General Information of DFM (ID: F09420)
Name	Guaifenesin 200 mg tablet
Company	Enzymatic Therapy
Active Pharmaceutical Ingredient (API)	Guaifenesin		API Info click to show the detail info of this API
	Asthma		ICD-11: CA23	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0CR4U	DIG Info	Aminobenzoic acid	Antioxidant

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Hydrolase (HDase)
DBT Name: Acetylcholinesterase (ACHE)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Aminobenzoic acid
Biological Activity	IC50 = 35.2 nM (tested by experiment)					[1]
Tested Species	Rattus norvegicus (Rat)
UniProt ID	ACES_RAT
Lyase/isomerase/ligase (L/I/G)
DBT Name: Cytochrome P450 1B1 (CYP1B1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Aminobenzoic acid
Biological Activity	IC50 > 120000 nM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CP1B1_HUMAN

References
1	Synthesis and evaluation of novel 4-[(3H,3aH,6aH)-3-phenyl)-4,6-dioxo-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazol-5(3H,6H,6aH)-yl]benzoic acid derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents. Bioorg Med Chem. 2012 Jan 1; 20(1):521-30.
2	Aryl morpholino triazenes inhibit cytochrome P450 1A1 and 1B1. Bioorg Med Chem Lett. 2016 Jul 15; 26(14):3243-3247.

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