Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0VX5C)
DIG Name
DL-alpha-tocopherol
Synonyms    Click to Show/Hide the Synonyms of This DIG
DL-ALPHA-TOCOPHEROL; 10191-41-0; VITAMIN E; alpha-tochopherol; all-rac-alpha-Tocopherol; UNII-7QWA1RIO01; 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol; 7QWA1RIO01; CHEMBL49563; .alpha.-Tocopherol; 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-; d-.alpha.-Tocopherol; Ephanyl; 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol; 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-; 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol; Evitaminum; Profecundin; Syntopherol; Waynecomycin; Almefrol; Emipherol; Epsilan; Etamican; Tokopharm; Vascuals; Vitayonon; Etavit; Ilitia; Evion; alpha Tocopherol; Vitaplex E; Eprolin S; Spavit E; ido-E; Endo E; Vita E; Lan-E; Med-E; Antisterility vitamin; 1406-18-4; Vi-E; 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-ol; Tocopheroxy radical; Tocopheroxyl radical; alpha-Tocopherol, DL-; 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol; (+-)-alpha-Tocopherol; SR-05000001813; CCRIS 5853; DL-Tocopherol; MFCD00072051; .alpha.-Tokoferol; .alpha. Tocopherol; DL-alpha tocopherol; EINECS 233-466-0; 5,8-Trimethyltocol; Vitamin E DL-alpha; Tocopherol (JP17); BRN 0094012; dl-.alpha.-Tocopherol; Spectrum_001195; DL-all-rac-A-Tocopherol; Spectrum2_000722; Spectrum3_001338; Spectrum4_001771; Spectrum5_000381; (??)-??-Tocopherol; DL-5,7,8-trimethyltocol; EC 233-466-0; SCHEMBL22303; BSPBio_003095; KBioGR_002282; KBioSS_001675; SPECTRUM310039; (all-R)-.alpha.-Tocopherol; 113085-06-6; 5-17-04-00168 (Beilstein Handbook Reference); DivK1c_000533; SPBio_000644; alpha-Tocopherol, >=95.5%; DTXSID8021355; SCHEMBL14315133; (.+-.)-Med-E; (.+/-.)-.alpha.-Tocopherol; CHEBI:93909; HMS501K15; HSDB 8261; KBio1_000533; KBio2_001675; KBio2_004243; KBio2_006811; KBio3_002315; (2R,8'R)-.alpha.-Tocopherol; DL-alpha-Tocopherol (Vitamin E); Vitamin E (DL-alpha-Tocopherol); NINDS_000533; HMS1923I03; HMS2091C11; Pharmakon1600-00310039; (2R,4'S,8'R)-; A-Tocopherol; (2R,4'S,8'S)-; A-Tocopherol; (2S,4'R,8'R)-; A-Tocopherol; (2S,4'R,8'S)-; A-Tocopherol; (2S,4'S,8'R)-; A-Tocopherol; (2S,4'S,8'S)-; A-Tocopherol; 78656-13-0; 79434-82-5; 79434-83-6; C29H50O2 (DL-alpha-tocopherol); NSC20812; NSC82623; BBL027614; BDBM50436220; CCG-40162; NSC-20812; NSC-82623; NSC755839; s6104; SBB057399; STL372809; all-rac-alpha-Tocopherol (Vitamin E); AKOS015960364; DB14476; HY-W020044; MCULE-4241435740; NSC-755839; SDCCGMLS-0066634.P001; 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol; IDI1_000533; NCGC00095254-01; NCGC00095254-02; NCGC00095254-03; NCGC00095254-05; NCGC00095254-06; AC-10544; SY012869; SY057064; VS-08569; SBI-0051261.P003; AB0211519; ( inverted exclamation markA)-; A-Tocopherol; (+/-)-alpha-Tocopherol, analytical standard; CS-0031997; FT-0600386; FT-0624406; FT-0625430; FT-0696605; D02332; AB00051898_02; SR-05000001813-1; SR-05000001813-2; (+/-)-alpha-Tocopherol, synthetic, >=96% (HPLC); (+/-)-alpha-Tocopherol, tested according to Ph.Eur.; BRD-A82892199-001-01-7; Q27165663; (+/-)-alpha-Tocopherol, SAJ special grade, >=96.0%; F0001-2420; UNII-R0ZB2556P8 component GVJHHUAWPYXKBD-UHFFFAOYSA-N; 7A4513C3-131C-41D4-B6A0-7ED994AC2947; alpha-Tocopherol, British Pharmacopoeia (BP) Reference Standard; DL-alpha-Tocopherol (Vitamin E) 10 microg/mL in Acetonitrile; 2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol #; alpha-Tocopherol, European Pharmacopoeia (EP) Reference Standard; Alpha Tocopherol, United States Pharmacopeia (USP) Reference Standard; Alpha Tocopherol, Pharmaceutical Secondary Standard; Certified Reference Material; (+/-)-alpha-Tocopherol (Vitamin E) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material; [It may consist of d- or dl-.alpha.-tocopherol (C29H50O2), d- or dl-.alpha.-tocopheryl acid succinate (C33H54O5), mixed tocopherols concentrate, or d-.alpha.-tocopheryl acetate concentrate.]; 16826-11-2; 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, radical ion(1+), (2R-(2R*(4R*,8R*)))-; 2H-1-Benzopyran-6-ol,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, [2R*(4R*,8R*)]-(.+-.)-; 2H-1-Benzopyran-6-ol,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, [2R-[2R*(4R*,8R*)]]-
DIG Function
Antioxidant
PubChem CID
2116
Formula
C29H50O2
Canonical SMILES
CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C
InChI
1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
InChIKey
GVJHHUAWPYXKBD-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2116"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 430.7 Topological Polar Surface Area 29.5
XlogP 10.7 Complexity 503
Heavy Atom Count 31 Rotatable Bond Count 12
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 04 Immune system disease Click to Show/Hide
Cetirizine
 API Info
Allergy [ICD-11: 4A80]
 [1]
       ICD Disease Classification 08 Nervous system disease Click to Show/Hide
Acetaminophen
 API Info
Anaesthesia [ICD-11: 8E22]
 [2]
Tapentadol
 API Info
Neuropathic pain [ICD-11: 8E43]
 [3]
       ICD Disease Classification 14 Skin disease Click to Show/Hide
Isotretinoin
 API Info
Acne vulgaris [ICD-11: ED80]
 [4]
       ICD Disease Classification 15 Musculoskeletal/connective-tissue disease Click to Show/Hide
Cyclosporin A
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [5]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Hydrolase (HDase)
            DBT Name: Presenilin 1 (PSEN1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 > 100000 nM (tested by experiment) [6]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PSN1_HUMAN
References
1 FDA label for approved cetirizine from the official website of the U.S. Food and Drug Administration.
2 FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
3 FDA label for approved tapentadol from the official website of the U.S. Food and Drug Administration.
4 FDA label for approved isotretinoin from the official website of the U.S. Food and Drug Administration.
5 FDA label for approved cyclosporin A from the official website of the U.S. Food and Drug Administration.
6 Membrane anchoring -secretase modulators with terpene-derived moieties. Bioorg Med Chem Lett. 2013 Jul 1; 23(13):3852-6.

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