General Information of DFM (ID: F15763)
Name	Olaparib 50 mg capsule
Company	AstraZeneca
Active Pharmaceutical Ingredient (API)	Olaparib		API Info click to show the detail info of this API
	Ovarian cancer		ICD-11: 2C73	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0A1CS	DIG Info	Ammonia	Alkalizing agent
	E01VDF	DIG Info	Butyl alcohol	Flavoring agent ...
	E02FBG	DIG Info	Ferrosoferric oxide	Colorant
	E0N2PK	DIG Info	Isopropyl alcohol	Antimicrobial preservative ...
	E0I6EI	DIG Info	Potassium acetate	Film/membrane-forming agent
	E0M1JK	DIG Info	Propylene glycol	Antimicrobial preservative ...
	E05BSD	DIG Info	Titanium dioxide	Coating agent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
G-protein coupled receptor (GPCR)
DBT Name: Free fatty acid receptor 3 (FFAR3)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Potassium acetate
Biological Activity	EC50 = 5000 nM (estimated based on the structural similarity with CHEMBL500826 )					[1]
Structural Similarity	Tanimoto coefficient = 0.789473684
Tested Species	Rattus norvegicus (Rat)
UniProt ID	FFAR3_RAT
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Propylene glycol
Biological Activity	Inhibition ratio < 20 % (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Cell line (CELL)
DBT Name: Lymphoma P388/ADR cells (P388/ADR)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Isopropyl alcohol
Biological Activity	IC50 = 0.22 uM (estimated based on the structural similarity with CHEMBL545 )					[3]
Structural Similarity	Tanimoto coefficient = 0.789473684
Tested Species	Mus musculus (Mouse)
Cellosaurus ID	CVCL_IZ75

References
1	WO patent application no. 2001061359A2, NOVEL ASSAY.
2	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
3	Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11; 47(6):1413-22.

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