Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00979)
Name	Dacarbazine
Synonyms	Click to Show/Hide the Synonyms of This API dacarbazine; DTIC; Deticene; 4342-03-4; Biocarbazine; DTIC-Dome; Biocarbazine R; ICDMT; NSC-45388; ICDT; 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide; 5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide; Di-me-triazenoimidazolecarboxamide; 5-(Dimethyltriazeno)imidazole-4-carboxamide; NSC45388; (Dimethyltriazeno)imidazolecarboxamide; NSC 45388; DTIE; 4-(3,3-Dimethyl-1-triazeno)imidazole-5-carboxamide; 4-(Dimethyltriazeno)imidazole-5-carboxamide; NCI-C04717; Dacarbazinum [INN-Latin]; Dacarbazino [INN-Spanish]; 4-(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide; MFCD00057167; Dtic-Dome (TN); UNII-7GR28W0FJI; 7GR28W0FJI; 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide; Dacarbazinum; Decarbazine; 4-[(1E)-3,3-Dimethyltriaz-1-en-1-yl]-1H-imidazole-5-carboxamide; Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazeno)-; HSDB 3219; Dacarbazino; SR-05000001598; CCRIS 190; Dacarbazine (JAN/USP/INN); 5-(Dimethyltriazeno)imidazole-4-carboximide; Dimethyltriazenoimidazolecarboxamide; NCGC00091861-01; EINECS 224-396-1; 4(5)-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide; 4(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide; AI3-52825; 4-(or 5)-(3,3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide; Dacarbazine (DTIC-Dome); CHEMBL476; SCHEMBL5560; SCHEMBL5561; SPECTRUM1500218; SCHEMBL1014331; Carboxamide, 5-(3,3-dimethyl-1-triazeno)imidazole-4-; CHEBI:94587; HMS501A08; Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-; BDBM233149; HMS2090A20; HMS2091I20; NCI C04717; Pharmakon1600-01500218; 750512-03-9; HY-B0078; CCG-35381; CCG-36068; CCG-40272; NSC759610; NSC799994; s1221; WLN: T5M CNJ DVZ ENUNN1&1; AKOS005220502; AKOS015850745; AKOS026750028; CS-1772; DB00851; KS-5186; NSC-759610; NSC-799994; Dacarbazine [USAN:USP:INN:BAN:JAN]; Dacarbazine, antineoplastic purine analog; NCGC00091861-02; NCGC00091861-03; NCGC00091861-04; NCGC00091861-05; NCGC00188955-01; H539; SBI-0051328.P003; ST51014976; C06936; Carboxamide,3-dimethyl-1-triazeno)imidazole-4-; D00288; J10199; M-2571; Imidazole-4-carboxamide,3-dimethyl-1-triazeno)-; 342D034; 5-[(dimethylamino)diazenyl]imidazole-4-carboxamide; A826278; SR-05000001598-1; SR-05000001598-3; W-106228; 1H-Imidazole-4-carboxamide,3-dimethyl-1-triazenyl)-; 4-[(E)-dimethylaminoazo]-1H-imidazole-5-carboxamide; BRD-K35520305-001-04-5; BRD-K35520305-001-07-8; (5E)-5-(dimethylaminohydrazono)imidazole-4-carboxamide; (5Z)-5-(dimethylaminohydrazono)imidazole-4-carboxamide; 5-(dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide; Imidazole-4(or 5)-carboxamide,3-dimethyl-1-triazeno)-; 5-[(E)-dimethylaminodiazenyl]-1H-imidazole-4-carboxamide; Dacarbazine, British Pharmacopoeia (BP) Reference Standard; Dacarbazine, European Pharmacopoeia (EP) Reference Standard; (5E)-5-(dimethylaminohydrazinylidene)-4-imidazolecarboxamide; 4-(or 5)-(3,3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide; Dacarbazine, United States Pharmacopeia (USP) Reference Standard; Dacarbazine, Pharmaceutical Secondary Standard; Certified Reference Material
Clinical Status	Approved
PubChem CID	135398738
Formula	C6H10N6O
Canonical SMILES	CN(C)/N=N/C1=C(NC=N1)C(=O)N
InChI	1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
InChIKey	FDKXTQMXEQVLRF-ZHACJKMWSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=135398738"></iframe>
Structure	3D MOL		2D MOL
Physicochemical Properties	Molecular Weight	182.18	Topological Polar Surface Area	99.7
	XlogP	-0.6	Complexity	215
	Heavy Atom Count	13	Rotatable Bond Count	3
	Hydrogen Bond Donor Count	2	Hydrogen Bond Acceptor Count	5

Full List of Drug Formulations (DFMs) Containing This API
Dacarbazine 200mg/vial injectable			Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Mannitol; Anhydrous Citric Acid
Dosage Form	Injectable
Company	Hikma Pharmaceuticals Usa
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Kyselina citronova	DIG Info	Perilipin-1 (IC50 = 3708 nM)	[1]
	Mannitol	DIG Info	Glycine receptor alpha-1 (EC50 = 12589.25 nM)	[2]

References
1	PubChem BioAssay data set.
2	Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.

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