General Information of DFM (ID: F23917)
Name	Terconazole 80 mg Vaginal Suppository
Company	Janssen Pharms
Active Pharmaceutical Ingredient (API)	Terconazole		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0QV6C	DIG Info	Butylhydroxyanisole	Antimicrobial preservative ...
	E0C3AX	DIG Info	Lauric acid	Antifoaming agent ...
	E0X2OX	DIG Info	Medium-chain triglyceride	Emollient ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
G-protein coupled receptor (GPCR)
DBT Name: Free fatty acid receptor 1 (FFAR1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Lauric acid
Biological Activity	EC50 = 758.58 nM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	FFAR1_HUMAN
DBT Name: Free fatty acid receptor 4 (FFAR4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Lauric acid
Biological Activity	EC50 = 7585.78 nM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	FFAR4_HUMAN
DBT Name: GPCR84 receptor (GPR84)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Lauric acid
Biological Activity	Ki = 2170 nM (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	GPR84_HUMAN
DBT Name: Muscarinic receptor M1 (ACM1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Butylhydroxyanisole
Biological Activity	IC50 = 19 uM (tested by experiment)					[4]
Tested Species	Homo sapiens (Human)
UniProt ID	ACM1_HUMAN
DBT Name: Alpha-1A adrenoceptor (ADA1A)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Butylhydroxyanisole
Biological Activity	IC50 = 19 uM (tested by experiment)					[4]
Tested Species	Homo sapiens (Human)
UniProt ID	ADA1A_HUMAN
Oxidoreductase (ORase)
DBT Name: Prostaglandin G/H synthase 2 (COX-2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Butylhydroxyanisole
Biological Activity	IC50 = 2.6 uM (tested by experiment)					[4]
Tested Species	Homo sapiens (Human)
UniProt ID	PGH2_HUMAN
Nuclear receptor (NR)
DBT Name: PPAR-alpha (PPARA)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Lauric acid
Biological Activity	IC50 = 30000 nM (tested by experiment)					[5]
Tested Species	Homo sapiens (Human)
UniProt ID	PPARA_HUMAN
DBT Name: PPAR-delta (PPARD)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Lauric acid
Biological Activity	IC50 = 30000 nM (tested by experiment)					[5]
Tested Species	Homo sapiens (Human)
UniProt ID	PPARD_HUMAN
DBT Name: PPAR-gamma (PPARG)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Lauric acid
Biological Activity	IC50 = 30000 nM (tested by experiment)					[5]
Tested Species	Homo sapiens (Human)
UniProt ID	PPARG_HUMAN
DBT Name: Progesterone receptor (PGR)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Butylhydroxyanisole
Biological Activity	IC50 = 29 uM (tested by experiment)					[4]
Tested Species	Homo sapiens (Human)
UniProt ID	PRGR_HUMAN
Cell line (CELL)
DBT Name: Colon cancer Caco-2 cells (Caco-2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Medium-chain triglyceride
Biological Activity	Inhibition ratio > 36 % (tested by experiment)					[6]
Tested Species	Homo sapiens (Human)

References
1	Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer. J Med Chem. 2016 May 26; 59(10):4849-58.
2	Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84. Med Chem Comm. 2017; 8:1360-1365.
3	An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights. J Med Chem. 2020 Mar 12; 63(5):2391-2410.
4	The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
5	Molecular properties of fatty acids related to PPAR binding and metabolic diseases. Med Chem Res (2013) 22:3126-3133.
6	Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.

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