Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0QA3M)
DIG Name
Polyethylene glycol 200
DIG Function
Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 15 Musculoskeletal/connective-tissue disease Click to Show/Hide
Nabumetone
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [1]
       ICD Disease Classification 16 Genitourinary system disease Click to Show/Hide
Darifenacin
 API Info
Overactive bladder [ICD-11: GC50]
 [2]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Oxidoreductase (ORase)
            DBT Name: Albendazole monooxygenase (CYP3A4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Inhibition ratio < 60 % (tested by experiment) [3]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
References
1 FDA label for approved nabumetone from the official website of the U.S. Food and Drug Administration.
2 FDA label for approved darifenacin from the official website of the U.S. Food and Drug Administration.
3 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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