Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01251)
Name
Migalastat
Synonyms    Click to Show/Hide the Synonyms of This API
Migalastat; 1-deoxygalactonojirimycin; (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol; 1-Deoxygalactostatin; 108147-54-2; UNII-C4XNY919FW; D-Galactitol, 1,5-dideoxy-1,5-imino-; C4XNY919FW; DEOXYGALACTONOJIRIMYCIN; CHEMBL110458; 108147-54-2 (free base); Amigal; galafold; DDIG; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3S,4R,5S)-; 1,5-Dideoxy-1,5-iminogalactitol; Migalastat [USAN:INN]; GR181413A; 1,5-Dideoxy-1,5-imino-D-galactitol; D-Galactitol, 1,5-dideoxy-1,5-imino; NSC658776; Tocris-1258; Migalastat (USAN/INN); D-galacto-1-Deoxynojirimycin; 2-(Hydroxymethyl)-3,4,5-piperidinetriol hydrochloride; SCHEMBL1479364; GTPL10200; CHEBI:135923; ZINC1636704; BDBM50163440; 1,5-didesoxy-l,5-imino-D-galactitol; DB05018; GR-181413A; NCGC00025085-01; DGJ; D10359; Q161613; (2R,3S,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol
Clinical Status
Approved
PubChem CID
176077
Formula
C6H13NO4
Canonical SMILES
C1[C@@H]([C@H]([C@H]([C@H](N1)CO)O)O)O
InChI
1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5+,6-/m1/s1
InChIKey
LXBIFEVIBLOUGU-DPYQTVNSSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=176077"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 163.17 Topological Polar Surface Area 93
XlogP -2.3 Complexity 132
Heavy Atom Count 11 Rotatable Bond Count 1
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Migalastat 123 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium Stearate; Pregelatinized Starch; Gelatin; Indigotine - Fd&C Blue 2; Titanium Dioxide; Black Iron Oxide; Potassium Hydroxide; Shellac
                   Dosage Form Capsule
                   Company Amicus Therapeutics Us
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [1]
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Pregelatinized starch DIG Info Multidrug resistance protein 1 (Protein expression downregulation) [3]
References
1 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
2 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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