Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00186)
Name
Dexbrompheniramine
Synonyms    Click to Show/Hide the Synonyms of This API
Dexbrompheniramine; D-Brompheniramine; 132-21-8; Dexbromfeniramina; Dexbrompheniraminum; (S)-brompheniramine; (+)-brompheniraminum; (S)-(+)-brompheniramine; Disomer; UNII-75T64B71RP; (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine; CHEBI:59269; 75T64B71RP; Dexbrompheniramine [INN:BAN]; Dexbromfeniramina [INN-Spanish]; Dexbrompheniraminum [INN-Latin]; Brompheniramine d-; NCGC00162100-02; EINECS 205-053-5; Desbrofeniramina; (+)-Parabromdylamine; ZINC96; Lopac0_000232; SCHEMBL29345; GTPL7588; (+)-(3-p-Bromphenyl-3-pyrid-2'-ylpropyl)dimethylamin; CHEMBL1201287; DTXSID8022905; (+)-N,N-Dimethyl-(3-(4-bromphenyl)-3-(2-pyridyl)propyl)amin; (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine; PDSP1_000134; PDSP1_000135; PDSP2_000133; PDSP2_000134; AKOS015969654; CCG-204327; DB00405; SDCCGSBI-0050220.P002; NCGC00162100-01; NCGC00162100-03; NCGC00162100-05; AB00698453-08; Q5268318; (R)-3-(4-Bromophenyl)-3-(2-pyridyl)propyldimethylamine; UNII-H57G17P2FN component ZDIGNSYAACHWNL-HNNXBMFYSA-N; [(3S)-3-(4-bromophenyl)-3-(pyridin-2-yl)propyl]dimethylamine; 3-(4-bromophenyl)- N,N-dimethyl- 3-pyridin-2-yl-propan-1-amine; 3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine #; (S)-3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine; 2-Pyridinepropanamine, .gamma.-(4-bromophenyl)-N,N-dimethyl-, (S)-; Pyridine, 2-[p-bromo-.alpha.-[2-(dimethylamino)ethyl]benzyl]-, (S)-
Clinical Status
Approved
Disease Indication Allergic rhinitis ICD-11: CA08 [1]
PubChem CID
16960
Formula
C16H19BrN2
Canonical SMILES
CN(C)CC[C@@H](C1=CC=C(C=C1)Br)C2=CC=CC=N2
InChI
1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1
InChIKey
ZDIGNSYAACHWNL-HNNXBMFYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=16960"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 319.24 Topological Polar Surface Area 16.1
XlogP 3.5 Complexity 249
Heavy Atom Count 19 Rotatable Bond Count 5
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Dexbrompheniramine 1 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Sucralose; Magnesium stearate; Mannitol; Xylitol; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Chewable Tablet
                   Company Carwin Pharmaceutical Associates
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Dexbrompheniramine 2 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Calcium phosphate, dibasic, dihydrate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Poly Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
References
1 FDA label for approved dexbrompheniramine from the official website of the U.S. Food and Drug Administration.
2 Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose. ACS Med Chem Lett. 2018 May 10; 9(7):657-661.
3 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
5 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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