Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0OF1T)
DIG Name
Malic acid
Synonyms    Click to Show/Hide the Synonyms of This DIG
malic acid; DL-malic acid; 6915-15-7; 2-Hydroxysuccinic acid; 2-Hydroxybutanedioic acid; 617-48-1; malate; Butanedioic acid, hydroxy-; hydroxysuccinic acid; Kyselina jablecna; Deoxytetraric acid; hydroxybutanedioic acid; Pomalus acid; Malic acid, DL-; Musashi-no-Ringosan; alpha-Hydroxysuccinic acid; Hydroxybutandisaeure; dl-Hydroxybutanedioic acid; Caswell No. 537; Monohydroxybernsteinsaeure; Succinic acid, hydroxy-; R,S(+-)-Malic acid; 2-Hydroxyethane-1,2-dicarboxylic acid; Kyselina jablecna [Czech]; FDA 2018; DL-2-hydroxybutanedioic acid; FEMA No. 2655; Kyselina hydroxybutandiova [Czech]; Malic acid [NF]; EPA Pesticide Chemical Code 051101; AI3-06292; MFCD00064212; (-)-Malic acid; butanedioic acid, 2-hydroxy-; BUTANEDIOIC ACID, HYDROXY-, (S)-; MLS000084707; CHEBI:6650; (+/-)-2-Hydroxysuccinic acid; (+-)-1-Hydroxy-1,2-ethanedicarboxylic acid; NSC25941; Malic acid (NF); Malic acid, L-; (+/-)-HYDROXYSUCCINIC ACID; Hydroxysuccinate; NSC-25941; Butanedioic acid, 2-hydroxy-, (2S)-; DL-Malate; Hydroxybutanedioate; E296; SMR000019054; DL-Apple Acid; DSSTox_CID_7640; DL-Malic acid, 99+%; (R)-Hydroxybutanedioic acid; (S)-Hydroxybutanedioic acid; DSSTox_RID_78538; DSSTox_GSID_27640; (+-)-Malic acid; Hydroxy Succinic Acid; R-Malic acid; Malicum acidum; FEMA Number 2655; Poly(malate); Malate homopolymer; Poly (L-malate); CAS-6915-15-7; CCRIS 2950; CCRIS 6567; L-(-)-MalicAcid; Malic acid L-(-)-form; HSDB 1202; DL-hydroxysuccinic acid; Kyselina hydroxybutandiova; EINECS 210-514-9; EINECS 230-022-8; NSC 25941; (+-)-Hydroxysuccinic acid; Aepfelsaeure; Deoxytetrarate; NSC 9232; NSC-9232; a-Hydroxysuccinate; Hydroxybutanedioic acid, (+-)-; R,SMalate; R,SMalic acid; H2mal; Hydroxybutanedioic acid homopolymer; 2-Hydroxysuccinate; R,S-Malic acid; Racemic malic acid; R,S-Malate; alpha-Hydroxysuccinate; .+-.-Malic acid; 143435-96-5; a-Hydroxysuccinic acid; PubChem20057; (+/-)-Malic acid; Opera_ID_805; 2-hydroxyl-succinic acid; DL-Malic acid, 99%; MALIC ACID,(DL); 2-Hydroxydicarboxylic acid; SCHEMBL856; 2-hydroxy-butanedioic acid; bmse000046; bmse000904; EC 210-514-9; EC 230-022-8; Malic acid-, (L-form)-; ACMC-1B8G6; DL-Malic acid, >=99%; HYOSCYAMINEHYDROBROMIDE; Oprea1_130558; Oprea1_624131; DL-Malic acid-2-[13C]; DL-HYDROXYSUCOINIC ACID; Butanedioic acid, (.+-.)-; DL(+/-)-MALIC ACID; GTPL2480; INS NO.296; 2-HYDROXY-SUCCINIC ACID; DL-HYROXYBUTANEDIOIC ACID; CHEMBL1455497; DTXSID0027640; BDBM92495; INS NO. 296; INS-296; DL-Malic acid-2,3,3-[d3]; DL-Malic acid, FCC, >=99%; HMS2358H06; HMS3371C13; 2-Hydroxyethane-1,2-dicarboxylate; DL-Malic acid, analytical standard; ACN-S004262; HY-Y1311; STR03457; Tox21_201536; Tox21_300372; ANW-43712; s9001; STL283959; AKOS000120085; AKOS017278471; (+/-)-HYDROXYBUTANEDIOIC ACID; AM81418; CCG-266122; DB12751; MCULE-5852208511; Butanedioic acid, hydroxy-, homopolymer; DL-Malic acid, ReagentPlus(R), 99%; NCGC00043225-02; NCGC00043225-03; NCGC00254259-01; NCGC00259086-01; 78644-42-5; AK-65243; AK-77850; AK-88657; DL-Malic acid, >=98% (capillary GC); SY003313; SY009804; DL-Malic acid, ReagentPlus(R), >=99%; 99-EP2269610A2; 99-EP2269983A1; 99-EP2269984A1; 99-EP2269986A1; 99-EP2269988A2; 99-EP2269989A1; 99-EP2269990A1; 99-EP2270006A1; 99-EP2270008A1; 99-EP2270011A1; 99-EP2270014A1; 99-EP2270505A1; 99-EP2272516A2; 99-EP2272827A1; 99-EP2272835A1; 99-EP2272844A1; 99-EP2275401A1; 99-EP2275404A1; 99-EP2275411A2; 99-EP2275413A1; 99-EP2277848A1; 99-EP2277858A1; 99-EP2281559A1; 99-EP2281563A1; 99-EP2281819A1; 99-EP2284160A1; 99-EP2284169A1; 99-EP2287155A1; 99-EP2287156A1; 99-EP2287160A1; 99-EP2287161A1; 99-EP2287162A1; 99-EP2289510A1; 99-EP2289879A1; 99-EP2289883A1; 99-EP2289890A1; 99-EP2292612A2; 99-EP2292617A1; 99-EP2292619A1; 99-EP2295401A2; 99-EP2295402A2; 99-EP2295406A1; 99-EP2295433A2; 99-EP2298731A1; 99-EP2298746A1; 99-EP2298747A1; 99-EP2298755A1; 99-EP2298757A2; 99-EP2298768A1; 99-EP2298772A1; 99-EP2298778A1; 99-EP2298779A1; 99-EP2301544A1; 99-EP2301922A1; 99-EP2301931A1; 99-EP2301937A1; 99-EP2301940A1; 99-EP2305219A1; 99-EP2305248A1; 99-EP2305257A1; 99-EP2305633A1; 99-EP2305641A1; 99-EP2305646A1; 99-EP2305651A1; 99-EP2305659A1; 99-EP2305663A1; 99-EP2305672A1; 99-EP2305673A1; 99-EP2305679A1; 99-EP2308839A1; 99-EP2308849A1; 99-EP2308850A1; 99-EP2308854A1; 99-EP2308857A1; 99-EP2308869A1; 99-EP2311809A1; 99-EP2311810A1; 99-EP2311811A1; 99-EP2311814A1; 99-EP2311818A1; 99-EP2311834A1; 99-EP2311842A2; 99-EP2314295A1; 99-EP2314574A1; 99-EP2314584A1; 99-EP2314585A1; 99-EP2314586A1; 99-EP2314588A1; 99-EP2316457A1; 99-EP2316458A1; 99-EP2316459A1; 99-EP2316825A1; 99-EP2316826A1; 99-EP2316827A1; 99-EP2316828A1; 99-EP2316831A1; 99-EP2371802A1; 99-EP2372017A1; DB-016133; DL-Malic acid, USP, 99.0-100.5%; CS-0017784; E-296; EU-0067046; FT-0605225; FT-0625484; FT-0625485; FT-0625539; FT-0632189; M0020; DL-Malic acid, SAJ first grade, >=99.0%; A19426; C00711; C03668; D04843; DL-Malic acid 1000 microg/mL in Acetonitrile; DL-Malic acid, Vetec(TM) reagent grade, 98%; M-0825; 21177-EP2314295A1; 92310-EP2305257A1; AB00443952-12; Malic acid, meets USP/NF testing specifications; 4-ethoxyphenyltrans-4-propylcyclohexanecarboxylate; L023999; Q190143; Q-201028; 0C9A2DC0-FEA2-4864-B98B-0597CDD0AD06; F0918-0088; Z940713496; Malic acid, United States Pharmacopeia (USP) Reference Standard; Malic acid, Pharmaceutical Secondary Standard; Certified Reference Material; DL-Malic acid, meets analytical specification of FCC, E296, 99-100.5% (alkalimetric); 104596-63-6
DIG Function
Acidulant; Antioxidant; Buffering agent; Complexing agent; Flavoring agent
PubChem CID
525
Formula
C4H6O5
Canonical SMILES
C(C(C(=O)O)O)C(=O)O
InChI
1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)
InChIKey
BJEPYKJPYRNKOW-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=525"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 134.09 Topological Polar Surface Area 94.8
XlogP -1.3 Complexity 129
Heavy Atom Count 9 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 10 Ear/mastoid process disease Click to Show/Hide
Diphenhydramine
 API Info
Meniere disease [ICD-11: AB31]
 [1]
       ICD Disease Classification 12 Respiratory system disease Click to Show/Hide
Guaifenesin
 API Info
Asthma [ICD-11: CA23]
 [2]
       ICD Disease Classification 13 Digestive system disease Click to Show/Hide
Sodium fluoride
 API Info
Periodontal disease [ICD-11: DA0C]
 [3]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: Carbonic anhydrase IV (CA4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Ki = 53700 nM (estimated based on the structural similarity with CHEMBL182856 ) [4]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH4_HUMAN
References
1 FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
2 FDA label for approved guaifenesin from the official website of the U.S. Food and Drug Administration.
3 FDA label for approved sodium fluoride from the official website of the U.S. Food and Drug Administration.
4 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.

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