Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00630)
Name
Sodium fluoride
Synonyms    Click to Show/Hide the Synonyms of This API
sodium fluoride; 7681-49-4; Florocid; Zymafluor; Sodium fluoride (NaF); Fluoride, sodium; Villiaumite; Floridine; Pediaflor; Sodium flouride; Sodium monofluoride; duraphat; Antibulit; Fluonatril; Fluoraday; Fluorident; Fluorigard; Fluorinse; Flurexal; Karidium; Koreberon; Liquiflur; Pergantene; Xaridium; Fluorol; Flursol; Luride; Ossalin; sodium;fluoride; Natrium fluoride; Roach salt; Flura Drops; Neutra Care; Minute-Gel; Osteopor-F; T-Fluoride; Fungol B; Les-Cav; Sodium hydrofluoride; Alcoa sodium fluoride; Sodium fluorure; Fluorid sodny; Fluorure de sodium; Sodium fluoride (Na2F2); Sodium fluoride cyclic dimer; NCI-C55221; FDA 0101; Fluor-A-day; MFCD00003524; UNII-8ZYQ1474W7; CHEBI:28741; CHEMBL1528; 8ZYQ1474W7; NSC-77385; Chemifluor; Flozenges; Fluorineed; Fluoritab; Fluorocid; Flurcare; Gelution; Iradicav; Karigel; Lemoflur; Nufluor; Pedident; Pennwhite; Predent; Rafluor; Studafluor; Nafeen; Rescue squad; Kari-rinse; NaFpak; Super-dent; Thera-flur; Cavi-trol; Flura-gel; Flura-loz; Na frinse; Point two; Luride lozi-tabs; Phos-Flur; Stay-Flo; Fluor-O-kote; Thera-flur-N; Luride SF; Luride-SF; Lea-Cov; SO-Flo; Trisodium trifluoride; F1-Tabs; Caswell No. 769; osteofluor; Sodium fluoride, for biochemistry; Duofluorid; Fluorid sodny [Czech]; Apoflux; Ethedent; Fludent; GEL II; Sodium fluoride [ISO]; Sodium fluoride, 97%, extra pure; Sodium fluorure [French]; Sodium fluoride, 99+%, for analysis; Fluorure de sodium [French]; Sodium fluoride, solid (DOT); CCRIS 1573; Sodium fluoride, 99+%, ACS reagent, powder; HSDB 1766; Fluorure de sodium [ISO-French]; Prevident 5000 Plus; EINECS 231-667-8; NSC 77385; UN1690; EPA Pesticide Chemical Code 075202; Sodium fluoride [USP:JAN]; Dentiplus; Sodium fiuoride; AI3-01500; Fluorigard Daily; Fluor Ret; Point-Two; Fluorigard Weekly; NaFril Ret; Fluorinse (TN); En-De-Kay; Pediaflor; Zymafluor; Sodium fluoride, solid; Sodium fluoride, as F; ACMC-1BI1W; Sodium Fluoride ACS Grade; WLN: NA F; EC 231-667-8; Sodium fluoride (JAN/USP); Sodium fluoride, Optical Grade; DTXSID2020630; HY-B1766; NSC77385; BDBM50209223; KM1797; AKOS024438093; CS-5131; DB09325; Sodium fluoride [UN1690] [Poison]; Sodium fluoride, 200mM aqueous solution; Sodium fluoride, 99.995% (metals basis); FT-0645095; FT-0688141; C08142; D00943; P00019; Sodium Fluoride, Trace metals grade, 99.99%; A838842; Q407520; Sodium fluoride, 99.99% (metals basis), 3-6mm pieces
Clinical Status
Approved
Disease Indication Periodontal disease ICD-11: DA0C [1]
PubChem CID
5235
Formula
FNa
Canonical SMILES
[F-].[Na+]
InChI
1S/FH.Na/h1H;/q;+1/p-1
InChIKey
PUZPDOWCWNUUKD-UHFFFAOYSA-M
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5235"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 41.988 Topological Polar Surface Area 0
XlogP N.A. Complexity 2
Heavy Atom Count 2 Rotatable Bond Count 0
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 1
Full List of Drug Formulations (DFMs) Containing This API
          Sodium fluoride 1.1 mg tablet Click to Show/Hide the Full List of Formulation(s):          6 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 27; Fd&c blue no. 1; Magnesium stearate; Mannitol; Sucrose; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Chewable Tablet
                   Company PureTek Corporation
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [2]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Malic acid; Sucralose; Magnesium stearate; Citric acid monohydrate; Talc; Xylitol; Cellulose, microcrystalline
                   Dosage Form Chewable Tablet
                   Company Sancilio & Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [5]
Malic acid DIG Info Carbonic anhydrase IV (Ki = 53700 nM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Saccharin; Lactose, unspecified form; Magnesium stearate; Grape
                   Dosage Form Chewable Tablet
                   Company Mayne Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Benzosulfimide DIG Info Carbonic anhydrase VII (Ki = 10 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Saccharin sodium anhydrous; Magnesium stearate
                   Dosage Form Chewable Tablet
                   Company Fluoritab Corporation
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Saccharin sodium anhydrous DIG Info Carbonic anhydrase I (Ki = 18540 nM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company Kirkman Group
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Grape; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company H2-Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Sodium fluoride 0.55 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous citric acid; Malic acid; Sucralose; Magnesium stearate; Talc; Xylitol; Microcrystalline cellulose
                   Dosage Form Chewable Tablet
                   Company Sancilio & Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [5]
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [6]
Malic acid DIG Info Carbonic anhydrase IV (Ki = 53700 nM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 27; Magnesium stearate; Mannitol; Sucrose; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Chewable Tablet
                   Company PureTek Corporation
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [2]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Malic acid; Sucralose; Magnesium stearate; Citric acid monohydrate; Talc; Xylitol; Cellulose, microcrystalline
                   Dosage Form Chewable Tablet
                   Company Sancilio & Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [5]
Malic acid DIG Info Carbonic anhydrase IV (Ki = 53700 nM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Sodium fluoride 2.2 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Magnesium stearate; Mannitol; Sucrose; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Chewable Tablet
                   Company PureTek Corporation
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Malic acid; Sucralose; Magnesium stearate; Citric acid monohydrate; Talc; Xylitol; Cellulose, microcrystalline
                   Dosage Form Chewable Tablet
                   Company Sancilio & Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [5]
Malic acid DIG Info Carbonic anhydrase IV (Ki = 53700 nM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Saccharin; Lactose, unspecified form; D&c red no. 7; Magnesium stearate; Cherry
                   Dosage Form Chewable Tablet
                   Company Mayne Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Benzosulfimide DIG Info Carbonic anhydrase VII (Ki = 10 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Saccharin sodium anhydrous; Magnesium stearate
                   Dosage Form Chewable Tablet
                   Company Fluoritab Corporation
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Saccharin sodium anhydrous DIG Info Carbonic anhydrase I (Ki = 18540 nM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c red no. 7; Magnesium stearate; Cherry; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company H2-Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Sodium fluoride 2.21 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Saccharin sodium
                   Dosage Form Chewable Tablet
                   Company Kirkman Group
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
References
1 FDA label for approved sodium fluoride from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
5 Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose. ACS Med Chem Lett. 2018 May 10; 9(7):657-661.
6 PubChem BioAssay data set.
7 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.
8 A Sweet Combination: Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII. J Med Chem. 2020 Jan 9; 63(1):321-333.
9 Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15; 17(14):5054-8.

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