General Information of DFM (ID: F18869)
Name	Ranitidine 75 mg tablet
Company	Allegiant Health
Active Pharmaceutical Ingredient (API)	Ranitidine		API Info click to show the detail info of this API
	Gastric ulcer		ICD-11: DA60	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E09YYN	DIG Info	Eisenoxyd	Colorant
	E0M0IE	DIG Info	Ferric hydroxide oxide yellow	Colorant
	E01UTP	DIG Info	Magnesium stearate	lubricant
	E01UTV	DIG Info	Silicon dioxide	Anticaking agent ...
	E05BSD	DIG Info	Titanium dioxide	Coating agent ...
	E08VAJ	DIG Info	Vanillin	Flavoring agent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Aldehyde dehydrogenase 5A1 (ALDH5A1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Vanillin
Biological Activity	IC50 = 15600 nM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	SSDH_HUMAN
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Magnesium stearate
Biological Activity	Protein expression downregulation (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Silicon dioxide
Biological Activity	Protein expression downregulation (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Transferase (TFase)
DBT Name: GABA transaminase (ABAT)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Vanillin
Biological Activity	IC50 = 17100 nM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	GABT_HUMAN
Hydrolase (HDase)
DBT Name: Pancreatic lipase (PTL)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Vanillin
Biological Activity	IC50 = 74400 nM (tested by experiment)					[3]
Tested Species	Sus scrofa (Pig)
UniProt ID	LIPP_PIG
Nuclear receptor (NR)
DBT Name: Androgen receptor (AR)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Vanillin
Biological Activity	IC50 > 426579.52 nM (tested by experiment)					[4]
Tested Species	Rattus norvegicus (Rat)
UniProt ID	ANDR_RAT

References
1	Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb; 16(3):592-5.
2	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
3	Enhancement of pancreatic lipase inhibitory activity of curcumin by radiolytic transformation. Bioorg Med Chem Lett. 2011 Mar 1; 21(5):1512-4.
4	Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. J Med Chem. 2005 Sep 8; 48(18):5666-74.

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