Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00472)
Name
Nisoldipine
Synonyms    Click to Show/Hide the Synonyms of This API
nisoldipine; 63675-72-9; Nisocor; Zadipina; Bay k 5552; Nisoldipinum; Baymycard; Syscor; Nisoldipinum [INN-Latin]; Nisoldipino [INN-Spanish]; Bay-k-5552; BAY-k 5552; CHEBI:76917; MFCD00478055; CHEMBL441428; Nisoldipin; Nisoldipino; NCGC00164633-01; DSSTox_CID_3371; DSSTox_RID_76999; DSSTox_GSID_23371; SMR000466370; CAS-63675-72-9; Sular (TN); SR-05000002009; EINECS 264-407-7; BRN 0454188; Nisoldipine (JAN/USAN/INN); Nisoldipine;; Nisoldipine,(S); Nisoldipine [USAN:INN:BAN:JAN]; Nisoldipine, ~97%; (.+/-.)-Nisoldipine; CHEMBL1726; SCHEMBL39779; MLS000759498; MLS001424102; MLS002153943; BIDD:GT0684; GTPL2524; CHEMBL3192341; DTXSID0023371; Nisoldipine, >=98% (HPLC); HMS2051O18; HMS2089K20; HMS2093F15; HMS2097E13; HMS2231L20; HMS3393O18; HMS3651K17; HMS3714E13; HMS3744O19; HMS3884I08; Pharmakon1600-01505390; BCP22696; Tox21_112251; Tox21_302365; AC-987; BBL028683; BDBM50101963; BDBM50227259; DL-255; KM0774; NSC759106; STK631543; AKOS005563632; Tox21_112251_1; CCG-100894; CCG-213412; CS-1131; DB00401; KS-5188; MCULE-5009799152; NC00144; Nisoldipine 100 microg/mL in Methanol; NSC-759106; Bay K 5552;BAY-K 5552;Sular; NCGC00164633-02; NCGC00164633-03; NCGC00255136-01; 6-BROMO-2,3-DIMETHOXYBENZOICACID; AK143131; HY-17402; SBI-0206830.P001; AB0106136; FT-0601599; SW219237-1; C07699; D00618; J10291; AB01275444-01; AB01275444_02; 675N729; A834466; Q3342150; SR-05000002009-1; SR-05000002009-2; SR-05000002009-3; BRD-A84465106-001-01-2; Z277942268
Clinical Status
Approved
Disease Indication Essential hypertension ICD-11: BA00 [1]
PubChem CID
4499
Formula
C20H24N2O6
Canonical SMILES
CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
InChI
1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
InChIKey
VKQFCGNPDRICFG-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4499"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 388.4 Topological Polar Surface Area 110
XlogP 3.3 Complexity 704
Heavy Atom Count 28 Rotatable Bond Count 7
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 7
Full List of Drug Formulations (DFMs) Containing This API
          Nisoldipine 17 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium lauryl sulfate; Fd&c yellow no. 5; Glyceryl behenate; Magnesium stearate; Ferric oxide yellow; Titanium dioxide; Hypromellose; Povidone; Silicon dioxide; Carnauba wax; Methacrylic acid - methyl methacrylate copolymer (1:1); Polydextrose; Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company United Research Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hydrazine yellow DIG Info GABA(A) receptor alpha-1 (IC50 = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Triacetin; Silicon dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Polydextrose; Polyethylene glycol, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium lauryl sulfate; Fd&c yellow no. 5; Glyceryl dibehenate; Magnesium stearate; Ferric oxide red; Titanium dioxide; Povidone; Silicon dioxide; Carnauba wax; Hypromellose phthalate (24% phthalate, 55 cst); Hypromelloses; Methacrylic acid - methyl methacrylate copolymer (1:1); Polydextrose; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Prasco
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hydrazine yellow DIG Info GABA(A) receptor alpha-1 (IC50 = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; Sodium lauryl sulfate; Fd&c yellow no. 5; Glyceryl dibehenate; Magnesium stearate; Ferric oxide red; Titanium dioxide; Silicon dioxide; Carnauba wax; Hypromellose phthalate (24% phthalate, 55 cst); Hypromellose, unspecified; Methacrylic acid - methyl methacrylate copolymer (1:2); Polydextrose; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Covis Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hydrazine yellow DIG Info GABA(A) receptor alpha-1 (IC50 = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium lauryl sulfate; Fd&c yellow no. 5; Glyceryl dibehenate; Magnesium stearate; Ferric oxide red; Titanium dioxide; Silicon dioxide; Carnauba wax; Hypromellose phthalate (24% phthalate, 55 cst); Hypromelloses; Methacrylic acid - methyl methacrylate copolymer (1:2); Polydextrose; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Shionogi
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hydrazine yellow DIG Info GABA(A) receptor alpha-1 (IC50 = 13 uM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Nisoldipine 25.5 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium lauryl sulfate; Glyceryl behenate; Magnesium stearate; Ferric oxide yellow; Titanium dioxide; Hypromellose; Povidone; Silicon dioxide; Carnauba wax; Methacrylic acid - methyl methacrylate copolymer (1:1); Polydextrose; Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company United Research Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium lauryl sulfate; Glyceryl behenate; Magnesium stearate; Ferric oxide yellow; Titanium dioxide; Povidone; Silicon dioxide; Carnauba wax; Hypromellose phthalate (24% phthalate, 55 cst); Hypromelloses; Methacrylic acid - methyl methacrylate copolymer (1:1); Polydextrose; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Triacetin; Silicon dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Polydextrose; Polyethylene glycol, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium lauryl sulfate; Glyceryl dibehenate; Magnesium stearate; Ferric oxide yellow; Titanium dioxide; Silicon dioxide; Carnauba wax; Hypromellose phthalate (24% phthalate, 55 cst); Hypromelloses; Methacrylic acid - methyl methacrylate copolymer (1:1); Polydextrose; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Tablet
                   Company Shionogi
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Nisoldipine 34 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium lauryl sulfate; Glyceryl behenate; Magnesium stearate; Ferric oxide yellow; Titanium dioxide; Hypromellose; Povidone; Silicon dioxide; Carnauba wax; Methacrylic acid - methyl methacrylate copolymer (1:1); Polydextrose; Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company United Research Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium lauryl sulfate; Glyceryl dibehenate; Magnesium stearate; Ferric oxide red; Titanium dioxide; Povidone; Silicon dioxide; Carnauba wax; Hypromellose phthalate (24% phthalate, 55 cst); Hypromelloses; Methacrylic acid - methyl methacrylate copolymer (1:1); Polydextrose; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Prasco
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Triacetin; Silicon dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Polydextrose; Polyethylene glycol, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; Sodium lauryl sulfate; Glyceryl dibehenate; Magnesium stearate; Ferric oxide red; Titanium dioxide; Silicon dioxide; Carnauba wax; Hypromellose phthalate (24% phthalate, 55 cst); Hypromellose, unspecified; Methacrylic acid - methyl methacrylate copolymer (1:2); Polydextrose; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Covis Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium lauryl sulfate; Glyceryl dibehenate; Magnesium stearate; Ferric oxide red; Titanium dioxide; Silicon dioxide; Carnauba wax; Hypromellose phthalate (24% phthalate, 55 cst); Hypromelloses; Methacrylic acid - methyl methacrylate copolymer (1:2); Polydextrose; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Shionogi
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Nisoldipine 8.5 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium lauryl sulfate; Glyceryl behenate; Magnesium stearate; Ferric oxide yellow; Titanium dioxide; Hypromellose; Povidone; Silicon dioxide; Carnauba wax; Methacrylic acid - methyl methacrylate copolymer (1:1); Polydextrose; Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company United Research Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium lauryl sulfate; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Triacetin; Silicon dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Polydextrose; Polyethylene glycol, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium lauryl sulfate; Glyceryl dibehenate; Magnesium stearate; Ferric oxide red; Titanium dioxide; Povidone; Silicon dioxide; Carnauba wax; Hypromellose phthalate (24% phthalate, 55 cst); Hypromelloses; Methacrylic acid - methyl methacrylate copolymer (1:1); Polydextrose; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Prasco
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; Sodium lauryl sulfate; Glyceryl dibehenate; Magnesium stearate; Ferric oxide red; Titanium dioxide; Silicon dioxide; Carnauba wax; Hypromellose phthalate (24% phthalate, 55 cst); Hypromellose, unspecified; Methacrylic acid - methyl methacrylate copolymer (1:2); Polydextrose; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Covis Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium lauryl sulfate; Glyceryl dibehenate; Magnesium stearate; Ferric oxide red; Titanium dioxide; Silicon dioxide; Carnauba wax; Hypromellose phthalate (24% phthalate, 55 cst); Hypromelloses; Methacrylic acid - methyl methacrylate copolymer (1:2); Polydextrose; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Shionogi
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Nisoldipine 40 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Silicon dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Polydextrose; Polyethylene glycol, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Silicon dioxide; Hydroxypropyl cellulose; Hypromelloses; Hypromelloses; Polydextrose; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Nisoldipine 20 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Titanium dioxide; Triacetin; Silicon dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Polydextrose; Polyethylene glycol, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Nisoldipine 30 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Triacetin; Silicon dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Polydextrose; Polyethylene glycol, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
References
1 FDA label for approved nisoldipine from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
5 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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