General Information of DFM (ID: F24024)
Name	Bendamustine Hydrochloride 25mg/vial powder
Company	Cephalon
Active Pharmaceutical Ingredient (API)	Bendamustine hydrochloride		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0U3EK	DIG Info	Acetdimethylamide	Solvent
	E0M1JK	DIG Info	Propylene glycol	Antimicrobial preservative ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Propylene glycol
Biological Activity	Inhibition ratio < 20 % (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Cell line (CELL)
DBT Name: Glioblastoma A-172 cells (A-172)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Acetdimethylamide
Biological Activity	IC50 = 37000 nM (estimated based on the structural similarity with CHEMBL316041 )					[2]
Structural Similarity	Tanimoto coefficient = 0.793103448
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0131
DBT Name: Lung cancer A-427 cells (A-427)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Acetdimethylamide
Biological Activity	IC50 = 11000 nM (estimated based on the structural similarity with CHEMBL316041 )					[2]
Structural Similarity	Tanimoto coefficient = 0.793103448
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_1055
DBT Name: Breast cancer DOD-1 cells (DOD-1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Acetdimethylamide
Biological Activity	IC50 = 60000 nM (estimated based on the structural similarity with CHEMBL316041 )					[2]
Structural Similarity	Tanimoto coefficient = 0.793103448
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_1183
DBT Name: Ovarian cancer ADR-RES cells (NCI/ADR-RES)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Acetdimethylamide
Biological Activity	IC50 = 40000 nM (estimated based on the structural similarity with CHEMBL316041 )					[2]
Structural Similarity	Tanimoto coefficient = 0.793103448
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_1452
DBT Name: Lung cancer NCI-H358 cells (NCI-H358)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Acetdimethylamide
Biological Activity	IC50 = 100000 nM (estimated based on the structural similarity with CHEMBL316041 )					[2]
Structural Similarity	Tanimoto coefficient = 0.793103448
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_1559
DBT Name: Ovarian cancer OVCAR-3 cells (OVCAR-3)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Acetdimethylamide
Biological Activity	IC50 = 55000 nM (estimated based on the structural similarity with CHEMBL316041 )					[2]
Structural Similarity	Tanimoto coefficient = 0.793103448
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0465
DBT Name: Melanoma RPMI-7951 cells (RPMI-7951)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Acetdimethylamide
Biological Activity	IC50 = 60000 nM (estimated based on the structural similarity with CHEMBL316041 )					[2]
Structural Similarity	Tanimoto coefficient = 0.793103448
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_1666
DBT Name: Melanoma SK-MEL-5 cells (SK-MEL-5)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Acetdimethylamide
Biological Activity	IC50 = 37000 nM (estimated based on the structural similarity with CHEMBL316041 )					[2]
Structural Similarity	Tanimoto coefficient = 0.793103448
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0527
DBT Name: Astrocytoma U251 cells (U251)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Acetdimethylamide
Biological Activity	IC50 = 42000 nM (estimated based on the structural similarity with CHEMBL316041 )					[2]
Structural Similarity	Tanimoto coefficient = 0.793103448
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0021

References
1	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
2	1,3-Dialkyl-3-acyltriazenes, a novel class of antineoplastic alkylating agents. J Med Chem. 1990 Sep; 33(9):2579-83.

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