Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E06TQE)
DIG Name
Polyethylene glycol 20000
DIG Function
Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 01 Infectious/parasitic disease Click to Show/Hide
Itraconazole
 API Info
Blastomycosis [ICD-11: 1F22]
 [1]
       ICD Disease Classification 05 Endocrine/nutritional/metabolic disease Click to Show/Hide
Fenofibrate
 API Info
Hypertriglyceridaemia [ICD-11: 5C80]
 [2]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Primary active transporter (PAT)
            DBT Name: Multidrug resistance protein 1 (ABCB1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Inhibition ratio = 72 % (tested by experiment) [3]
                    Tested Species Homo sapiens (Human)
                    UniProt ID MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
References
1 FDA label for approved itraconazole from the official website of the U.S. Food and Drug Administration.
2 FDA label for approved fenofibrate from the official website of the U.S. Food and Drug Administration.
3 Modulation of intestinal P-glycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies. Int J Pharm. 2006 Apr 26;313(1-2):49-56.

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