Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00307)
Name
Guaifenesin
Synonyms    Click to Show/Hide the Synonyms of This API
guaifenesin; 93-14-1; Guaiphenesin; Guaiacol glyceryl ether; Glycerol guaiacolate; GLYCERYL GUAIACOLATE; Guaiphenesine; Methphenoxydiol; Aeronesin; Breonesin; Bronchol; Aresol; 3-(2-methoxyphenoxy)propane-1,2-diol; Propanosedyl; Calmipan; Cortussin; Dorassin; Flartussin; Guaiacuran; Guaiacurane; Guaiamar; Guaianesin; Guaiphesin; Myocaine; Myoscain; Creson; Gaiamar; Hytuss; Mucinex; Myocain; Reduton; Glycerin guaiacolate; Glyceryl guaiacol; Methoxypropanediol; Metossipropandiolo; Metfenossidiolo; Amonidrin; Glycotuss; Guajacuran; Guajamar; Guayanesin; Guiaphenesin; Hustodil; Mintosyl; Miocaina; Miocurin; Miorelax; Mucostop; Muskurelax; Myorelax; Myoscaine; Neuroton; Neurotone; Reorganin; Respenyl; Ritussin; Robitussin; Tenntuss; Glyceryl guaicolate; Glyceryl guiacolate; Guanar; Oresol; Oreson; Respil; Sirotol; 3-(o-Methoxyphenoxy)-1,2-propanediol; Guaiacol glycerol ether; Guaiacolglicerinetere; Guaia-rom; Relaxil G; Relaxyl-G; Guaicol glyceryl ether; Gnaifenesin; Guaifenesine; Glyceryl guaiacyl ether; Guaiacyl glyceryl ether; Guaicol glycerine ether; Hustosil; 3-(2-Methoxyphenoxy)-1,2-propanediol; Organidin NR; o-Methoxyphenyl glyceryl ether; Glycero-guaiacol ether; 1,2-Propanediol, 3-(2-methoxyphenoxy)-; Guaiacol glycerin ether; Guaifenesinum; Amonidren; Pneumomist; Trecid; Glycerylguaiacol; Glycerin monoguaiacol ether; Guajacol-glycerinaether; Glyceryl guaiacol ether; 3-o-Methoxyphenoxypropane 1:2-diol; Glyceryl guaiacolate ether; Glycerol mono(2-methoxyphenyl) ether; Actifed C; Guaiacolic acid, ester with glycerol; MY 301; alpha-Glyceryl guaiacol ether; 1,2-Dihydroxy-3-(2-methoxyphenoxy)propane; alpha-Glyceryl guaiacolate ether; 1,2-Propanediol, 3-(o-methoxyphenoxy)-; Glycerol-alpha-guajakolether; component of Quibron; 3-(o-Methoxyphenoxy)-propanediol-1,2; component of Hycotuss; Glycerol .alpha.-guiacyl ether; .alpha.-Glyceryl guaiacol ether; Glycerol .alpha.-guaiacyl ether; Guajacol-.alpha.-glycerin-ether; component of Brondecon; .alpha.-Glyceryl guaiacolate ether; Glycerol .alpha.-monoguaiacol ether; component of Quibron Plus; MFCD00016873; 1,2,3-Propanetriol, ether with 2-methoxyphenol; Guaifenesin (Guaiphenesin); Glycerol .alpha.-(o-methoxyphenyl)ether; Glycerol .alpha.-(2-methoxyphenyl) ether; component of Colrex Expectorant; NSC62112; NSC-62112; Equicol; Glycodex; 3-(2-Methoxy-phenoxy)-propane-1,2-diol; DSSTox_CID_3114; Colrex expectorant; DSSTox_RID_76881; DSSTox_GSID_23114; Guaifenesina; Tenntus; Tussin; Glycerinmonoguaiacol ether; Benylin-E; Lufyllin-GG; Aether glycerinoguaiacolicus; Guaifenesine [INN-French]; Guaifenesinum [INN-Latin]; Guajacol-alpha-glycerinether; Tedral Expectorant; (component of) Deconsal II; Glycerol alpha-guiacyl ether; Guaifenesina [INN-Spanish]; Glycerol alpha-guaiacyl ether; MY-301; Glycerol alpha-monoguaiacol ether; Glycerol-alpha-monoguaiacol ether; Guajacol-glycerinaether [German]; HSDB 3089; SR-01000737186; Glycerol mono(2-methoxyphenyl)ether; Guaifenesin(Guaiphenesin); EINECS 202-222-5; Glycerol-alpha-guajakolether [Czech]; NSC 62112; Glycerol alpha-(o-methoxyphenyl)ether; Glycerol alpha-(o-methoxyphenyl) ether; Glycerol alpha-(2-methoxyphenyl) ether; BRN 2049375; glycerin ether; AI3-24947; Guaifenesin-d3; Q-Tussin; Guaifenesin,(S); CAS-93-14-1; NCGC00016350-01; Hustosil (TN); Prestwick_231; Entex (Salt/Mix); HUMABID; Dimacol (Salt/Mix); Kwelcof (Salt/Mix); (2R)-3-(2-methoxyphenoxy)propane-1,2-diol; Guaifenesin Dc 95%; Hycotuss (Salt/Mix); Guaifenesin [USAN:USP:INN:BAN:JAN]; Brondecon (Salt/Mix); Congestac (Salt/Mix); Triaminic (Salt/Mix); Dilor G (Salt/Mix); PubChem21966; Spectrum_000835; Pneumomist (Salt/Mix); Q-Tussin (Salt/Mix); Glycerol-a-guajakolether; Mucinex D (Salt/Mix); ROBITUSSIN (TN); Glycerol a-guiacyl ether; Tussar-2 (Salt/Mix); Brexin EX (Salt/Mix); Tussar SF (Salt/Mix); a-Glyceryl guaiacol ether; Glycerol a-guaiacyl ether; Mucinex DM (Salt/Mix); Prestwick0_000776; Prestwick1_000776; Prestwick2_000776; Prestwick3_000776; Spectrum2_001104; Spectrum3_000444; Spectrum4_000566; Spectrum5_000758; Lufyllin-GG (Salt/Mix); Naldecon-EX (Salt/Mix); (+-)-3-(o-Methoxyphenoxy)-1,2-propanediol; CHEMBL980; Theolair Plus (Salt/Mix); Robitussin CF (Salt/Mix); SCHEMBL4321; a-Glyceryl guaiacolate ether; Neothylline-GG (Salt/Mix); Oprea1_193170; Pneumotussin HC (Salt/Mix); WLN: Q1YQ1OR BO1; 1, 3-(o-methoxyphenoxy)-; Bronkaid Caplets (Salt/Mix); BSPBio_000852; BSPBio_002088; Glycerol a-monoguaiacol ether; KBioGR_000972; KBioSS_001315; Slo-Phyllin GG (Salt/Mix); 1,2-Propanediol, 3-(2-methoxyphenoxy)- (+-)-; 4-06-00-05576 (Beilstein Handbook Reference); MLS000028402; 1, 3-(2-methoxyphenoxy)-; DivK1c_000248; SPECTRUM1500321; Glycerol-.alpha.-guajakolether; SPBio_001208; SPBio_002791; PV Tussin Tablet (Salt/Mix); Tedral Expectorant (Salt/Mix); BPBio1_000938; CHEBI:5551; GTPL7617; Guaifenesin (JP17/USP/INN); DTXSID5023114; Tussi-Organidin NR (Salt/Mix); HMS500M10; KBio1_000248; KBio2_001315; KBio2_003883; KBio2_006451; KBio3_001308; Contac Cough Formula (Salt/Mix); Ru-Tuss DE Tablets (Salt/Mix); Glycerol a-(o-methoxyphenyl)ether; NINDS_000248; HMS1570K14; HMS1920B15; HMS2090K20; HMS2091H21; HMS2097K14; HMS2231M20; HMS3369E03; HMS3369N15; HMS3651I17; HMS3714K14; Isoclor Expectorant C (Salt/Mix); Pharmakon1600-01500321; Polaramine Expectorant (Salt/Mix); CVT-2534; Glycerol a-(2-methoxyphenyl) ether; HY-B0264; Tox21_110389; Tox21_302094; ANW-43892; BBL009981; CCG-39687; NSC757052; STK365152; Glycerol, 1-(2-methoxyphenyl) ether; AKOS005435152; Tox21_110389_1; ACN-046918; DB00874; KS-5306; MCULE-8909929116; NSC-757052; Guaiacol glyceryl ether, >=98% (GC); IDI1_000248; 3-(2-Methoxyphenoxy)-1, 2-propanediol; NCGC00094689-01; NCGC00094689-02; NCGC00094689-03; NCGC00094689-04; NCGC00094689-06; NCGC00255343-01; AC-26819; AK402920; SMR000058387; SBI-0051397.P003; AB00052006; FT-0613565; FT-0669064; ST50330628; SW196538-3; 1,3-Propanetriol, ether with 2-methoxyphenol; D00337; J10304; 3-(2-Methoxyphenoxy)-1,2-propanediol, 99+%; 3-{[2-(methyloxy)phenyl]oxy}propane-1,2-diol; AB00052006-10; AB00052006-11; AB00052006_12; AB00052006_13; Q420682; 3 - (2 - Methoxyphenoxy) - 1, 2 - propanediol; SR-01000737186-2; SR-01000737186-3; W-100252; BRD-A90515964-001-05-8; BRD-A90515964-001-09-0; Guaifenesin, European Pharmacopoeia (EP) Reference Standard; ( inverted exclamation markA)-3-(o-Methoxyphenoxy)-1,2-propanediol; Guaifenesin, United States Pharmacopeia (USP) Reference Standard; Guaifenesin, Pharmaceutical Secondary Standard; Certified Reference Material
Clinical Status
Approved
Disease Indication Asthma ICD-11: CA23 [1]
PubChem CID
3516
Formula
C10H14O4
Canonical SMILES
COC1=CC=CC=C1OCC(CO)O
InChI
1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3
InChIKey
HSRJKNPTNIJEKV-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3516"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 198.22 Topological Polar Surface Area 58.9
XlogP 1.4 Complexity 151
Heavy Atom Count 14 Rotatable Bond Count 5
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Guaifenesin 200 mg tablet Click to Show/Hide the Full List of Formulation(s):        16 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Glycerin; Croscarmellose sodium; Povidone; Silicon dioxide; Acacia; Althaea officinalis root; Carnauba wax; Fenugreek seed; Hypromellose, unspecified; Icodextrin; Microcrystalline cellulose; Verbascum thapsus leaf
                   Dosage Form Oral Tablet
                   Company Schwabe North America
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Glycerin; Croscarmellose sodium; Povidone; Silicon dioxide; Acacia; Althaea officinalis root; Carnauba wax; Fenugreek seed; Hypromellose, unspecified; Icodextrin; Microcrystalline cellulose; Mullein leaf
                   Dosage Form Oral Tablet
                   Company Schwabe North America
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c red no. 40; Maltodextrin; Magnesium stearate; Povidone; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Richmond Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c red no. 40; Maltodextrin; Magnesium stearate; Povidone; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Major Pharmaceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c red no. 40; Maltodextrin; Magnesium stearate; Povidone; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Cardinal Health; Select Brand
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c red no. 40; Maltodextrin; Magnesium stearate; Povidone; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Contract Pharmacal
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c red no. 40; Maltodextrin; Magnesium stearate; Povidone; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company AvPAK; Qualitest Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c red no. 30; Magnesium stearate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Contract Pharmacal
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c red no. 30; Maltodextrin; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Povidone k15; Starch, corn
                   Dosage Form Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c red no. 30; Maltodextrin; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Qualitest Pharmaceuticals; Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c red no. 30; Maltodextrin; Magnesium stearate; Silicon dioxide; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c red no. 40; Maltodextrin; Magnesium stearate; Povidone; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Fd&c red no. 40; Maltodextrin; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Povidones
                   Dosage Form Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Povidone; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Cellulose, microcrystalline; Povidones
                   Dosage Form Oral Tablet
                   Company AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Aminobenzoic acid; Althaea officinalis root; Cellulose, microcrystalline; Fenugreek leaf; Mullein leaf
                   Dosage Form Oral Tablet
                   Company Enzymatic Therapy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Aminobenzoic acid DIG Info Acetylcholinesterase (IC50 = 35.2 nM) [11]
          Guaifenesin 400 mg tablet Click to Show/Hide the Full List of Formulation(s):        26 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Fd&c blue no. 1; Magnesium stearate; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company Sam's West; Target Corporation
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Fd&c blue no. 1; Magnesium stearate; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Family Dollar
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Fd&c blue no. 1; Magnesium stearate; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
                   Dosage Form Oral Tablet
                   Company Army & Air Force Exchange Service; Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Fd&c blue no. 1; Magnesium stearate; Povidone; Silicon dioxide; Hypromelloses; Polyethylene glycols; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Rite Aid
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Fd&c blue no. 1; Magnesium stearate; Silicon dioxide; Hypromellose, unspecified; Microcrystalline cellulose; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form Oral Tablet
                   Company Harmon Stores
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Fd&c blue no. 1; Magnesium stearate; Silicon dioxide; Hypromellose, unspecified; Microcrystalline cellulose; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form Oral Tablet
                   Company Better Living Brands
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Fd&c blue no. 1; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Povidones; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Nash Finch Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Fd&c blue no. 1; Magnesium stearate; Silicon dioxide; Acetaminophen; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form Oral Tablet
                   Company L.N.K. International
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Povidone; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Advance Pharmaceutical; Richmond Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Povidone; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Sunrise Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Povidone; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a corn
                   Dosage Form Oral Tablet
                   Company Avema Pharma Solutions; Family Dollar; Greenbrier International; Lidl US; Pld Acquisitions L L C Av Ma Pharma Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Povidone; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Avema Pharma Solutions; Time Cap Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Fd&c blue no. 1; Magnesium stearate; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Sam's West
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Povidones; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Gericare Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Povidone; Cellulose, microcrystalline; Colloidal silicon dioxide; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Simpex Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Povidones; Sodium starch glycolate type a corn
                   Dosage Form Oral Tablet
                   Company Allegiant Health; Chain Drug Consortium
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Silicon dioxide; Copovidone
                   Dosage Form Oral Tablet
                   Company Amerisource Bergen; CVS Pharmacy; Cardinal Health; Chain Drug Marketing Association; Kinray; McKesson; Medicine Shoppe International; Reese Pharmaceutical; Select Brand; Shopko; SuperValu
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Silicon dioxide; Copovidone
                   Dosage Form Oral Tablet
                   Company Chain Drug Consortium
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Povidones; Sodium starch glycolate type a corn
                   Dosage Form Oral Tablet
                   Company Good Sense; Kroger; P & L Development; Target Corporation; Western Family Foods
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 20 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Silicon dioxide; Microcrystalline cellulose; Povidone, unspecified; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 21 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Povidones
                   Dosage Form Oral Tablet
                   Company SJ Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 22 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Povidones; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Clinical Solutions Wholesale; Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 23 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Maltodextrin; Fd&c blue no. 1; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Povidones; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Major Pharmaceuticals; Safeway; Wal-Mart Stores
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 24 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Povidone k29/32; Sodium starch glycolate type a corn
                   Dosage Form Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 25 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company HealthLife of USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 26 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Magnesium stearate; Cellulose, microcrystalline; Silicon dioxide, colloidal
                   Dosage Form Oral Tablet
                   Company Reese Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
          Guaifenesin 100 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Malic acid; Sucralose; Ethylene glycol; Croscarmellose sodium; Lecithin, soybean; Silicon dioxide; Ethylcellulose (4 mpa.s); Methacrylic acid - methyl methacrylate copolymer (1:2); Sodium starch glycolate type a potato
                   Dosage Form Chewable Tablet
                   Company ProPhase Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [7]
Malic acid DIG Info Carbonic anhydrase IV (Ki = 53700 nM) [8]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
Soybean lecithin DIG Info Albendazole monooxygenase (IC50 = 6.61 mg.mL-1) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Aspartame; Magnesium stearate; Povidone k30; Silicon dioxide; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Fortune Pharmacal
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Guaifenesin 1200 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Fd&c blue no. 1; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Copovidone k25-31; Hypromelloses; Povidones
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company American Sales Company; Amerisource Bergen; CVS Pharmacy; Cardinal Health; DZA Brands; Dolgencorp; H E B; Harris Teeter; Hy-Vee; Kmart Corporation; Kroger Company; L. Perrigo Company; McKesson; Meijer; Rite Aid; Safeway; Sam's West; Shopko; SuperValu; Target Corporation; Topco Associates; Wal-Mart Stores; Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Maltodextrin; Fd&c blue no. 1; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Copovidone k25-31; Hypromelloses; Povidones
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company Perrigo New York
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Guaifenesin 600 mg tablet Click to Show/Hide the Full List of Formulation(s):        13 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Magnesium stearate; Hypromellose; Carbomer 934; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Magnesium stearate; Carbomer 934; Cellulose, microcrystalline; Hypromelloses; Sodium starch glycolate type a potato
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Magnesium stearate; Aluminum oxide; Carbomer homopolymer type b (allyl pentaerythritol crosslinked); Hypromellose, unspecified; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company A-S Medication Solutions; Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Magnesium stearate; Aluminum oxide; Carbomer homopolymer type b (allyl pentaerythritol crosslinked); Hypromellose, unspecified; Microcrystalline cellulose
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Magnesium stearate; Aluminum oxide; Carbomer homopolymer type b (allyl pentaerythritol crosslinked); Cellulose, microcrystalline; Hypromelloses; Sodium starch glycolate type a potato
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Reckitt Benckiser; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Magnesium stearate; Carbomer homopolymer type b (allyl pentaerythritol crosslinked); Cellulose, microcrystalline; Hypromelloses; Sodium starch glycolate type a potato
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Magnesium stearate; Aluminum oxide; Carbomer homopolymer type b; Cellulose, microcrystalline; Hypromelloses
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company Dispensing Solution
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Magnesium stearate; Carbomer homopolymer type b; Cellulose, microcrystalline; Hypromelloses; Sodium starch glycolate type a potato
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Magnesium stearate; Aluminum oxide; Carbomer homopolymer type b (allyl pentaerythritol crosslinked); Cellulose, microcrystalline; Hypromelloses
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company American Health Packaging; Atlantic Biologicals; Avera McKennan Hospital; Cardinal Health; DirectRX
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Zinc stearate; Silicon dioxide; Copovidone k25-31; Hydroxyethyl cellulose (100 mpa.s at 2%)
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company NCS HealthCare of KY, Inc dba Vangard Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Zinc stearate; Silicon dioxide; Copovidone k25-31
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company 7-Eleven; American Sales Company; Amerisource Bergen; CVS Pharmacy; Cardinal Health; Dolgencorp; H E B; Hy-Vee; Kroger Company; Lake Eire Medical & Surgical Supply DBA Quality Care Products; McKesson; Meijer; Perrigo New York; Publix Super Markets; Rite Aid; Rugby Laboratories; SuperValu; Target Corporation; Topco Associates; Wal-Mart Stores; Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Carbomer homopolymer type b (allyl pentaerythritol or allyl sucrose crosslinked); Hypromellose, unspecified; Microcrystalline cellulose
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company Kroger Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Carbomer homopolymer type b (allyl pentaerythritol or allyl sucrose crosslinked); Hypromellose, unspecified; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form 12 HR Extended Release Oral Tablet
                   Company Amerisource Bergen; Chain Drug Marketing Association; McKesson; Ohm Laboratories; Wal-Mart Stores; Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
References
1 FDA label for approved guaifenesin from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
5 Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.
6 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
7 Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose. ACS Med Chem Lett. 2018 May 10; 9(7):657-661.
8 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.
9 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
10 PubChem BioAssay data set.
11 Synthesis and evaluation of novel 4-[(3H,3aH,6aH)-3-phenyl)-4,6-dioxo-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazol-5(3H,6H,6aH)-yl]benzoic acid derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents. Bioorg Med Chem. 2012 Jan 1; 20(1):521-30.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.