Details of the Drug Formulation (DFM)

General Information of DFM (ID: F23263)
Name
Prednicarbate 0.1% cream
Company
Oceanside Pharmaceuticals
Active Pharmaceutical Ingredient (API) Prednicarbate API Info click to show the detail info of this API
Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E09FCQ DIG Info Aluminum stearate Emollient ...
E06DEM DIG Info Cetostearyl alcohol Emollient ...
E0FY2S DIG Info Edetate disodium Complexing agent
E07RWU DIG Info Isopropyl myristate Emollient ...
E0D6JV DIG Info Lactic acid Acidulant
E01UTP DIG Info Magnesium stearate lubricant
E0H2SC DIG Info Water Solvent
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Oxidoreductase (ORase)
            DBT Name: Albendazole monooxygenase (CYP3A4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Magnesium stearate
                    Biological Activity Protein expression downregulation (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP3A4_HUMAN
      Cell line (CELL)
            DBT Name: Fetal lung MRC5 cells (MRC5) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Lactic acid
                    Biological Activity IC50 = 23930 nM (estimated based on the structural similarity with CHEMBL330546 ) [2]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0440
References
1 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
2 Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification. Eur J Med Chem. 2017 Sep 29; 138:644-660.

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