Details of the Drug Formulation (DFM)
General Information of DFM (ID: F20566) | |||||
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Name |
Sumatriptan 50 mg tablet
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Company |
Hikma Pharmaceutical
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Active Pharmaceutical Ingredient (API) | Sumatriptan | API Info click to show the detail info of this API | |||
Migraine | ICD-11: 8A80 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E03SQI | DIG Info | Carmellose sodium | Disintegrant | ||
E01UTP | DIG Info | Magnesium stearate | lubricant | ||
E09IPB | DIG Info | Polyethylene glycol 3350 | Coating agent ... | ||
E0V3ER | DIG Info | Polyvinyl alcohol | Coating agent ... | ||
E0G1YW | DIG Info | Sodium bicarbonate | Alkalizing agent ... | ||
E0QY1F | DIG Info | Talc | Anticaking agent ... | ||
E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
E0FU1S | DIG Info | Vinylpyrrolidone | Binding agent ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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Oxidoreductase (ORase) | ||||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Magnesium stearate | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Carmellose sodium | |||||
Biological Activity | Protein expression upregulation (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Carmellose sodium | |||||
Biological Activity | Protein expression upregulation (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (4) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 3350 | |||||
Biological Activity | Protein expression upregulation (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
DBT Name: Cytochrome P450 2E1 (CYP2E1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyvinyl alcohol | |||||
Biological Activity | IC50 = 548.9 uM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2E1_HUMAN | |||||
DBT Name: Debrisoquine 4-hydroxylase (CYP2D6) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyvinyl alcohol | |||||
Biological Activity | EC50 = 354.8 uM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2D6_HUMAN | |||||
Primary active transporter (PAT) | ||||||
DBT Name: Multidrug resistance protein 1 (ABCB1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 3350 | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN | |||||
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