Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E08XEK)
DIG Name	Hydrazine yellow
Synonyms	Click to Show/Hide the Synonyms of This DIG Tartrazine; 1934-21-0; Acid yellow 23; Yellow 5; Aizen tartrazine; Food Yellow 4; FD & C Yellow no. 5; trisodium salt; C.I. ACID YELLOW 23; A.F. Yellow No. 4; FD&C Yellow No. 5 Aluminum Lake; C.I. 19140; Tartrazine FD&C Yellow #5; Tartraphenine; Atul Tartrazine; Erio Tartrazine; Kako Tartrazine; Tartran Yellow; Tartrazine Lake; Tartrazine B; Tartrazine C; Tartrazine G; Tartrazine M; Tartrazine N; Tartrazine O; Tartrazine T; CI 19140; HD Tartrazine; Hydrazine Yellow; Lake Yellow; Sugai Tartrazine; Tartrazine FQ; Tartrazine NS; Tartrazine XX; Tartrazol Yellow; Wool Yellow; Tartrazine XXX; Tartrazine MCGL; Tartrazol BPC; Amacid Yellow T; Cilefa Yellow T; Dye Yellow Lake; Fenazo Yellow T; Kayaku Tartrazine; Mitsui Tartrazine; Oxanal Yellow T; Tartar Yellow N; Tartar Yellow S; Tartrazine Yellow; Kiton Yellow T; Lemon Yellow A; Acid Yellow T; Bucacid tartrazine; Dolkwal tartrazine; Hexacol Tartrazine; Hidazid Tartrazine; Acilan Yellow GG; Egg Yellow A; San-ei Tartrazine; Tartar Yellow FS; Tartar Yellow PF; 12225-21-7; Airedale Yellow T; Canacert tartrazine; Food Yellow 5; Neklacid Yellow T; Tartrine Yellow O; Eurocert Tartrazine; Vondacid Tartrazine; Hydroxine Yellow L; Tartrazine C Extra; Calcocid Yellow XX; KCA Tartrazine PF; Yellow Lake 69; Naphtocard Yellow O; Tartrazine A Export; 1342-47-8; HD Tartrazine Supra; Calcocid Yellow MCG; Tartrazine Yellow 5; Yellow No. 5; Tartrazine A expo T; Tartrazine B.P.C.; D&C Yellow 5; Food Yellow No. 4; Lemon Yellow A Geigy; Schultz No. 737; Maple Tartrazol Yellow; Acid Leather Yellow T; C.I. 640; Unitertracid Yellow TE; Yellow No. 5 FDC; Curon Fast Yellow 5G; FD And C Yellow 5; 1310 Yellow; 1409 Yellow; Xylene Fast Yellow GT; Hispacid Fast Yellow T; Usacert Yellow No. 5; C.I. Food Yellow 4; Hexacert Yellow No. 5; CHEBI:9405; FD&G Yellow No. 5; Tartrazine Extra Pure A; L Yellow Z 1020; Tartrazine Lake Yellow N; Edicol Supra Tartrazine N; D and C Yellow No. 5; KCA Foodcol Tartrazine PF; Certicol Tartrazol Yellow S; Tartrazine O Specially Pure; Tartrazine XX Specially Pure; MFCD00148908; Dye FD and C Yellow No. 5; Tartrazine FD & C Yellow #5; E102; Kayaku Food Colour Yellow No. 4; Tartrazine, 89%, pure; Food Yellow 4:1; C.I. Acid Yellow 23, trisodium salt; m-8847; 1H-Pyrazole-3-carboxylic acid, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-(2-(4-sulfophenyl)diazenyl)-, sodium salt (1:3); 1H-Pyrazole-3-carboxylic acid,4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-, trisodiumsalt; sodium (E)-5-oxo-1-(4-sulfonatophenyl)-4-((4-sulfonatophenyl)diazenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate; FD&C Yellow No. 5; trisodium 5-oxo-1-(4-sulfonatophenyl)-4-(4-sulfonatophenyl)diazenyl-4H-pyrazole-3-carboxylate; NSC4760; Zlut kysela 23; 4,5-Dihydro-5-oxo-1-(4-sulfophenyl)-4-((4-sulfophenyl)azo)-1H-pyrazole-3-carboxylic acid, trisodium salt; Trisodium 5-oxo-1-(4-sulfonatophenyl)-4-[(E)-(4-sulfonatophenyl)diazenyl]-4,5-dihydro-1H-pyrazole-3-carboxylate; Zlut pigment 100; Zlut potravinarska 4; 3-Carboxy-5-hydroxy-1-p-sulfophenyl-4-p-sulfophenylazopyrazole trisodium salt; L-Gelb 2; L-Gelb 2 [German]; Zlut kysela 23 [Czech]; Zlut pigment 100 [Czech]; Zlut potravinarska 4 [Czech]; tri sodium salt; CCRIS 2656; HSDB 7216; FD & C Yellow No. 5 tartrazine; NSC 4760; Food yellow No.4; EINECS 217-699-5; E 102; Epitope ID:124945; Tartrazine, analytical standard; Tartrazine (C.I. 19140); Tartrazine, p.a., 95-105%; Tartrazine, Dye content >=85 %; AMY22425; Trisodium salt of 3-carboxy-5-hydroxy-1-sulfophenylazopyrazole; Tartrazine, for microscopy (Hist.); 1-(4-Sulfophenyl)-4-((4-sulfophenyl)azo)-1H-pyrazole-3-carboxylic; AKOS015903034; AKOS016010270; Trisodium 3-carboxy-5-hydroxy-1-p-sulfophenyl-4-p-sulfophenylazopyrazole; Trisodium 5-hydroxy-1-(4-sulphophenyl)-4-(4-sulphophenylazo)pyrazole-3-carboxylate; BP-31013; Trisodium 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-((4-sulfophenyl)azo)-1H-pyrazole-3-carboxylate; Y-4; FT-0621860; C07574; Q407158; W-107716; C.I. Acid Yellow 23, trisodium salt (VAN) (8CI); TARTRAZINE LAKE, CI NO 19140:1 , FD & C YELLOW 5 LAKE; 4,5-Dihydro-5-oxo-1-(4-sulfophenyl)-4-((4-sulfophenyl)azo)-1H-pyrazole-3-carboxylic acid; 5-oxo-1-(4-sulfophenyl)-4-[(E)-(4-sulfophenyl)azo]-4H-pyrazole-3-carboxylic acid; Pyrazole-3-carboxylic acid, 5-hydroxy-1-(p-sulfophenyl)-4-(p-sulfophenyl)azo-, trisodium salt; Trisodium 5-oxo-1-(4-sulfonatophenyl)-4-[(E)-(4-sulfonatophenyl)d iazenyl]-4,5-dihydro-1H-pyrazole-3-carboxylate; trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(E)-(4-sulfonatophenyl)diazenyl]-4H-pyrazole-3-carboxylate
DIG Function	Colorant
PubChem CID	164825
Formula	C16H9N4Na3O9S2
Canonical SMILES	C1=CC(=CC=C1N=NC2C(=NN(C2=O)C3=CC=C(C=C3)S(=O)(=O)[O-])C(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+]
InChI	1S/C16H12N4O9S2.3Na/c21-15-13(18-17-9-1-5-11(6-2-9)30(24,25)26)14(16(22)23)19-20(15)10-3-7-12(8-4-10)31(27,28)29;;;/h1-8,13H,(H,22,23)(H,24,25,26)(H,27,28,29);;;/q;3*+1/p-3
InChIKey	UJMBCXLDXJUMFB-UHFFFAOYSA-K
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=164825"></iframe>
Structure	3D MOL is not available		2D MOL
Physicochemical Properties	Molecular Weight	534.4	Topological Polar Surface Area	229
	XlogP	N.A.	Complexity	949
	Heavy Atom Count	34	Rotatable Bond Count	3
	Hydrogen Bond Donor Count	0	Hydrogen Bond Acceptor Count	12

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Minocycline	API Info	Streptococcus bacterial infection [ICD-11: 1C41]		[1]
Metronidazole	API Info	Amebiasis [ICD-11: 1A36]		[2]
Primaquine	API Info	Malaria [ICD-11: 1F40]		[3]
Paromomycin	API Info	Amebiasis [ICD-11: 1A36]		[4]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Temozolomide	API Info	Brain cancer [ICD-11: 2A00]		[5]
Letrozole	API Info	Breast cancer [ICD-11: 2C60]		[6]
Niraparib	API Info	Ovarian cancer [ICD-11: 2C73]		[7]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Levothroid	API Info	Hypothyroidism [ICD-11: 5A00]		[8]
Phentermine	API Info	Obesity [ICD-11: 5B81]		[9]
Rosuvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[10]
Phendimetrazine	API Info	Obesity [ICD-11: 5B81]		[11]
Ergocalciferol	API Info	Hypoparathyroidism [ICD-11: 5A50]		[12]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Risperidone	API Info	Schizophrenia [ICD-11: 6A20]		[13]
Bupropion	API Info	Nicotine dependence [ICD-11: 6C4A]		[14]
Alprazolam	API Info	Anxiety disorder [ICD-11: 6B00]		[15]
Venlafaxine	API Info	Major depressive disorder [ICD-11: 6A70]		[16]
Amitriptyline	API Info	Major depressive disorder [ICD-11: 6A70]		[17]
Hydroxyzine	API Info	Anxiety disorder [ICD-11: 6B00]		[18]
Paroxetine	API Info	Major depressive disorder [ICD-11: 6A70]		[19]
Quetiapine	API Info	Schizophrenia [ICD-11: 6A20]		[20]
Imipramine	API Info	Major depressive disorder [ICD-11: 6A70]		[21]
Milnacipran	API Info	Asperger syndrome [ICD-11: 6A02]		[22]
ICD Disease Classification 07		Sleep-wake disorder	Click to Show/Hide
Dextroamphetamine	API Info	Narcolepsy [ICD-11: 7A20]		[23]
Temazepam	API Info	Insomnia [ICD-11: 7A00]		[24]
Zaleplon	API Info	Insomnia [ICD-11: 7A00]		[25]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Morphine	API Info	Anaesthesia [ICD-11: 8E22]		[26]
Gabapentin	API Info	Focal seizure [ICD-11: 8A68]		[27]
Valproic acid	API Info	Epilepsy [ICD-11: 8A60]		[28]
Ropinirole	API Info	Parkinsonism [ICD-11: 8A00]		[29]
Levetiracetam	API Info	Focal seizure [ICD-11: 8A68]		[30]
Oxcarbazepine	API Info	Epilepsy [ICD-11: 8A60]		[31]
Zonisamide	API Info	Epilepsy [ICD-11: 8A60]		[32]
Primidone	API Info	Epilepsy [ICD-11: 8A60]		[33]
Methadone	API Info	Anaesthesia [ICD-11: 8E22]		[34]
Droxidopa	API Info	Neurogenic orthostatic hypotension [ICD-11: 8D87]		[35]
ICD Disease Classification 09		Visual system disease	Click to Show/Hide
Dextromethorphan	API Info	Allergic conjunctivitis [ICD-11: 9A60]		[36]
ICD Disease Classification 10		Ear/mastoid process disease	Click to Show/Hide
Cephalexin	API Info	Acute otitis media [ICD-11: AB00]		[37]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Lisinopril	API Info	Essential hypertension [ICD-11: BA00]		[38]
Aspirin	API Info	Myocardial infarction [ICD-11: BA41]		[39]
Warfarin	API Info	Atrial fibrillation [ICD-11: BC81]		[40]
Ramipril	API Info	Essential hypertension [ICD-11: BA00]		[41]
Nifedipine	API Info	Angina pectoris [ICD-11: BA40]		[42]
Propafenone	API Info	Ventricular tachyarrhythmia [ICD-11: BC71]		[43]
Carvedilol	API Info	Congestive heart failure [ICD-11: BD10]		[44]
Digoxin	API Info	Cardiac arrhythmia [ICD-11: BC65]		[45]
Nisoldipine	API Info	Essential hypertension [ICD-11: BA00]		[46]
Furosemide	API Info	Congestive heart failure [ICD-11: BD10]		[47]
Eplerenone	API Info	Ventricular dysfunction [ICD-11: BD13]		[48]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Clarithromycin	API Info	Pneumocystis pneumonia [ICD-11: CA40]		[49]
Chlorpheniramine	API Info	Allergic rhinitis [ICD-11: CA08]		[50]
Promethazine	API Info	Allergic rhinitis [ICD-11: CA08]		[51]
Levofloxacin	API Info	Bronchitis [ICD-11: CA20]		[52]
Cefpodoxime	API Info	Bronchitis [ICD-11: CA20]		[53]
Sirolimus	API Info	Lymphangioleiomyomatosis [ICD-11: CB07]		[54]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Doxycycline	API Info	Periodontal disease [ICD-11: DA0C]		[55]
Meclizine	API Info	Functional nausea/vomiting [ICD-11: DD90]		[56]
Simethicone	API Info	Irritable bowel syndrome [ICD-11: DD91]		[57]
Mepenzolate	API Info	Peptic ulcer [ICD-11: DA61]		[58]
ICD Disease Classification 14		Skin disease	Click to Show/Hide
Clindamycin	API Info	Acne vulgaris [ICD-11: ED80]		[59]
Isotretinoin	API Info	Acne vulgaris [ICD-11: ED80]		[60]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Indomethacin	API Info	Rheumatoid arthritis [ICD-11: FA20]		[61]
Celecoxib	API Info	Rheumatoid arthritis [ICD-11: FA20]		[62]
Dexamethasone	API Info	Rheumatoid arthritis [ICD-11: FA20]		[63]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Ibuprofen	API Info	Dysmenorrhea [ICD-11: GA34]		[64]
Bethanechol	API Info	Urinary retention [ICD-11: GC01]		[65]
Methenamine	API Info	Urinary tract infection [ICD-11: GC08]		[66]
ICD Disease Classification 20		Developmental anomaly	Click to Show/Hide
Estradiol	API Info	Turner syndrome [ICD-11: LD50]		[67]
Calcitriol	API Info	Congenital alopecia [ICD-11: LC30]		[68]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
G-protein coupled receptor (GPCR)
DBT Name: Opioid receptor mu (OPRM1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 16 uM (tested by experiment)		[69]
Tested Species	Homo sapiens (Human)
UniProt ID	OPRM_HUMAN
DBT Name: Dopamine D1 receptor (DRD1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 23 uM (tested by experiment)		[69]
Tested Species	Homo sapiens (Human)
UniProt ID	DRD1_HUMAN
Hydrolase (HDase)
DBT Name: Tyrosyl-DNA phosphodiesterase 2 (TDP2)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 3500 nM (estimated based on the structural similarity with CHEMBL3813826 )		[70]
Structural Similarity	Tanimoto coefficient = 0.777777778
Tested Species	Homo sapiens (Human)
UniProt ID	TYDP2_HUMAN
Transmembrane channel/porin (TC/P)
DBT Name: GABA(A) receptor alpha-1 (GABRA1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 13 uM (tested by experiment)		[69]
Tested Species	Homo sapiens (Human)
UniProt ID	GBRA1_HUMAN

References
1	FDA label for approved minocycline from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved metronidazole from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved primaquine from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved paromomycin from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved temozolomide from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved letrozole from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved niraparib from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved levothroid from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved phentermine from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved rosuvastatin from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved phendimetrazine from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved ergocalciferol from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved risperidone from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved bupropion from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved alprazolam from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved venlafaxine from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved amitriptyline from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved hydroxyzine from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved paroxetine from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved quetiapine from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved imipramine from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved milnacipran from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved dextroamphetamine from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved temazepam from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved zaleplon from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved morphine from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved gabapentin from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved valproic acid from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved ropinirole from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved levetiracetam from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved oxcarbazepine from the official website of the U.S. Food and Drug Administration.
32	FDA label for approved zonisamide from the official website of the U.S. Food and Drug Administration.
33	FDA label for approved primidone from the official website of the U.S. Food and Drug Administration.
34	FDA label for approved methadone from the official website of the U.S. Food and Drug Administration.
35	FDA label for approved droxidopa from the official website of the U.S. Food and Drug Administration.
36	FDA label for approved dextromethorphan from the official website of the U.S. Food and Drug Administration.
37	FDA label for approved cephalexin from the official website of the U.S. Food and Drug Administration.
38	FDA label for approved lisinopril from the official website of the U.S. Food and Drug Administration.
39	FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
40	FDA label for approved warfarin from the official website of the U.S. Food and Drug Administration.
41	FDA label for approved ramipril from the official website of the U.S. Food and Drug Administration.
42	FDA label for approved nifedipine from the official website of the U.S. Food and Drug Administration.
43	FDA label for approved flecainide from the official website of the U.S. Food and Drug Administration.
44	FDA label for approved carvedilol from the official website of the U.S. Food and Drug Administration.
45	FDA label for approved digoxin from the official website of the U.S. Food and Drug Administration.
46	FDA label for approved nisoldipine from the official website of the U.S. Food and Drug Administration.
47	FDA label for approved furosemide from the official website of the U.S. Food and Drug Administration.
48	FDA label for approved eplerenone from the official website of the U.S. Food and Drug Administration.
49	FDA label for approved clarithromycin from the official website of the U.S. Food and Drug Administration.
50	FDA label for approved chlorpheniramine from the official website of the U.S. Food and Drug Administration.
51	FDA label for approved promethazine from the official website of the U.S. Food and Drug Administration.
52	FDA label for approved levofloxacin from the official website of the U.S. Food and Drug Administration.
53	FDA label for approved cefpodoxime from the official website of the U.S. Food and Drug Administration.
54	FDA label for approved sirolimus from the official website of the U.S. Food and Drug Administration.
55	FDA label for approved doxycycline from the official website of the U.S. Food and Drug Administration.
56	FDA label for approved meclizine from the official website of the U.S. Food and Drug Administration.
57	FDA label for approved simethicone from the official website of the U.S. Food and Drug Administration.
58	FDA label for approved dimenhydrinate from the official website of the U.S. Food and Drug Administration.
59	FDA label for approved clindamycin from the official website of the U.S. Food and Drug Administration.
60	FDA label for approved isotretinoin from the official website of the U.S. Food and Drug Administration.
61	FDA label for approved indomethacin from the official website of the U.S. Food and Drug Administration.
62	FDA label for approved celecoxib from the official website of the U.S. Food and Drug Administration.
63	FDA label for approved dexamethasone from the official website of the U.S. Food and Drug Administration.
64	FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
65	FDA label for approved bethanechol from the official website of the U.S. Food and Drug Administration.
66	FDA label for approved methenamine from the official website of the U.S. Food and Drug Administration.
67	FDA label for approved estradiol from the official website of the U.S. Food and Drug Administration.
68	FDA label for approved calcitriol from the official website of the U.S. Food and Drug Administration.
69	The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
70	Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft. Bioorg Med Chem Lett. 2016 Jul 15; 26(14):3232-3236.

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