Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00417)
Name
Methyldopa
Synonyms    Click to Show/Hide the Synonyms of This API
methyldopa; 555-30-6; Alphamethyldopa; Aldomet; Dopamet; Alpha medopa; Methyl dopa; l-alpha-Methyldopa; alpha-Methyl dopa; Baypresol; Hyperpax; Presolisin; Sedometil; Medomet; L-(-)-alpha-Methyldopa; Methyldopa anhydrous; 3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE; Methyl-L-dopa; L-Methyl Dopa; Methyldopum; Metildopa; (S)-(-)-alpha-Methyldopa; L-(alpha-Md); 3-Hydroxy-alpha-methyl-L-tyrosine; L-alpha-Methyl DOPA; Sembrina; Dopegyt; alpha-Methyl-L-dopa; Dopamethyperpax; Aldometil; Grospisk; Medopren; Methoplain; Presinol; Becanta; Dopatec; Hypolag; Medopa; Medopal; alpha-Methyldopa (VAN); alpha-Methyldopa; Aldoril; alpha-Methyldihydroxyphenylalanine; alpha-Methyl-L-3,4-dihydroxyphenylalanine; L-alpha-Methyl-3,4-dihydroxyphenylalanine; L-Methyldopa; l-3-(3,4-Dihydroxyphenyl)-2-methylalanine; (S)-2-Amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid; Aldoril D30; Aldoril D50; Methyldopa (L,-); Bayer 1440 L; levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine; C10H13NO4; L-(-)-3-(3,4-Dihydroxyphenyl)-2-methylalanine; alpha-Methyl-beta-(3,4-dihydroxyphenyl)-L-alanine; L(-)-beta-(3,4-Dihydroxyphenyl)-alpha-methylalanine; L-(-)-alpha-Methyl-beta-(3,4-dihydroxyphenyl)alanine; UNII-M4R0H12F6M; Methyldopa (INN); Methyldopa [INN]; L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic acid; (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid; MK-351;Methyldopa; CHEBI:61058; 41372-08-1; alpha-Methyldopa sesquihydrate; Aldomet (TN); Dopegit; MLS000028644; M4R0H12F6M; MK-351; Apo-Methyldopa; Nu-Medopa; Methyldopa hydrate; Novomedopa; SMR000059170; Methyldopum [INN-Latin]; Metildopa [INN-Spanish]; 3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate; Methyldopa (anhydrous); 3-Hydroxy-.alpha.-methyl-L-tyrosine; L-Tyrosine, 3-hydroxy-alpha-methyl-; CCRIS 4671; HSDB 218; SR-01000597712; EINECS 209-089-2; Methyldopa (Levorotatory); NSC 169916; Medoba; l-a-methyldopa; a-methyl dopa; NSC169916; a-methyl-l-dopa; 3,4-Dihydroxy-2-methylphenylalanine #; NSC-169916; Anhydrous methyldopa; CAS-555-30-6; Prestwick_732; (-)-a-methyldopa; a-methyldopa (van); Methyldopa (Aldomet); 88620-56-8; Alanine, 3-(3,4-dihydroxyphenyl)-2-methyl-, L-(-)-; Methyldopa 250 Tab; (-)-alpha-methyldopa; L-(-)--Methyldopa; L(-)-a-methylalanine; Spectrum_000937; Tocris-0584; MK-351; Methyldopa; Nu-Medopa Tab 125mg; Nu-Medopa Tab 250mg; Nu-Medopa Tab 500mg; L-(-)-?-Methyldopa; (-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-Alanine Sesqui-Hydrate; Novo-Medopa Tab 125mg; Novo-Medopa Tab 250mg; Novo-Medopa Tab 500mg; Prestwick0_000326; Prestwick1_000326; Prestwick2_000326; Prestwick3_000326; Spectrum2_001068; Spectrum3_000501; Spectrum4_000054; Spectrum5_001295; (s)-(-)-a-methyldopa; L(-)-alpha-methylalanine; DSSTox_CID_3295; CHEMBL459; Epitope ID:146097; L-(-)- alpha-Methyldopa; Apo Methyldopa Tab 125mg; Apo Methyldopa Tab 250mg; Apo Methyldopa Tab 500mg; DSSTox_RID_76962; DSSTox_GSID_23295; L-(a-MD); Lopac0_000853; SCHEMBL34003; BSPBio_000331; BSPBio_002021; KBioGR_000547; KBioSS_001417; cid_38853; MLS006011978; BAYER-1440L; BIDD:GT0620; DivK1c_000142; Methyldopa 125 Tab 125mg; Methyldopa 500 Tab 500mg; SPECTRUM1500403; SPBio_001056; SPBio_002252; alpha-Methyl-dopa sesquihydrate; BPBio1_000365; GTPL5217; DTXSID5023295; BDBM48449; HMS500H04; KBio1_000142; KBio2_001417; KBio2_003985; KBio2_006553; KBio3_001521; ZINC20255; 5-amino-2-fluorophenylboronicacid; NINDS_000142; HMS1569A13; HMS1920N09; HMS2090B11; HMS2091F04; HMS2096A13; HMS2235N11; HMS3262L07; HMS3372J14; HMS3411G18; HMS3675G18; HMS3713A13; HMS3887I15; Pharmakon1600-01500403; L-(-)-a-methyl-a-methyl-Aldomin; HY-B0225; Tox21_202610; Tox21_500853; ANW-43632; CCG-40120; CM0081; DL-443; MFCD00004186; NSC760080; Tyrosine, 3-hydroxy-.alpha.-methyl-; a-Methyl-L-3,4-dihydroxyphenylalanine; AKOS015960582; AC-8431; DB00968; J9.247I; KS-1424; LP00853; MCULE-8885874119; NSC-760080; SDCCGSBI-0050829.P002; IDI1_000142; NCGC00024667-01; NCGC00024667-02; NCGC00024667-03; NCGC00024667-05; NCGC00024667-06; NCGC00024667-07; NCGC00024667-08; NCGC00024667-09; NCGC00024667-10; NCGC00024667-11; NCGC00024667-13; NCGC00024667-21; NCGC00260158-01; NCGC00261538-01; AC-11671; AK114179; AS-13052; L-(-)-alpha-methyl-alpha-methyl-Aldomin; L-a-Methyl-(3, 4-dihydroxyphenyl)alanine; EU-0100853; 3-(3,4-Dihydroxyphenyl)-?-methyl-L-alanine; L-alpha-Methyl-(3, 4-dihydroxyphenyl)alanine; C07194; D08205; AB00052043_09; AB01275508-01; AB01275508_02; 3-(3,4-Dihydroxyphenyl)-alpha-methyl-L-a lanine; Q412621; L-(-)-3-(3,4-dihydroxyphenyl)-2-methyl-Alanine; Q-201392; SR-01000597712-1; SR-01000597712-3; W-105555; 3,4-dihydroxy-2-methylphenylalanine (ACD/Name 4.0); Z1565440340; Methyldopa, European Pharmacopoeia (EP) Reference Standard; UNII-33TD13T99R component CJCSPKMFHVPWAR-JTQLQIEISA-N; (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propanoic acid; Methyldopa, United States Pharmacopeia (USP) Reference Standard; L-(-)-AfAE'A centa' notA inverted exclamation markAfasA'A; AfAE'Adaggeratrade mark?-Methyldopa
Clinical Status
Approved
Disease Indication Essential hypertension ICD-11: BA00 [1]
PubChem CID
38853
Formula
C10H13NO4
Canonical SMILES
C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)N
InChI
1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1
InChIKey
CJCSPKMFHVPWAR-JTQLQIEISA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=38853"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 211.21 Topological Polar Surface Area 104
XlogP -1.9 Complexity 246
Heavy Atom Count 15 Rotatable Bond Count 3
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Methyldopa 250 mg tablet Click to Show/Hide the Full List of Formulation(s):          8 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Triacetin; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polydextrose; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company Cardinal Health; Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Citric acid; Magnesium stearate; Calcium sulfate; Edetate disodium; Talc; Titanium dioxide; Silicon dioxide; Ethylcellulose (10 mpa.s); Hydroxypropyl cellulose; Hypromelloses; Methylcellulose (15 cps); Polyethylene glycol; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Povidone; Cellulose, microcrystalline; Hypromelloses; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Accord Healthcare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Cellulose, microcrystalline; Hypromelloses; Povidones; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Calcium sulfate; Citric acid monohydrate; Edetate disodium; Talc; Titanium dioxide; Silicon dioxide; Ethylcelluloses; Hydroxypropyl cellulose; Hypromelloses; Methylcellulose (400 cps); Polyethylene glycol; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Calcium sulfate; Citric acid monohydrate; Edetate disodium; Talc; Titanium dioxide; Silicon dioxide; Ethylcelluloses; Hydroxypropyl cellulose (type h); Hypromellose 2910 (3 mpa.s); Methylcellulose (400 mpa.s); Polyethylene glycols; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Calcium sulfate; Citric acid monohydrate; Edetate disodium; Talc; Titanium dioxide; Silicon dioxide; Ethylcelluloses; Hydroxypropyl cellulose (type h); Hypromelloses; Methylcellulose (400 mpa.s); Polyethylene glycols; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Calcium sulfate; Citric acid monohydrate; Edetate disodium; Talc; Titanium dioxide; Silicon dioxide; Ethylcelluloses; Hydroxypropyl cellulose; Hypromelloses; Methylcellulose (400 mpa.s); Polyethylene glycols; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Methyldopa 500 mg tablet Click to Show/Hide the Full List of Formulation(s):          6 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Triacetin; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polydextrose; Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Citric acid; Magnesium stearate; Edetate disodium; Titanium dioxide; Polysorbate 80; Silicon dioxide; Ethylcellulose (10 mpa.s); Hypromelloses; Methylcellulose (15 cps); Polyethylene glycol; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [5]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Povidone; Cellulose, microcrystalline; Hypromelloses; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Accord Healthcare; Avera McKennan Hospital
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [6]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Hypromellose, unspecified; Microcrystalline cellulose; Povidone, unspecified; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Citric acid monohydrate; Edetate disodium; Titanium dioxide; Polysorbate 80; Silicon dioxide; Ethylcelluloses; Hypromelloses; Methylcellulose (400 cps); Polyethylene glycol; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Calcium sulfate; Citric acid monohydrate; Edetate disodium; Talc; Titanium dioxide; Silicon dioxide; Ethylcelluloses; Hydroxypropyl cellulose (type h); Hypromellose 2910 (3 mpa.s); Methylcellulose (400 mpa.s); Polyethylene glycols; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
References
1 FDA label for approved methyldopa from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
5 PubChem BioAssay data set.
6 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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