Details of the Drug Formulation (DFM)

General Information of DFM (ID: F24222)
Name
Polidocanol 180mg/18ml solution
Company
Provensis
Active Pharmaceutical Ingredient (API) Polidocanol API Info click to show the detail info of this API
Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0SF4Y DIG Info Ethanol Antimicrobial preservative ...
E0H0KW DIG Info Hydrochloric acid Acidulant
E0V4HH DIG Info Potassium phosphate monobasic Buffering agent
E0L2PN DIG Info Sodium hydroxide Alkalizing agent
E0L8YB DIG Info Sodium phosphate dibasic dihydrate Buffering agent ...
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Hydrolase (HDase)
            DBT Name: Intestinal alkaline phosphatase (IAP) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Potassium phosphate monobasic
                    Biological Activity IC50 = 2410 nM (tested by experiment) [1]
                    Tested Species Bos taurus (Bovine)
                    UniProt ID PPBI_BOVIN
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: Carbonic anhydrase IV (CA4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Hydrochloric acid
                    Biological Activity Ki = 90000 nM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH4_HUMAN
            DBT Name: Carbonic anhydrase V (CA5) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Hydrochloric acid
                    Biological Activity Ki = 156 nM (tested by experiment) [3]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH5A_HUMAN ; CAH5B_HUMAN
References
1 Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines. Eur J Med Chem. 2014 May 6; 78:167-77.
2 Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. Bioorg Med Chem Lett. 2004 Dec 6; 14(23):5769-73.
3 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5435-9.

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