Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01350)
Name
Polidocanol
Synonyms    Click to Show/Hide the Synonyms of This API
Polidocanol; 3055-99-0; Nonaethylene glycol monododecyl ether; 3,6,9,12,15,18,21,24,27-Nonaoxanonatriacontan-1-ol; genapol X-080; laureth-9; Polyoxyethylene (9) lauryl ether; 9043-30-5; C12E9; nonaethylene glycol monolauryl ether; Polyoxyl 9 lauryl ether; Nonaoxyethylene monododecyl ether; CHEBI:46859; MFCD00043375; NCGC00166290-02; DODECYL NONA ETHYLENE GLYCOL ETHER; DSSTox_CID_19721; DSSTox_RID_79436; DSSTox_GSID_39721; Asclera; Dodecylnonaglycol; CAS-3055-99-0; Polydocanol; Aethoxy-sklerol; Polidocanol [INN:DCF:JAN]; Dodecyl nonaethylene glycol ether; EINECS 221-284-4; Genapol X080; POELE; VARITHENA; PEG-9 lauryl ether; Macrogol 9 lauryl ether; POLYDOCANOL; THESIT; Polyoxyethylen-9-laurylether; AEO-9; SCHEMBL25580; Polyoxyethylene 9 lauryl ether; CHEMBL1231723; DTXSID5039721; Polyethylene glycol monoalkyl ether; AMY22525; Oligoethylene glycol monoalkyl ether; ZINC8214662; Tox21_112394; C12-E9; MFCD00163738; Polyethylene glycol 450 lauryl ether; AKOS028108701; Dodecylnonaoxyethylene glycol monoether; Tox21_112394_1; DB06811; NCGC00166290-01; NCGC00166290-03; HY-108294; CS-0028163; C13493; SR-01000944476; J-018016; Poly(oxy-1,2-ethanediyl),a-isotridecyl-w-hydroxy-; SR-01000944476-1; Nonaethylene glycol monododecyl ether, nonionic surfactant; Polyethylene glycol monododecyl ether (average polymer, n = 9); Polyethylene glycol monododecyl ether (average polymer, n = 9; nonaethylene glycol monododecyl ether)
Clinical Status
Approved
PubChem CID
656641
Formula
C30H62O10
Canonical SMILES
CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChI
1S/C30H62O10/c1-2-3-4-5-6-7-8-9-10-11-13-32-15-17-34-19-21-36-23-25-38-27-29-40-30-28-39-26-24-37-22-20-35-18-16-33-14-12-31/h31H,2-30H2,1H3
InChIKey
ONJQDTZCDSESIW-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=656641"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 582.8 Topological Polar Surface Area 103
XlogP 3.9 Complexity 431
Heavy Atom Count 40 Rotatable Bond Count 37
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 10
Full List of Drug Formulations (DFMs) Containing This API
          Polidocanol 180mg/18ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Ethanol; Disodium Hydrogen Phosphate Dihydrate; Potassium Dihydrogen Phosphate; Sodium Hydroxide; Hydrochloric Acid
                   Dosage Form Solution
                   Company Provensis
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Potassium phosphate monobasic DIG Info Intestinal alkaline phosphatase (IC50 = 2410 nM) [1]
Hydrochloric acid DIG Info Carbonic anhydrase V (Ki = 156 nM) [2]
          Polidocanol 77.5mg/7.75ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Ethanol; Disodium Hydrogen Phosphate Dihydrate; Potassium Dihydrogen Phosphate; Sodium Hydroxide; Hydrochloric Acid
                   Dosage Form Solution
                   Company Provensis
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Potassium phosphate monobasic DIG Info Intestinal alkaline phosphatase (IC50 = 2410 nM) [1]
Hydrochloric acid DIG Info Carbonic anhydrase V (Ki = 156 nM) [2]
          Polidocanol 10mg/2ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Water For Injection; Ethanol; Disodium Hydrogen Phosphate Dihydrate; Potassium Dihydrogen Phosphate
                   Dosage Form Solution
                   Company Chemisch Fbrk Krsslr
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Potassium phosphate monobasic DIG Info Intestinal alkaline phosphatase (IC50 = 2410 nM) [1]
          Polidocanol 20mg/2ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Water For Injection; Ethanol; Disodium Hydrogen Phosphate Dihydrate; Potassium Dihydrogen Phosphate
                   Dosage Form Solution
                   Company Chemisch Fbrk Krsslr
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Potassium phosphate monobasic DIG Info Intestinal alkaline phosphatase (IC50 = 2410 nM) [1]
References
1 Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines. Eur J Med Chem. 2014 May 6; 78:167-77.
2 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5435-9.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.