Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0Q8ZK)
DIG Name	Calcium hydrogenphosphate
Synonyms	Click to Show/Hide the Synonyms of This DIG 7757-93-9; CALCIUM HYDROGEN PHOSPHATE; calcium hydrogenphosphate; Calcium phosphate, dibasic; Calcium phosphate dibasic; Dicalcium phosphate; Phosphoric acid, calcium salt (1:1); Dibasic calcium phosphate; Monocalcium acid phosphate; secondary Calcium phosphate; Calcium phosphate (1:1); Dicalcium Phosphate Anhydrous; UNII-L11K75P92J; CALCIUMPHOSPHATE,DIBASIC; Calcium phosphate dibasic anhydrous; MFCD00010909; CHEBI:32596; L11K75P92J; Biofos; Fujicalin S; Dicafos AN; Anhydrous Emcompress; Ipifosc 20; A-Tab; Calcium acid phosphate; Calcium hydrogen orthophosphate; Dicalcium orthophosphate; Calcium dibasic phosphate; Calcium secondary phosphate; Calcium phosphate (CaHPO4); Calcium monohydrogen phosphate; Monohydrogen calcium phosphate; CCRIS 1337; HSDB 992; CaHPO4; Calcium phosphate, dibasic [JAN]; Calcium phosphate, dibasic, 97%, pure, anhydrous; EINECS 231-826-1; 7789-77-7 (.2H2O); Calcium phosphate, dibasic, 98+%, for analysis, anhydrous; Calcium hydrogenorthophosphate; Calcium phosphate, dibasic, dental grade; Anhydrous dibasic calcium phosphate; Calstar (TN); Calcium monohydrogen phosphate anhydrous; Ca.HPO4; Calcium phosphate,dibasic; EC 231-826-1; calcium monohydrogenphosphate; Dicalcium phosphate, anhydrous; CHEMBL2107567; DTXSID20872529; PHOSPHORIC ACID CALCIUM SALT; Calcium phosphate dibasic, anhydrous; 8202AF; Calcium hydrogen phosphate, anhydrous; Calcium phosphate, dibasic, anhydrous; AKOS015965054; Calcium Hydrogenorthophosphate Anhydrous; 7557-93-9; Calcium hydrogenorthophosphate, with a fluorine content of less than 0,005 per cent by weight on the dry anhydrous product; Calcium phosphate, dibasic (99.95%-Ca); Calcium phosphate dibasic, 98.0-105.0%; Dibasic calcium phosphate, anhydrous (JAN); Calcium phosphate dibasic, puriss., 98.0%; FT-0623397; D03302; Calcium Phosphate dibasic anhydrous, USP FCC PE; Calcium phosphate dibasic, USP, 98.0-103.0%; Q414619; Calcium phosphate dibasic, anhydrous, EP, USP grade; D-Glucopyranosiduronicacid, 1-(2,4-dichlorophenyl)ethyl; Dibasic Calcium Phosphate, meets USP testing specifications; UNII-97Z1WI3NDX component FUFJGUQYACFECW-UHFFFAOYSA-L; Calcium phosphate dibasic, puriss. p.a., anhydrous, >98.5% (KT)
DIG Function	Diluent
PubChem CID	24441
Formula	CaHO4P
Canonical SMILES	OP(=O)([O-])[O-].[Ca+2]
InChI	1S/Ca.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+2;/p-2
InChIKey	FUFJGUQYACFECW-UHFFFAOYSA-L
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=24441"></iframe>
Structure	3D MOL is not available		2D MOL
Physicochemical Properties	Molecular Weight	136.06	Topological Polar Surface Area	83.4
	XlogP	N.A.	Complexity	46.5
	Heavy Atom Count	6	Rotatable Bond Count	0
	Hydrogen Bond Donor Count	1	Hydrogen Bond Acceptor Count	4

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Fluconazole	API Info	Candidiasis [ICD-11: 1F23]		[1]
Azithromycin	API Info	Congenital syphilis [ICD-11: 1A60]		[2]
Maraviroc	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[3]
Ciprofloxacin	API Info	Endocarditis [ICD-11: 1B12]		[4]
Griseofulvin	API Info	Dermatophytosis [ICD-11: 1F28]		[5]
Raltegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[6]
Chloroquine	API Info	Malaria [ICD-11: 1F40]		[7]
Ritonavir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[8]
Hydroxychloroquine	API Info	Malaria [ICD-11: 1F40]		[9]
Pyrantel	API Info	Hookworm disease [ICD-11: 1F68]		[10]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Nystatin	API Info	Acute lymphoblastic leukemia [ICD-11: 2B33]		[11]
Venetoclax	API Info	Chronic lymphocytic leukaemia [ICD-11: 2A82]		[12]
Crizotinib	API Info	Lung cancer [ICD-11: 2C25]		[13]
Megestrol acetate	API Info	Breast cancer [ICD-11: 2C60]		[14]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Levothroid	API Info	Hypothyroidism [ICD-11: 5A00]		[15]
Pravastatin	API Info	Dyslipidaemia [ICD-11: 5C81]		[16]
Glyburide	API Info	Diabetes mellitus [ICD-11: 5A10]		[17]
Rosuvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[18]
Repaglinide	API Info	Diabetes mellitus [ICD-11: 5A10]		[19]
Phendimetrazine	API Info	Obesity [ICD-11: 5B81]		[20]
Sitagliptin	API Info	Diabetes mellitus [ICD-11: 5A10]		[21]
Fludrocortisone	API Info	Hyponatraemia [ICD-11: 5C72]		[22]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Sertraline	API Info	Major depressive disorder [ICD-11: 6A70]		[23]
Hydroxyzine	API Info	Anxiety disorder [ICD-11: 6B00]		[24]
Paroxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[25]
Quetiapine	API Info	Schizophrenia [ICD-11: 6A20]		[26]
Cyclobenzaprine	API Info	Major depressive disorder [ICD-11: 6A70]		[27]
Imipramine	API Info	Major depressive disorder [ICD-11: 6A70]		[28]
Trazodone	API Info	Major depressive disorder [ICD-11: 6A70]		[29]
Protriptyline	API Info	Major depressive disorder [ICD-11: 6A70]		[30]
Amoxapine	API Info	Major depressive disorder [ICD-11: 6A70]		[31]
Varenicline	API Info	Nicotine dependence [ICD-11: 6C4A]		[32]
ICD Disease Classification 07		Sleep-wake disorder	Click to Show/Hide
Zolpidem	API Info	Insomnia [ICD-11: 7A00]		[33]
Eszopiclone	API Info	Insomnia [ICD-11: 7A00]		[34]
Modafinil	API Info	Narcolepsy [ICD-11: 7A20]		[35]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Acetaminophen	API Info	Anaesthesia [ICD-11: 8E22]		[36]
Levetiracetam	API Info	Focal seizure [ICD-11: 8A68]		[37]
Rizatriptan	API Info	Migraine [ICD-11: 8A80]		[38]
Meperidine	API Info	Anaesthesia [ICD-11: 8E22]		[39]
Sumatriptan	API Info	Migraine [ICD-11: 8A80]		[40]
Tolcapone	API Info	Parkinsonism [ICD-11: 8A00]		[41]
Benztropine	API Info	Parkinsonism [ICD-11: 8A00]		[42]
Trihexyphenidyl	API Info	Parkinsonism [ICD-11: 8A00]		[43]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Diphenhydramine	API Info	Meniere disease [ICD-11: AB31]		[44]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Lisinopril	API Info	Essential hypertension [ICD-11: BA00]		[45]
Aspirin	API Info	Myocardial infarction [ICD-11: BA41]		[46]
Clonidine	API Info	Essential hypertension [ICD-11: BA00]		[47]
Caffeine	API Info	Orthostatic hypotension [ICD-11: BA21]		[48]
Amlodipine	API Info	Angina pectoris [ICD-11: BA40]		[49]
Irbesartan	API Info	Essential hypertension [ICD-11: BA00]		[50]
Bisoprolol	API Info	Essential hypertension [ICD-11: BA00]		[51]
Bosentan	API Info	Pulmonary hypertension [ICD-11: BB01]		[52]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Chlorpheniramine	API Info	Allergic rhinitis [ICD-11: CA08]		[53]
Promethazine	API Info	Allergic rhinitis [ICD-11: CA08]		[54]
Glycopyrrolate	API Info	Chronic obstructive pulmonary disease [ICD-11: CA22]		[55]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Omeprazole	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[56]
Meclizine	API Info	Functional nausea/vomiting [ICD-11: DD90]		[57]
Esomeprazole	API Info	Duodenal ulcer [ICD-11: DA63]		[58]
Loperamide	API Info	Irritable bowel syndrome [ICD-11: DD91]		[59]
Dicyclomine	API Info	Irritable bowel syndrome [ICD-11: DD91]		[60]
Metoclopramide	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[61]
Dimenhydrinate	API Info	Functional nausea/vomiting [ICD-11: DD90]		[62]
ICD Disease Classification 14		Skin disease	Click to Show/Hide
Hydrochlorothiazide	API Info	Luid retention [ICD-11: EF02]		[63]
Pseudoephedrine	API Info	Erythema multiforme [ICD-11: EB12]		[64]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Etodolac	API Info	Rheumatoid arthritis [ICD-11: FA20]		[65]
Phenylephrine	API Info	Juvenile rheumatoid arthritis [ICD-11: FA24]		[66]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Oxybutynin	API Info	Overactive bladder [ICD-11: GC50]		[67]
Tolterodine	API Info	Overactive bladder [ICD-11: GC50]		[68]
Methenamine	API Info	Urinary tract infection [ICD-11: GC08]		[69]
Darifenacin	API Info	Overactive bladder [ICD-11: GC50]		[70]
Alfuzosin	API Info	Prostatic hyperplasia [ICD-11: GA90]		[71]
ICD Disease Classification 17		Sexual health-related condition	Click to Show/Hide
Sildenafil	API Info	Erectile dysfunction [ICD-11: HA01]		[72]
ICD Disease Classification 18		Pregnancy/childbirth/puerperium condition	Click to Show/Hide
Doxylamine	API Info	Morning sickness [ICD-11: JA60]		[73]
ICD Disease Classification 20		Developmental anomaly	Click to Show/Hide
Estradiol	API Info	Turner syndrome [ICD-11: LD50]		[74]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Protein expression downregulation (tested by experiment)		[75]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN

References
1	FDA label for approved fluconazole from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved azithromycin from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved maraviroc from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved ciprofloxacin from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved griseofulvin from the official website of the U.S. Food and Drug Administration.
6	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
7	FDA label for approved chloroquine from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved ritonavir from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved hydroxychloroquine from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved pyrantel from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved nystatin from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved venetoclax from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved crizotinib from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved megestrol acetate from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved levothroid from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved pravastatin from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved glyburide from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved rosuvastatin from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved repaglinide from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved phendimetrazine from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved sitagliptin from the official website of the U.S. Food and Drug Administration.
22	Management of adrenal insufficiency in different clinical settings. Expert Opin Pharmacother. 2005 Nov;6(14):2407-17.
23	FDA label for approved sertraline from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved hydroxyzine from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved paroxetine from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved quetiapine from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved cyclobenzaprine from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved imipramine from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved trazodone from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved protriptyline from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved amoxapine from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved varenicline from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved zolpidem from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved eszopiclone from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved modafinil from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved levetiracetam from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved rizatriptan from the official website of the U.S. Food and Drug Administration.
39	FDA label for approved meperidine from the official website of the U.S. Food and Drug Administration.
40	FDA label for approved sumatriptan from the official website of the U.S. Food and Drug Administration.
41	FDA label for approved tolcapone from the official website of the U.S. Food and Drug Administration.
42	FDA label for approved benztropine from the official website of the U.S. Food and Drug Administration.
43	FDA label for approved trihexyphenidyl from the official website of the U.S. Food and Drug Administration.
44	FDA label for approved diphenhydramine from the official website of the U.S. Food and Drug Administration.
45	FDA label for approved lisinopril from the official website of the U.S. Food and Drug Administration.
46	FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
47	FDA label for approved clonidine from the official website of the U.S. Food and Drug Administration.
48	FDA label for approved caffeine from the official website of the U.S. Food and Drug Administration.
49	FDA label for approved amlodipine from the official website of the U.S. Food and Drug Administration.
50	FDA label for approved irbesartan from the official website of the U.S. Food and Drug Administration.
51	FDA label for approved bisoprolol from the official website of the U.S. Food and Drug Administration.
52	FDA label for approved bosentan from the official website of the U.S. Food and Drug Administration.
53	FDA label for approved chlorpheniramine from the official website of the U.S. Food and Drug Administration.
54	FDA label for approved promethazine from the official website of the U.S. Food and Drug Administration.
55	FDA label for approved glycopyrrolate from the official website of the U.S. Food and Drug Administration.
56	FDA label for approved omeprazole from the official website of the U.S. Food and Drug Administration.
57	FDA label for approved meclizine from the official website of the U.S. Food and Drug Administration.
58	FDA label for approved esomeprazole from the official website of the U.S. Food and Drug Administration.
59	FDA label for approved loperamide from the official website of the U.S. Food and Drug Administration.
60	FDA label for approved dicyclomine from the official website of the U.S. Food and Drug Administration.
61	FDA label for approved metoclopramide from the official website of the U.S. Food and Drug Administration.
62	FDA label for approved dimenhydrinate from the official website of the U.S. Food and Drug Administration.
63	FDA label for approved hydrochlorothiazide from the official website of the U.S. Food and Drug Administration.
64	A study of sustained action pseudoephedrine in allergic rhinitis. Ann Allergy. 1982 Feb;48(2):87-92.
65	FDA label for approved etodolac from the official website of the U.S. Food and Drug Administration.
66	FDA label for approved phenylephrine from the official website of the U.S. Food and Drug Administration.
67	FDA label for approved oxybutynin from the official website of the U.S. Food and Drug Administration.
68	FDA label for approved tolterodine from the official website of the U.S. Food and Drug Administration.
69	FDA label for approved methenamine from the official website of the U.S. Food and Drug Administration.
70	FDA label for approved darifenacin from the official website of the U.S. Food and Drug Administration.
71	FDA label for approved alfuzosin from the official website of the U.S. Food and Drug Administration.
72	FDA label for approved sildenafil from the official website of the U.S. Food and Drug Administration.
73	FDA label for approved doxylamine from the official website of the U.S. Food and Drug Administration.
74	FDA label for approved estradiol from the official website of the U.S. Food and Drug Administration.
75	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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