Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00334)
Name
Isosorbide mononitrate
Synonyms    Click to Show/Hide the Synonyms of This API
ISOSORBIDE MONONITRATE; Isosorbide 5-mononitrate; 16051-77-7; Monosorbitrate; Elantan; Corangin; Monoket; Mononit; Isosorbide-5-mononitrate; Isosorbide 5-nitrate; Monolong; Monopront; Monosordil; Nitramin; Orasorbil; Promocard; Sigacora; Sorbimon; Turimonit; Vasdilat; Duride; Imtrate; Ismexin; Medocor; Monicor; Olicard; Pertil; Uniket; Monodur Durules; Mono Corax; Monisid; Isosorbidi mononitras [Latin]; Isosorbidi mononitras; Mononitrate d'isosorbide [French]; Mononitrate d'isosorbide; Mononitrato de isosorbida [Spanish]; Mononitrato de isosorbida; 1,4:3,6-Dianhydro-D-glucitol 5-nitrate; IS 5-MN; AHR-4698; D-Glucitol, 1,4:3,6-dianhydro-, 5-nitrate; IS-5-MN; UNII-LX1OH63030; 1,4:3,6-dianhydro-5-O-nitro-D-erythro-hexitol; Monizid; vasotrate; Epicordin; Monoclair; Monotrate; Olicardin; Percorina; Edistol; Etimonis; Isomonat; Isomonit; Multitab; Titarane; Conpin; Imazin; Imodur; Isomon; Iturol; Plodin; MonoSigma; IS-5MN; Elantan Retard; Mono-Sanorania; Monoket Retard; Elantan Long; Imdur Durules; Corangin SR; Mono Mack; Mono-Mack; Conpin Retardkaps; Fem-Mono; ISMN Lannacher; Monoket OD; ISMN Apogepha; ISMN Heumann; ISMN Basics; Pentacard 20; [(3S,3aR,6R,6aS)-3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate; 1,4:3,6-dianhydro-5-O-nitro-D-glucitol; BM 22.145; BM-22-145; Mono Corax Retard; CHEBI:6062; ISMN Hexal; ISMN Stada; Monocord 20; Monocord 40; Monolong 40; Monolong 60; ISMN Atid; Mononit 20; Mononit 40; Isopen-20; Monocord 50 SR; Mononit Retard 50; 5-Ismn; Imdur 60; ISMN AbZ; LX1OH63030; Monit 20; ISMN AL; Ismo-20; MFCD00143462; isosorbide-5-nitrate; Monocedocard; IS 5MN; Monosorb; (3r,3as,6s,6ar)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl nitrate; (3R,3aS,6S,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl nitrate; Glucitol, 1,4:3,6-dianhydro-, 5-nitrate, D-; Monocord; Monomax; AHR 4698; Monosorb XL 60; CCRIS 1911; Imdur (TN); Isosorbide Mononitrate (Isosorbide 5-Nitrate); Ismo (TN); BM 22-145; SR-05000001872; EINECS 240-197-2; UN3251; BRN 5851319; Leicester; Iso-5-mononitrate; NCGC00159334-02; isorbide mononitrate; PubChem5881; Isosobide-5-mononitrate; 5-Isosorbide mononitrate; DSSTox_CID_3176; Isosorbide Mononitrate,(S); CHEMBL1311; DSSTox_RID_76905; DSSTox_GSID_23176; Isosorbide mononitrate [USAN:USP:INN:BAN:JAN]; SCHEMBL26781; Diluted isosorbide mononitrate; ARONIS24085; GTPL7052; DTXSID9023176; NIOSH/LZ4385560; HMS2093K07; HMS3715I08; Pharmakon1600-01503807; HY-B0642; ZINC1849548; Tox21_111581; ANW-41163; NSC758619; SBB080596; AKOS005110986; AC-8830; CCG-213200; CS-3495; DB01020; NSC-758619; Isosorbide mononitrate (JP17/USP/INN); NCGC00167981-01; NCGC00167981-03; BM-22145; D-1,4:3,6-Dianhydroglucitol 5-nitrate; 1,4:3,6-Dianhydrosorbitol 5-mononitrate; SBI-0206724.P001; BM-22.145; CAS-16051-77-7; BB 0261072; BM 22.145IS 5-MNAHR-4698; Isosorbide dinitrate isosorbide-5-mononitrate; LZ43855600; C07714; D00630; AB01563284_01; Q423401; SR-05000001872-1; SR-05000001872-2; W-107977; BRD-K82225283-001-01-5; Isosobide-5-mononitrate [UN3251] [Flammable solid]; Isosorbide Mononitrate 1.0 mg/ml in Dimethyl Sulfoxide; (2S,5S,1R,6R)-6-(nitrooxy)-4,8-dioxabicyclo[3.3.0]octan-2-ol; [(3R,3aS,6S,6aR)-6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl] nitrate
Clinical Status
Approved
Disease Indication Angina pectoris ICD-11: BA40 [1]
PubChem CID
27661
Formula
C6H9NO6
Canonical SMILES
C1[C@@H]([C@@H]2[C@H](O1)[C@@H](CO2)O[N+](=O)[O-])O
InChI
1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5+,6+/m0/s1
InChIKey
YWXYYJSYQOXTPL-SLPGGIOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=27661"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 191.14 Topological Polar Surface Area 93.7
XlogP -0.4 Complexity 216
Heavy Atom Count 13 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Isosorbide mononitrate 30 mg tablet Click to Show/Hide the Full List of Formulation(s):        18 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; D&c red no. 30; D&c red no. 27; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Polysorbate 80; Silicon dioxide; Carnauba wax; Ethylcelluloses; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company NCS HealthCare of KY, Inc dba Vangard Labs; RemedyRepack; Zydus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [2]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Diethyl phthalate; Magnesium stearate; Talc; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hydrogenated castor oil; Hydroxypropyl cellulose (type e); Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Diethyl phthalate; Magnesium stearate; Talc; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hydrogenated castor oil; Hydroxypropyl cellulose (type h); Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Cardinal Health; NCS HealthCare of KY, Inc dba Vangard Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Diethyl phthalate; Magnesium stearate; Talc; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hydrogenated castor oil; Hydroxypropyl cellulose; Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company NuCare Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Diethyl phthalate; Magnesium stearate; Talc; Titanium dioxide; Silicon dioxide; Hydrogenated castor oil; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2910 (6 mpa.s); Microcrystalline cellulose
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Diethyl phthalate; Magnesium stearate; Talc; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hydrogenated castor oil; Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products; McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Diethyl phthalate; Magnesium stearate; Talc; Titanium dioxide; Cellulose, microcrystalline; Colloidal silicon dioxide; Hydrogenated castor oil; Hydroxypropyl cellulose; Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Torrent Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ammonium phosphate, dibasic; Ferric oxide red; Titanium dioxide; Silicon dioxide; Carnauba wax; Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ammonium phosphate, dibasic; Ferric oxide red; Titanium dioxide; Silicon dioxide; Carnauba wax; Polyethylene glycol, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ammonium phosphate, dibasic; Ferric oxide red; Titanium dioxide; Silicon dioxide; Carnauba wax; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company McKesson; NCS HealthCare of KY, Inc dba Vangard Labs; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ammonium phosphate, dibasic; Ferric oxide red; Titanium dioxide; Silicon dioxide; Carnauba wax; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ammonium phosphate, dibasic; Silicon dioxide; Carnauba wax; Hypromelloses; Paraffin
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Silicon dioxide; Hydrogenated castor oil; Hypromellose 2208 (100 mpa.s); Microcrystalline cellulose
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Silicon dioxide; Hydrogenated castor oil; Hypromellose, unspecified; Microcrystalline cellulose
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Silicon dioxide; Cellulose, microcrystalline; Hydrogenated castor oil; Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Sucrose; Silicon dioxide; Hydroxypropyl cellulose (type h)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Heritage Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Hydrogenated castor oil; Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company McKesson; NCS HealthCare of KY, Inc dba Vangard Labs; NuCare Pharmaceuticals; Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Hydrogenated castor oil; Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Isosorbide mononitrate 60 mg tablet Click to Show/Hide the Full List of Formulation(s):        15 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; D&c yellow no. 10; Fd&c blue no. 2; Magnesium stearate; Titanium dioxide; Polysorbate 80; Silicon dioxide; Carnauba wax; Ethylcelluloses; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company NCS HealthCare of KY, Inc dba Vangard Labs; Zydus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Diethyl phthalate; Magnesium stearate; Talc; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hydrogenated castor oil; Hydroxypropyl cellulose (type e); Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Diethyl phthalate; Magnesium stearate; Talc; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hydrogenated castor oil; Hydroxypropyl cellulose (type h); Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Blenheim Phamacal; NCS HealthCare of KY, Inc dba Vangard Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Diethyl phthalate; Magnesium stearate; Talc; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hydrogenated castor oil; Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Diethyl phthalate; Magnesium stearate; Talc; Titanium dioxide; Cellulose, microcrystalline; Colloidal silicon dioxide; Hydrogenated castor oil; Hydroxypropyl cellulose; Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Torrent Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ammonium phosphate, dibasic; Ferric oxide yellow; Titanium dioxide; Silicon dioxide; Carnauba wax; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company McKesson; NCS HealthCare of KY, Inc dba Vangard Labs; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ammonium phosphate, dibasic; Ferric oxide yellow; Titanium dioxide; Silicon dioxide; Carnauba wax; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Ammonium phosphate, dibasic; Silicon dioxide; Carnauba wax; Hypromelloses; Paraffin
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Silicon dioxide; Hydrogenated castor oil; Hypromellose 2208 (100 mpa.s); Microcrystalline cellulose
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Silicon dioxide; Hydrogenated castor oil; Hypromellose, unspecified; Microcrystalline cellulose
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Talc; Silicon dioxide; Cellulose, microcrystalline; Hydrogenated castor oil; Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Sucrose; Silicon dioxide; Hydroxypropyl cellulose (type h)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Heritage Pharmaceuticals; NuCare Pharmaceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Sucrose; Silicon dioxide; Hydroxypropyl cellulose (1200000 mw)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Sucrose; Silicon dioxide; Hydroxypropyl cellulose
                   Dosage Form 24 HR Extended Release Tablet
                   Company Alvogen
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Hydrogenated castor oil; Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company A-S Medication Solutions; McKesson; NCS HealthCare of KY, Inc dba Vangard Labs; NuCare Pharmaceuticals; Par Pharmaceutical; Proficient Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Isosorbide mononitrate 120 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Diethyl phthalate; Magnesium stearate; Talc; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hydrogenated castor oil; Hydroxypropyl cellulose (type e); Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Diethyl phthalate; Magnesium stearate; Talc; Titanium dioxide; Cellulose, microcrystalline; Colloidal silicon dioxide; Hydrogenated castor oil; Hydroxypropyl cellulose; Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Torrent Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Titanium dioxide; Polysorbate 80; Silicon dioxide; Carnauba wax; Ethylcelluloses; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Zydus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Hydrogenated castor oil; Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Bryant Ranch Prepack; Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Isosorbide mononitrate 10 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Fd&c blue no. 1; Talc; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company NCS HealthCare of KY, Inc dba Vangard Labs; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Fd&c blue no. 1; Talc; Silicon dioxide; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Aluminum stearate; Talc; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Kremers Urban Pharmaceuticals Inc.
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Aluminum stearate; Talc; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company UCB
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Isosorbide mononitrate 20 mg tablet Click to Show/Hide the Full List of Formulation(s):          7 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Fd&c blue no. 1; Talc; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Avera McKennan Hospital; NCS HealthCare of KY, Inc dba Vangard Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Fd&c blue no. 1; Talc; Silicon dioxide; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Fd&c blue no. 1; Talc; Cellulose, microcrystalline; Colloidal silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ammonium phosphate, dibasic; Titanium dioxide; Povidone; Cellulose, microcrystalline; Colloidal silicon dioxide; Hypromellose 2208 (100 cps); Polyethylene glycol; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Aluminum stearate; Talc; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Kremers Urban Pharmaceuticals Inc.
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; Aluminum stearate; Talc; Silicon dioxide; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Carilion Materials Management; Proficient Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Aluminum stearate; Talc; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company UCB
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Isosorbide 10mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Cellulose; Magnesium Stearate; D&C Yellow 10; Fd&C Blue 1; Fd&C Yellow 6
                   Dosage Form Tablet
                   Company Bausch
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Cellulose; Magnesium Stearate; Fd&C Red 40
                   Dosage Form Tablet
                   Company Bausch
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
References
1 FDA label for approved isosorbide mononitrate from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4 PubChem BioAssay data set.
5 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
6 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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