General Information of DFM (ID: F23652)
Name	Brimonidine Tartrate 0.025% solution
Company	Bausch & Lomb orporated
Active Pharmaceutical Ingredient (API)	Brimonidine tartrate		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0X1KL	DIG Info	Benzalkonium chloride	Antimicrobial preservative ...
	E0Q4LO	DIG Info	Boric acid	Antimicrobial preservative ...
	E0N0NF	DIG Info	Calcium chloride	Antimicrobial preservative ...
	E06WYP	DIG Info	Glycerin	Antimicrobial preservative ...
	E02GBG	DIG Info	Potassium chloride	Tonicity agent
	E00FOE	DIG Info	Sodium borate	Alkalizing agent ...
	E0T4TW	DIG Info	Sodium chloride	Diluent ...
	E0H2SC	DIG Info	Water	Solvent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Monoamine oxidase (MAO)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Benzalkonium chloride
Biological Activity	IC50 = 8200 nM (estimated based on the structural similarity with CHEMBL8695 )					[1]
Structural Similarity	Tanimoto coefficient = 0.97260274
Tested Species	Rattus norvegicus (Rat)
UniProt ID	AOFA_RAT ; AOFB_RAT
Lyase/isomerase/ligase (L/I/G)
DBT Name: Carbonic anhydrase IV (CA4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Potassium chloride
Biological Activity	Ki = 90000 nM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH4_HUMAN
Potential-driven transporter (PDT)
DBT Name: Solute carrier SLCO2B1 (OATPB)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Benzalkonium chloride
Biological Activity	Inhibition ratio = 77.4 % (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Benzalkonium chloride
Biological Activity	Ki = 62.1 uM (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN

References
1	Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes. J Med Chem. 1983 Jul; 26(7):1036-42.
2	Characterization and anions inhibition studies of an -carbonic anhydrase from the teleost fish Dicentrarchus labrax. Bioorg Med Chem. 2011 Jan 15; 19(2):744-8.
3	Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.

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