMAN
            DBT Name: Glutamate/aspartate transporter 2 (GLT1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 32000 nM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID EAA2_HUMAN
            DBT Name: Excitatory amino-acid carrier 1 (EAAC1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 19498.45 nM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID EAA3_HUMAN
            DBT Name: Solute carrier SLC1A6 (EAAT4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 10964.78 nM (tested by experiment) [1]
                    Tested Species Rattus norvegicus (Rat)
                    UniProt ID EAA4_RAT
References
1 Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors. J Med Chem. 2018 Sep 13; 61(17):7741-7753.

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