Details of the Drug Formulation (DFM)
| General Information of DFM (ID: F20382) | |||||
|---|---|---|---|---|---|
| Name |
Spironolactone 100 mg tablet
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| Company |
A-S Medication Solutions
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| Active Pharmaceutical Ingredient (API) | Spironolactone |
API Info
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| Congestive heart failure | ICD-11: BD10 | Approved | |||
| Drug Inactive Ingredient (DIGs) | |||||
| DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
| E0DY5F | DIG Info | Calcium sulfate dihydrate | Desiccant ... | ||
| E03SQI | DIG Info | Carmellose sodium | Disintegrant | ||
| E09YYN | DIG Info | Eisenoxyd | Colorant | ||
| E0M0IE | DIG Info | Ferric hydroxide oxide yellow | Colorant | ||
| E02FBG | DIG Info | Ferrosoferric oxide | Colorant | ||
| E01UTP | DIG Info | Magnesium stearate | lubricant | ||
| E09IPB | DIG Info | Polyethylene glycol 3350 | Coating agent ... | ||
| E0QY1F | DIG Info | Talc | Anticaking agent ... | ||
| E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
| Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
|---|---|---|---|---|---|---|
| Oxidoreductase (ORase) | ||||||
| DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Magnesium stearate | |||||
| Biological Activity | Protein expression downregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Carmellose sodium | |||||
| Biological Activity | Protein expression upregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Carmellose sodium | |||||
| Biological Activity | Protein expression upregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| Experiment (4) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Polyethylene glycol 3350 | |||||
| Biological Activity | Protein expression upregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| Primary active transporter (PAT) | ||||||
| DBT Name: Multidrug resistance protein 1 (ABCB1) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
click to show the detail info of this DBT
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Polyethylene glycol 3350 | |||||
| Biological Activity | Protein expression downregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | MDR1_HUMAN | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12. | ||||
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