General Information of DFM (ID: F23766)
Name	Halobetasol Propionate 0.05% ointment
Company	Cosette Pharmaceuticals
Active Pharmaceutical Ingredient (API)	Halobetasol propionate		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E09FCQ	DIG Info	Aluminum stearate	Emollient ...
	E0VT1H	DIG Info	Monostearyl citrate	Emollient
	E0M1JK	DIG Info	Propylene glycol	Antimicrobial preservative ...
	E0B0EX	DIG Info	Sorbitan sesquioleate	Dispersing agent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Propylene glycol
Biological Activity	Inhibition ratio < 20 % (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Transferase (TFase)
DBT Name: Squalene synthase (FDFT1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Monostearyl citrate
Biological Activity	IC50 = 9000 nM (estimated based on the structural similarity with CHEMBL78764 )					[2]
Structural Similarity	Tanimoto coefficient = 0.835820896
Tested Species	Rattus norvegicus (Rat)
UniProt ID	FDFT_RAT
Lyase/isomerase/ligase (L/I/G)
DBT Name: Hsp60-Hsp10 complex (HSPD1-HSPE1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Monostearyl citrate
Biological Activity	IC50 = 4000 nM (estimated based on the structural similarity with CHEMBL78764 )					[3]
Structural Similarity	Tanimoto coefficient = 0.835820896
Tested Species	Homo sapiens (Human)
UniProt ID	CH60_HUMAN ; CH10_HUMAN

References
1	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
2	Isolation, structure determination and squalene synthase activity of L-731,120 and L-731,128, alkyl citrate analogs of zaragozic acids A and B. Bioorg Med Chem Lett. (1995) 5:2403-2408.
3	HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. Bioorg Med Chem Lett. 2019 May 1; 29(9):1106-1112.

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