General Information of DFM (ID: F23642)
Name	Betamethasone 0.05% ointment
Company	Preferred Pharmaceuticals
Active Pharmaceutical Ingredient (API)	Betamethasone		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0IS1Z	DIG Info	Chlorocresol	Antimicrobial preservative
	E0ZJ4T	DIG Info	Cyclomethicone	Emollient ...
	E0M1JK	DIG Info	Propylene glycol	Antimicrobial preservative ...
	E0L2PN	DIG Info	Sodium hydroxide	Alkalizing agent
	E0G5FT	DIG Info	Sorbitan tristearate	Dispersing agent ...
	E0H2SC	DIG Info	Water	Solvent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
G-protein coupled receptor (GPCR)
DBT Name: Serotonin receptor 2B (5HT2B)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Chlorocresol
Biological Activity	IC50 = 1856 nM (estimated based on the structural similarity with CHEMBL398440 )					[1]
Structural Similarity	Tanimoto coefficient = 0.928571429
Tested Species	Homo sapiens (Human)
UniProt ID	5HT2B_HUMAN
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Propylene glycol
Biological Activity	Inhibition ratio < 20 % (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN

References
1	DrugMatrix in vitro pharmacology data.
2	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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